W. Noske et al., ENDOTHELIN-LIKE IMMUNOREACTIVITY IN AQUEOUS-HUMOR OF PATIENTS WITH PRIMARY OPEN-ANGLE GLAUCOMA AND CATARACT, Graefe's archive for clinical and experimental ophthalmology, 235(9), 1997, pp. 551-552
Background: Experimental evidence suggests a role of endothelin-l (ET)
in the regulation of intraocular pressure (IOP). Method: Therefore, i
n patients undergoing cataract surgery, ET-like immunoreactivity (ETIR
) was measured by radioimmunoassay in pooled samples of aqueous humor
of eyes with primary open-angle glaucoma (POAG) and normotensive eyes
with cataract only. Results: ETIR was significantly (P < 0.05) higher
in patients with cataract and POAG (20.5 +/- 1.8 pg/ml, n = 12; preope
rative IOP 21.4 +/- 1.1 mmHg, n = 33) than in patients with cataract o
nly (15.8 +/- 1.6 pg/ml, n = 15; preoperative IOP 16.0 +/- 0.6 mmHg, n
= 77). Conclusion: This finding may indicate a role of ET in POAG or
ocular antihypertensive treatment, and its relevance should be further
investigated.