EFFECT OF ECABET SODIUM ON HELICOBACTER-PYLORI ADHESION TO GASTRIC EPITHELIAL-CELLS

Helicobacter pylori is a major etiological agent in gastroduodenal dis orders, with the adhesion of H. pylori to gastric epithelial cells bei ng the initial step of H. pylori infection. Inhibition of H. pylori ad hesion is thus a therapeutic target in preventing H. pylori infection. We evaluated the effect of ecabet sodium, an antiulcer agent, on H. p ylori adhesion to gastric epithelial cells, using our previously estab lished enzyme-linked immunosorbent assay. The adhesion of H. pylori wa s significantly inhibited by ecabet sodium in a dose dependent manner. Our studies suggest that ecabet sodium inhibits the adhesion of H. py lori to gastric epithelial cells.