RECOVERY FROM NEUROENDOCRINOLOGICAL ABNORMALITIES AND FRONTAL HYPOPERFUSION AFTER REMISSION IN A CASE WITH RAPID-CYCLING BIPOLAR DISORDER

Citation
E. Shimizu et al., RECOVERY FROM NEUROENDOCRINOLOGICAL ABNORMALITIES AND FRONTAL HYPOPERFUSION AFTER REMISSION IN A CASE WITH RAPID-CYCLING BIPOLAR DISORDER, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 51(4), 1997, pp. 207-212
Citations number
33
Categorie Soggetti
Clinical Neurology",Neurosciences,Psychiatry
ISSN journal
13231316
Volume
51
Issue
4
Year of publication
1997
Pages
207 - 212
Database
ISI
SICI code
1323-1316(1997)51:4<207:RFNAAF>2.0.ZU;2-L
Abstract
A 51-year-old Japanese woman who had been suffering from a rapid cycli ng affective disorder (RCAD) for 24 years responded to combined clonaz epam and carbamazepine therapy. Before remission, she showed neuroendo crinological and neuroimaging abnormalities such as subclinical hypoth yroidism with exaggerated response to thyrotropin releasing hormone (T RH) inject-on, non-suppression on the dexamethasone suppression test ( DST) and hypofrontality ill cerebral blood now. Her symptoms improved remarkably soon after adjunctive clonazepam treatment. After remission , her biological markers gradually returned to normal. First, subclini cal hypothyroidism improved 2 months after remission. Next, hypofronta lity disappeared 18 months later. Furthermore, non-suppression on the DST normalized 34 months later. The normalization of biological marker s with apparent recovery from RCAD suggests a decreased risk of relaps e into mood disorder. These findings reiterate the importance of follo wing-up on the biological markers in RCAD for years after remission.