D. Rajendran et al., COMPARATIVE-EVALUATION OF TARGETING EFFICIENCY OF CHARGED AND NEUTRALLIPOSOMES OF 5-FLUOROURACIL, Drug development and industrial pharmacy, 23(11), 1997, pp. 1099-1104
Liposomes were prepared from egg lecithin by the modified ether inject
ion technique using stearylamine and dicetyl phosphate as the charge-i
nducing agents. Comparative evaluations of charged and neutral liposom
es for drug entrapment, size distribution, in vitro drug release, and
in vivo drug targeting were made. The charged liposomes were larger in
size and showed better drug entrapment efficiency than the neutral li
posomes. However, no difference in the pattern of in vitro drug releas
e was observed. Charged liposomes were found entrapped more in the org
ans of the reticulo-endothelial system than the neutral liposomes.