PERCUTANEOUS-ABSORPTION OF LHRH THROUGH PORCINE SKIN - EFFECT OF N-METHYL 2-PYRROLIDONE AND ISOPROPYL MYRISTATE

Authors
BHATIA KS SINGH J
Citation
Ks. Bhatia et J. Singh, PERCUTANEOUS-ABSORPTION OF LHRH THROUGH PORCINE SKIN - EFFECT OF N-METHYL 2-PYRROLIDONE AND ISOPROPYL MYRISTATE, Drug development and industrial pharmacy, 23(11), 1997, pp. 1111-1114
Citations number
12
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
Drug development and industrial pharmacy → ACNP
ISSN journal
03639045
Volume
23
Issue
11
Year of publication
1997
Pages
1111 - 1114
Database
ISI
SICI code
0363-9045(1997)23:11<1111:POLTPS>2.0.ZU;2-9
Abstract
The effect of penetration enhancer (PE) on the in vitro permeability o f luteinizing hormone-releasing hormone (LHRH) through porcine epiderm is was investigated. The permeability coefficient of LHRH significantl y increased (p < 0.05) through PE-(e.g., n-methyl 2-pyrrolidone [NMP], and isopropyl myristate [IPM]) treated epidermis in comparison to the control (without PE-pretreated epidermis). The higher permeability co efficient was observed with NMP followed by IPM. This shows that PE su ch as NMP and IPM can enhance the percutaneous absorption of peptides such as LHRH.