CYANAMIDE-INDUCED GRANULOCYTOPENIA

We report a 64-year-old male with granulocytopenia and dermatitis due to cyanamide treatment. We administered cyanamide for alcoholism. Afte r about one month he suffered from scaly erythema over his whole body and granulocytopenia (granulocyte; 140/mu l) with maturation arrest in bone marrow. After cessation of cyanamide and the start of granulocyt e colony-stimulating factor administration, the skin eruption ameliora ted gradually, and the peripheral blood granulocyte counts increased. Cyanamide showed positive results in the drug lymphocyte stimulation t est (198%) and the patch test led to the diagnosis of granulocytopenia and dermatitis induced by cyanamide. After restarting glibenclamide a nd diazepam administration, his granulocytopenia did not reoccur. To o ur knowledge, this is the first report of a case with granulocytopenia induced by cyanamide.