NONINSULIN-DEPENDENT DIABETES MELLITUS-RELATED ENCEPHALOPATHY PRESENTING WITH AMNESIA, PERSONALITY-CHANGE, AND AUTONOMIC SEIZURE

We describe a patient with noninsulin-dependent diabetes mellitus pres enting with an amnestic disorder, personality change, and autonomic se izure. Magnetic resonance images of the brain showed T2-high signal le sion in the hippocampi bilaterally and nonspecific white matter diseas e, while single photon emission computed tomography revealed a diffuse reduction of cerebral blood flow. Sensory and auditory evoked potenti als revealed delayed impulse conduction velocities in the central nerv ous system. Degenerative changes caused by a microvascular angiopathy related to noninsulin-dependent diabetes mellitus may underlie the cen tral nervous system manifestations in our patient.