K. Kashihara et al., NONINSULIN-DEPENDENT DIABETES MELLITUS-RELATED ENCEPHALOPATHY PRESENTING WITH AMNESIA, PERSONALITY-CHANGE, AND AUTONOMIC SEIZURE, Internal medicine, 36(9), 1997, pp. 633-636
We describe a patient with noninsulin-dependent diabetes mellitus pres
enting with an amnestic disorder, personality change, and autonomic se
izure. Magnetic resonance images of the brain showed T2-high signal le
sion in the hippocampi bilaterally and nonspecific white matter diseas
e, while single photon emission computed tomography revealed a diffuse
reduction of cerebral blood flow. Sensory and auditory evoked potenti
als revealed delayed impulse conduction velocities in the central nerv
ous system. Degenerative changes caused by a microvascular angiopathy
related to noninsulin-dependent diabetes mellitus may underlie the cen
tral nervous system manifestations in our patient.