A CONFORMATIONAL STUDY OF LIGANDS FOR OMEGA-MODULATORY SITES OF GABA(A) RECEPTORS BY NOESY NMR-SPECTROSCOPY AND DISTANCE GEOMETRY

Authors
OLIVIER A SEVRIN M DURANT F GEORGE P
Citation
A. Olivier et al., A CONFORMATIONAL STUDY OF LIGANDS FOR OMEGA-MODULATORY SITES OF GABA(A) RECEPTORS BY NOESY NMR-SPECTROSCOPY AND DISTANCE GEOMETRY, Bioorganic & medicinal chemistry letters, 7(17), 1997, pp. 2277-2282
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
17
Year of publication
1997
Pages
2277 - 2282
Database
ISI
SICI code
0960-894X(1997)7:17<2277:ACSOLF>2.0.ZU;2-L
Abstract
Conformational analysis by NOESY NMR spectroscopy and Distance Geometr y of an omega(1), selective (zolpidem) and a non selective (saripidem) ligand of omega modulatory sites suggests that the single set of conf ormations observed with zolpidem could be account for its omega, selec tive properties. The methodology applied in this study appears to be a powerful technique to explore conformational space of non-peptidic li gands of GABA, receptor subtypes. (C) 1997 Elsevier Science Ltd.