ETODOLAC AND SOLID DISPERSION WITH BETA-CYCLODEXTRIN

Etodolac/beta-cyclodextrin (Eto/beta-CD) dispersions were prepared wit h a view to study the influence of beta-CD on the solubility and disso lution rate of this poorly soluble drug. Two systems were used: physic al mixture of Eto/beta-CD and kneading solid dispersion of Eto/beta-CD . Physical characterization of the prepared systems was carried out by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), x-ray, and IR studies. The solubility and dissolution rate of Eto were increased with beta-CD physical mixture as well as with Eto/b eta-CD kneading solid dispersion. However, enhancement was not statist ically different among various cyclodextrin dispersions.