COMPARATIVE-EVALUATION OF TARGETING EFFICIENCY OF CHARGED AND NEUTRALLIPOSOMES OF 5-FLUOROURACIL

Citation
D. Rajendran et al., COMPARATIVE-EVALUATION OF TARGETING EFFICIENCY OF CHARGED AND NEUTRALLIPOSOMES OF 5-FLUOROURACIL, Drug development and industrial pharmacy, 23(11), 1997, pp. 1099-1104
Citations number
8
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
ISSN journal
03639045
Volume
23
Issue
11
Year of publication
1997
Pages
1099 - 1104
Database
ISI
SICI code
0363-9045(1997)23:11<1099:COTEOC>2.0.ZU;2-3
Abstract
Liposomes were prepared from egg lecithin by the modified ether inject ion technique using stearylamine and dicetyl phosphate as the charge-i nducing agents. Comparative evaluations of charged and neutral liposom es for drug entrapment, size distribution, in vitro drug release, and in vivo drug targeting were made. The charged liposomes were larger in size and showed better drug entrapment efficiency than the neutral li posomes. However, no difference in the pattern of in vitro drug releas e was observed. Charged liposomes were found entrapped more in the org ans of the reticulo-endothelial system than the neutral liposomes.