Klebsiella pneumoniae is an uncommon cause of community-acquired pneum
onia except in alcoholics. Klebsiella may mimic pulmonary reactivation
tuberculosis because it presents with hemoptysis and cavitating lesio
ns. Klebsiella pneumoniae is a difficult infection to treat because of
the organism's thick capsule. Klebsiella is best treated with third-a
nd fourth-generation cephalosporins, quinolones, or carbapenems. Monot
herapy is just as effective as a combination treatment in Klebsiella p
neumoniae because newer agents are used. In the past, older agents wit
h less anti-Klebsiella activity were needed for effective treatment. T
he patient we present was initially thought to have pulmonary tubercul
osis,and when found to have Klebsiella pneumoniae, the suggested treat
ment was monotherapy with ceftriaxone. The patient was treated parente
rally initially, and then was treated for 3 weeks with oral ofloxacin.