NOVEL HYDROXYPHOSPHONATE INHIBITORS OF CD-45 TYROSINE PHOSPHATASE

Authors
FRECHETTE RF ACKERMAN C BEERS S LOOK R MOORE J
Citation
Rf. Frechette et al., NOVEL HYDROXYPHOSPHONATE INHIBITORS OF CD-45 TYROSINE PHOSPHATASE, Bioorganic & medicinal chemistry letters, 7(17), 1997, pp. 2169-2172
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
17
Year of publication
1997
Pages
2169 - 2172
Database
ISI
SICI code
0960-894X(1997)7:17<2169:NHIOCT>2.0.ZU;2-9
Abstract
CD-45 tyrosine phosphatase [E.C. 3.1.3.48] is an important player in t he regulation of cell activation and proliferation in hematopoetic cel ls. As part of a program in immune response modulation, we prepared th e first series of small organic molecule inhibitors of CD-45. The prep aration and in vitro screening of these hydroxyphosphonates is describ ed herein. (C) 1997 Elsevier Science Ltd.