INSERTIONAL INACTIVATION OF A TET(K) TET(L) LIKE TRANSPORTER DOES NOTELIMINATE TETRACYCLINE RESISTANCE IN BACILLUS-CEREUS/

Authors
OKSTAD OA GRONSTAD A LINDBACK T KOLSTO AB
Citation
Oa. Okstad et al., INSERTIONAL INACTIVATION OF A TET(K) TET(L) LIKE TRANSPORTER DOES NOTELIMINATE TETRACYCLINE RESISTANCE IN BACILLUS-CEREUS/, FEMS microbiology letters, 154(2), 1997, pp. 181-186
Citations number
24
Categorie Soggetti
Microbiology
Journal title
FEMS microbiology letters → ACNP
ISSN journal
03781097
Volume
154
Issue
2
Year of publication
1997
Pages
181 - 186
Database
ISI
SICI code
0378-1097(1997)154:2<181:IIOATT>2.0.ZU;2-1
Abstract
Bacillus cereus ATCC 10987 and ATCC 14579 can be induced to high level s of resistance to tetracycline. The chromosomal B. cereus gene bctl e ncodes a transmembrane protein with homology to Gram-positive tetracyc line efflux proteins and relation to other members of the major facili tator superfamily of transport proteins. A mutant strain containing an insertionally inactivated bctl gene did not show impaired tetracyclin e resistance. No additional altered phenotype was observed in the muta nt. Accumulation studies suggested that the resistance mechanism invol ves a reduced sensitivity to intracellular tetracycline.