SELECTIVE DRUG-DELIVERY TO PERI-TUMORAL REGION AND REGIONAL LYMPHATICS BY LOCAL INJECTION OF ACLARUBICIN ADSORBED ON ACTIVATED CARBON PARTICLES IN PATIENTS WITH BREAST-CANCER - A PILOT-STUDY

Authors
HAGIWARA A TAKAHASHI T SAWAI K SAKAKURA C SHIRASU M OHGAKI M IMANISHI T YAMASAKI J TAKEMOTO Y KAGEYAMA N
Citation
A. Hagiwara et al., SELECTIVE DRUG-DELIVERY TO PERI-TUMORAL REGION AND REGIONAL LYMPHATICS BY LOCAL INJECTION OF ACLARUBICIN ADSORBED ON ACTIVATED CARBON PARTICLES IN PATIENTS WITH BREAST-CANCER - A PILOT-STUDY, Anti-cancer drugs, 8(7), 1997, pp. 666-670
Citations number
18
Categorie Soggetti
Oncology,"Pharmacology & Pharmacy
Journal title
Anti-cancer drugs → ACNP
ISSN journal
09594973
Volume
8
Issue
7
Year of publication
1997
Pages
666 - 670
Database
ISI
SICI code
0959-4973(1997)8:7<666:SDTPRA>2.0.ZU;2-1
Abstract
ACR-CH, which consists of aclarubicin (ACR) adsorbed onto activated ca rbon particles, was developed for locoregional chemotherapy for breast cancer. Thirty patients with breast cancer received an ACR (10 mg) in jection intra- and peritumorally, either as ACR-CH or as ACR aqueous s olution (ACR-AQ) 5 min before the operation for breast cancer. The ACR concentrations were significantly higher in the peritumoral regions a nd regional lymph nodes, and were also significantly lower in the bloo d plasma in patients given ACR-CH versus patients given ACR-AQ.