MIZORIBINE IN STEROID-DEPENDENT NEPHROTIC SYNDROME OF CHILDHOOD

We evaluated a 1-year course of a newly developed immunosuppressant, m izoribine (at a dosage of 3 mg/kg body weight per day), in nine childr en with steroid-dependent nephrotic syndrome. Steroid treatment could be discontinued in two patients and the maintenance dosage of steroid could be reduced to less than half of that given before mizoribine the rapy in a third. There were no beneficial effects in the remaining six patients. No adverse effects of mizoribine were observed during the c ourse of therapy.