PHOSPHODIESTERASE-4 INHIBITORS FOR THE TREATMENT OF ASTHMA

This paper reviews the literature on the modulation of cyclic adenosin e 3',5'-monophosphates (cAMP) by inhibition of phosphodiesterase 4 (PD E 4) enzyme. It highlights why PDE 4 is an interesting anti-inflammato ry target, particularly for asthma. Focus is given to the selective an d non-selective phosphodiesterase inhibitors presently disclosed in th e current scientific literature and patent literature up to June of 19 96. It reviews the pre-clinical and clinical data available for these inhibitors and discusses the future for development of novel PDE 4 inh ibitors.