2 RP-HPLC SENSITIVE METHODS TO QUANTIFY AND IDENTIFY BISPHENOL A DIGLYCIDYL ETHER AND ITS HYDROLYSIS PRODUCTS .1. EUROPEAN-UNION AQUEOUS FOOD SIMULANTS
Pp. Losada et al., 2 RP-HPLC SENSITIVE METHODS TO QUANTIFY AND IDENTIFY BISPHENOL A DIGLYCIDYL ETHER AND ITS HYDROLYSIS PRODUCTS .1. EUROPEAN-UNION AQUEOUS FOOD SIMULANTS, Journal of agricultural and food chemistry, 45(9), 1997, pp. 3493-3500
Two RP-HPLC with fluorescence detection alternative methods have been
proposed to quantify and identify bisphenol A diglycidyl ether (BADGE)
, a monomer of epoxy resins used as a coating for food packaging mater
ials, and its hydrolysis products (HPs) in three aqueous food liquid s
imulants: 15% (v/v) ethanol, 3% (w/v) acetic acid, and distilled water
. Both isocratic and gradient chromatographic methods were developed t
o determine this monomer at the specific migration limit (SML) level (
restriction proposed by European Union legislation) and also the two H
Ps in aqueous EEC food simulants. All calibration lines had correlatio
n coefficients greater than 0.997 and detection limits of less than 2
mu g of BADGE/L. Standard deviations (in percent) obtained in the prec
ision calculation were less than 3% for BADGE. Furthermore, both metho
ds were applied to analyze these compounds in three types of epoxy can
coatings that contact food.