OKT3 THERAPY FOR TRANSFUSION-ASSOCIATED GRAFT-VERSUS-HOST DISEASE IN A NEONATE

Citation
T. Murakami et al., OKT3 THERAPY FOR TRANSFUSION-ASSOCIATED GRAFT-VERSUS-HOST DISEASE IN A NEONATE, Acta Paediatrica Japonica Overseas Edition, 39(4), 1997, pp. 462-465
Citations number
13
Categorie Soggetti
Pediatrics
ISSN journal
03745600
Volume
39
Issue
4
Year of publication
1997
Pages
462 - 465
Database
ISI
SICI code
0374-5600(1997)39:4<462:OTFTGD>2.0.ZU;2-E
Abstract
Transfusion-associated graft-versus-host disease (TA-GVHD) is a fatal side effect of blood transfusion. The present study describes a case o f TA-GVHD in a neonate treated with anti-CD3 monoclonal antibody (OKT3 ). The patient died of systemic bacterial infection. However, it is su ggested that OKT3 suppressed the graft-versus-host reaction due to the improvement in the clinical signs and a change in the human leucocyte antigen (HLA) type on the surface of circulating lymphocytes. A relat ively large dose of OKT3 together with steroid pulse therapy and cyclo sporin A may be required for the control of TA-GVHD in neonates.