K. Wada et al., PROGNOSIS AND CLINICAL-FEATURES OF INTRACTABLE EPILEPSY - A PROSPECTIVE-STUDY, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 51(4), 1997, pp. 233-235
Of the epileptic patients who were treated for greater than or equal t
o 5 years until the end of 1990 and had more than four seizures in 199
0, 63 patients had been treated without interruption until the end of
1995. We analyzed their clinical courses from 1990 to 1995 prospective
ly. More than half the subjects were diagnosed with temporal lobe epil
epsy. Twenty cases had presumed etiology, and 32 had neuropsychiatric
complications. Of the subjects whose seizures were not controlled with
conventional antiepileptic drugs (AED), 11 cases demonstrated signifi
cant improvement when new AED; that is, lamotrigine, vigabatrin, cloba
zam, topiramate, tiagabine or CGP33101 were added. However, 10 patient
s did not respond to new AED. Presumed etiology, neuropsychiatric comp
lications, multiple epileptic foci in EEG and abnormalities on head CT
or MRI were characteristics of the patients whose seizures were resis
tant to new AED.