The ever increasing rate of inflation and the reality that resources f
or medical care are limited has led to significant changes in the reim
bursement for health care services. These influences have convinced he
alth care policy makers to closely evaluate innovative health services
in terms of the benefits and costs. New pharmaceutical services must
be economically justified in order to exist in the future. This is cru
cial to the expansion and adoption of pharmaceutical services. Applica
tion of economic evaluations is not new to the health care sector. Unt
il recently, there were no incentive to transfer this interest into wi
despread use. As health care expenditures have escalated over the past
two decades, the number of applications of these techniques has incre
ased. Especially significant are cost-benefit and cost-effectiveness e
valuations of medical practice, pharmaceuticals, and other health care
technologies. Pharmacoeconomic analysis is an important tool to assis
t in the evaluation of new pharmaceutical services and technologies. E
ssentially, economic analytical methods are used to weigh the positive
and negative consequences of alternative courses of action. The usefu
lness of pharmacoeconomic analyses is in resource allocation, with the
purpose of achieving the highest return on investment or accomplishin
g a given objective in the least costly manner. Unfortunately, very fe
w pharmacy programs have been evaluated using pharmacoeconomic techniq
ues. The purpose of this article is to present various methods to asse
ss the economic value of therapeutic drug monitoring services in socie
ty and for specific patient populations. Additionally, this article wi
ll review the previous attempts and various issues surrounding the eco
nomic justification of therapeutic drug monitoring.