Prostate cancer metastatic to the penis is rare. We describe a patient
who had a painful nodule in the corpora cavernosa during adjuvant rad
iotherapy after radical prostatectomy for prostate cancer. Biopsy of t
he nodule revealed a poorly differentiated adenocarcinoma. Immunohisto
chemical staining for prostate-specific antigen confirmed a prostatic
origin for the neoplasm. The lesion to the penis was treated with radi
ation therapy in conjunction with androgen deprivation therapy, The pe
nile pain completely resolved, and the patient remains alive, 30 month
s after initiation of therapy.