NOVEL INHIBITORS OF INFLUENZA SIALIDASES RELATED TO ZANAMIVIR - HETEROCYCLIC REPLACEMENTS OF THE GLYCEROL SIDE-CHAIN

Authors
SMITH PW WHITTINGTON AR SOLLIS SL HOWES PD TAYLOR NR
Citation
Pw. Smith et al., NOVEL INHIBITORS OF INFLUENZA SIALIDASES RELATED TO ZANAMIVIR - HETEROCYCLIC REPLACEMENTS OF THE GLYCEROL SIDE-CHAIN, Bioorganic & medicinal chemistry letters, 7(17), 1997, pp. 2239-2242
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
17
Year of publication
1997
Pages
2239 - 2242
Database
ISI
SICI code
0960-894X(1997)7:17<2239:NIOISR>2.0.ZU;2-G
Abstract
A series of substituted 4-amino-4H-pyran-2-carboxylic acid 6-triazoles and oxadiazoles are described. The compounds are inhibitors of influe nza virus sialidases which: in general, show a similar pattern of acti vity and selectivity to recently reported 4H-pyran-2-carboxylic acid 6 -carboxamides. (C) 1997 Elsevier Science Ltd.