AORTIC AND RENAL-ARTERY THROMBOSIS IN A NEONATE - RECOVERY WITH THROMBOLYTIC THERAPY

This report describes a neonate with acute renal failure associated wi th extensive aortic and bilateral renal artery thrombosis attributed t o inadequate breastfeeding and severe dehydration. Dialytic and genera l supportive care, together with concurrent anticoagulation, and conti nuous aggressive intrathrombic instillation of urokinase for 5 days re sulted in near-complete thrombolysis. Renal functional recovery began 11 days after the onset of anuria. Despite ischemic atrophy of the lef t kidney, renal function and blood pressure were normal on follow-up. Thus, in neonates thrombolytic therapy may positively impact survival and recovery of renal function even in the setting of prolonged ischem ic renal injury.