CERVICAL INTRAEPITHELIAL NEOPLASIA IN HIV-INFECTED WOMEN IN A SOUTHEASTERN US POPULATION

The objectives of our study were to determine the prevalence of cervic al intraepithelial neoplasia (CIN) in a southeastern human immunodefic iency virus (HIV)-positive population relative to an HIV-negative cont rol group and to compare these findings with published reports from ot her geographic regions. Demographic, medical, and cytopathologic data were collected on 89 HIV-positive women receiving care at the Duke Adu lt Infectious Disease Clinic. Comparisons were made with 100 HIV-negat ive obstetric patients who delivered at Duke and with published report s from other regions of the United States and abroad. Cervical intraep ithelial neoplasia was present in 43 (49%) of 87 HIV-positive women co mpared with 23% of the 100 HIV-negative patients. Two of the HIV-posit ive patients had invasive cancer. Comparison of these patients with pa tients from other geographic regions revealed similar odds ratios for the presence of CIN in HIV-positive patients compared with HIV-negtive patients. These results suggest a significantly increased risk for ce rvical dysplasia in HIV-positive women in this southeastern population .