HEMISYNTHESIS OF RHAZINILAM ANALOGS - STRUCTURE-ACTIVITY-RELATIONSHIPS ON TUBULIN-MICROTUBULE SYSTEM

Authors
DAVID B SEVENET T THOISON O AWANG K PAIS M WRIGHT M GUENARD D
Citation
B. David et al., HEMISYNTHESIS OF RHAZINILAM ANALOGS - STRUCTURE-ACTIVITY-RELATIONSHIPS ON TUBULIN-MICROTUBULE SYSTEM, Bioorganic & medicinal chemistry letters, 7(17), 1997, pp. 2155-2158
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
17
Year of publication
1997
Pages
2155 - 2158
Database
ISI
SICI code
0960-894X(1997)7:17<2155:HORA-S>2.0.ZU;2-D
Abstract
Semi-synthesis of derivatives of rhazinilam, an antitubulin compound, delineated some molecular features necessary for biological activity. In the course of this study, the formation of rhazinilam from 1,2-dide hydroaspidospermidine is reexamined and a new mechanism is proposed. ( C) 1997 Elsevier Science Ltd.