ANTI-HISTAMINIC ACTIVITY OF BROMOPYRROLE ALKALOIDS ISOLATED FROM CARIBBEAN AGELAS SPONGES

Authors
CAFIERI F CARNUCCIO R FATTORUSSO E TAGLIALATELASCAFATI O VALLEFUOCO T
Citation
F. Cafieri et al., ANTI-HISTAMINIC ACTIVITY OF BROMOPYRROLE ALKALOIDS ISOLATED FROM CARIBBEAN AGELAS SPONGES, Bioorganic & medicinal chemistry letters, 7(17), 1997, pp. 2283-2288
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
17
Year of publication
1997
Pages
2283 - 2288
Database
ISI
SICI code
0960-894X(1997)7:17<2283:AAOBAI>2.0.ZU;2-#
Abstract
Four Caribbean Agelas sponges (A. clathrodes, A. conifera, A. dispar. A. longissima) have been investigated for the alkaloid composition. Al ong with a series of known bromopyrrole alkaloids, two related novel c ompounds of this class, dispacamides C (7) and D (8), were found and t heir structures determined with spectroscopic methods. All the isolate d Agelas bromopyrrole alkaloids have been evaluated for the antihistam inic activity on the guinea pig ileum. (C) 1997 Elsevier Science Ltd.