SYNTHESIS AND RECEPTOR-BINDING STUDIES OF QUINOLINIC DERIVATIVES AS MELATONIN RECEPTOR LIGANDS

Authors
LI PK CHU GH GILLEN ML WITTENDERBY PA
Citation
Pk. Li et al., SYNTHESIS AND RECEPTOR-BINDING STUDIES OF QUINOLINIC DERIVATIVES AS MELATONIN RECEPTOR LIGANDS, Bioorganic & medicinal chemistry letters, 7(17), 1997, pp. 2177-2180
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
17
Year of publication
1997
Pages
2177 - 2180
Database
ISI
SICI code
0960-894X(1997)7:17<2177:SARSOQ>2.0.ZU;2-0
Abstract
We report the development of melatonin receptor ligands containing a q uinolinic nucleus. Ligands containing a neutral moiety within the nucl eus displayed high affinity for melatonin receptors while those analog s containing a permanently charged nucleus had very low affinity for m elatonin receptors. (C) 1997 Elsevier Science Ltd.