EFFICACY OF CDDP AND AGM-1470 CHEMOTHERAPY AGAINST LUNG METASTASIS INRAT OSTEOSARCOMA DEPENDS ON THE TIMING OF COMBINED ADMINISTRATION

The efficacy of combination therapy with cis-diammine-dichloroplatinum (II) (CDDP) and o-(chloroacetyl-carbomoyl) fumagillol (AGM-1470) was evaluated experimentally using a transplantable rat osteosarcoma line, previously established in our laboratory, with a high potential for m etastasis. Tumor-bearing male Fischer 344 rats were administered CDDP (2.5 mg/kg) together with, or after discontinuation of, AGM-1470 treat ment (10 mg/kg/body weight/week). When CDDP was administered three day s after discontinuation of AGM-1470 the most pronounced antimetastatic effects were observed, although the antitumor effect was approximatel y the same.