EXPRESSION OF LUNG RESISTANCE-RELATED PROTEIN (LRP) IN INITIAL AND RELAPSED CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA

Authors
VOLM M STAMMLER G ZINTL F KOOMAGI R SAUERBREY A
Citation
M. Volm et al., EXPRESSION OF LUNG RESISTANCE-RELATED PROTEIN (LRP) IN INITIAL AND RELAPSED CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA, Anti-cancer drugs, 8(7), 1997, pp. 662-665
Citations number
17
Categorie Soggetti
Oncology,"Pharmacology & Pharmacy
Journal title
Anti-cancer drugs → ACNP
ISSN journal
09594973
Volume
8
Issue
7
Year of publication
1997
Pages
662 - 665
Database
ISI
SICI code
0959-4973(1997)8:7<662:EOLRP(>2.0.ZU;2-N
Abstract
Thirty-eight children with initial and 25 children with relapsed lymph oblastic leukemia (ALL) were analyzed for the expression of LRP (lung resistance protein or p110 major vault protein) using immunocytochemis try. LRP expression was found in 18 oi 38 (47%) children with initial ALL and in 17 of 25 (68%) children with relapsed ALL. Children with in itial ALL and without LRP expression had significantly longer relapse- free intervals than patients with LRP expression.