SYNTHESIS OF NEW 3-THIOSUBSTITUTED CARBACEPHEM ANTIBIOTICS AND THEIR ACTIVITY AGAINST PENICILLIN-RESISTANT STREPTOCOCCUS-PNEUMONIAE

Authors
BLASZCZAK LC EID CN FLOKOWITSCH J GREGORY GS HITCHCOCK SA HUFFMAN GW MAYHUGH DR NESLER MJ PRESTON DA ZIAEBRAHIMI M
Citation
Lc. Blaszczak et al., SYNTHESIS OF NEW 3-THIOSUBSTITUTED CARBACEPHEM ANTIBIOTICS AND THEIR ACTIVITY AGAINST PENICILLIN-RESISTANT STREPTOCOCCUS-PNEUMONIAE, Bioorganic & medicinal chemistry letters, 7(17), 1997, pp. 2261-2264
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
17
Year of publication
1997
Pages
2261 - 2264
Database
ISI
SICI code
0960-894X(1997)7:17<2261:SON3CA>2.0.ZU;2-V
Abstract
The synthesis of a series of 3-thiosubstituted carbacephem derivatives is described. The compounds were assayed against penicillin susceptib le, intermediate and resistant strains of Streptococcus pneumoniae. Se veral analogs displayed potent in vitro activity against these organis ms. (C) 1997 Elsevier Science Ltd.