STRUCTURE-BASED DESIGN OF NONPEPTIDIC PYRIDONE ALDEHYDES AS INHIBITORS OF INTERLEUKIN-1-BETA CONVERTING-ENZYME

Authors
GOLEC JMC MULLICAN MD MURCKO MA WILSON KP KAY DP JONES SD MURDOCH R BEMIS GW RAYBUCK SA LUONG YP LIVINGSTON DJ
Citation
Jmc. Golec et al., STRUCTURE-BASED DESIGN OF NONPEPTIDIC PYRIDONE ALDEHYDES AS INHIBITORS OF INTERLEUKIN-1-BETA CONVERTING-ENZYME, Bioorganic & medicinal chemistry letters, 7(17), 1997, pp. 2181-2186
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
17
Year of publication
1997
Pages
2181 - 2186
Database
ISI
SICI code
0960-894X(1997)7:17<2181:SDONPA>2.0.ZU;2-M
Abstract
Pyridone derivatives, especially with 6-aryl substituents, have been s hown to be useful P-2-P-3 peptidomimetic scaffolds for the design of p otent inhibitors of ICE. (C) 1997 Elsevier Science Ltd.