RELATIONSHIP BETWEEN PATHOGENICITY OF COXIELLA-BURNETII ISOLATES AND GENE-SEQUENCES OF THE MACROPHAGE INFECTIVITY POTENTIATOR (CBMIP) AND SENSOR-LIKE PROTEIN (QRSA)

Authors
MASUZAWA T SAWAKI K NAGAOKA H AKIYAMA M HIRAI K YANAGIHARA Y
Citation
T. Masuzawa et al., RELATIONSHIP BETWEEN PATHOGENICITY OF COXIELLA-BURNETII ISOLATES AND GENE-SEQUENCES OF THE MACROPHAGE INFECTIVITY POTENTIATOR (CBMIP) AND SENSOR-LIKE PROTEIN (QRSA), FEMS microbiology letters, 154(2), 1997, pp. 201-205
Citations number
18
Categorie Soggetti
Microbiology
Journal title
FEMS microbiology letters → ACNP
ISSN journal
03781097
Volume
154
Issue
2
Year of publication
1997
Pages
201 - 205
Database
ISI
SICI code
0378-1097(1997)154:2<201:RBPOCI>2.0.ZU;2-6
Abstract
Coxiella burnetii, the Q fever agent, is an obligate intracellular bac terium and survival in phagolysosomes is an important virulence factor . The present study was performed to determine the relationship betwee n its pathogenicity and genes I-elated to its survival in macrophages, i.e. macrophage infectivity potential or and Q fever agent regulatory sensor-like protein. The sequence similarity was more than 99% among Japanese, European and American strains, and no relationship was found between pathogenicity in guinea pigs and these genes.