Atrial transseptal catheterization is usually performed with fluorosco
pic guidance of the needle. We report our experience with both fluoros
copic and transesophageal guidance in patients who would otherwise hav
e been at risk by using only fluoroscopy. A total of eleven procedures
were performed during a 4 year period. The relative contraindications
(some patients had several contraindications) included prior valve re
placement (5 patients), prior myocardial revascularization (4 patients
), severe dilatation of the left atrium (4 patients), severe dilatatio
n. of the ascending aorta (4 patients), and kyphoscoliosis (3 patients
). All eleven patients had the transesophageal guided transseptal cath
eterization performed without complications and without significantly
prolonging the procedure. The results of this preliminary, smalt, and
retrospective study suggest that transesophageal echocardiography may
enhance the safety of transseptal catheterization. in high risk patien
ts. Further prospective studies are needed.