POLYSACCHARIDE VACCINES - DETERMINANTS OF CLINICAL EFFICACY

Authors
MUSHER DM
Citation
Dm. Musher, POLYSACCHARIDE VACCINES - DETERMINANTS OF CLINICAL EFFICACY, Hospital practice, 32(9), 1997, pp. 37
Citations number
8
Categorie Soggetti
Medicine, General & Internal
Journal title
Hospital practice → ACNP
ISSN journal
87502836
Volume
32
Issue
9
Year of publication
1997
Database
ISI
SICI code
8750-2836(1997)32:9<37:PV-DOC>2.0.ZU;2-Q
Abstract
Many common bacteria cause disease because their polysaccharide capsul es prevent phagocytosis. Antibody directed against these capsules is t he basis for some of the most effective bacterial vaccines. Neverthele ss, many diseases caused by such bacteria continue to cause serious mo rbidity. Recent findings indicate that several previously unrecognized factors (most notably, genetics) determine responsiveness to capsular polysaccharides.