3-SUBSTITUTED-4-HYDROXY-7-CHROMANYLACETIC ACID-DERIVATIVES AS ANTAGONISTS OF THE LEUKOTRIENE B-4 (LTB4) RECEPTOR

Authors
REITER LA MELVIN LS CREAN GL SHOWELL HJ KOCH K BIGGERS MS CHENG JB BRESLOW R CONKLYN MJ FARRELL CA HADA WA LAIRD ER MARTIN JJ MILLER GT PILLAR JS
Citation
La. Reiter et al., 3-SUBSTITUTED-4-HYDROXY-7-CHROMANYLACETIC ACID-DERIVATIVES AS ANTAGONISTS OF THE LEUKOTRIENE B-4 (LTB4) RECEPTOR, Bioorganic & medicinal chemistry letters, 7(17), 1997, pp. 2307-2312
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
17
Year of publication
1997
Pages
2307 - 2312
Database
ISI
SICI code
0960-894X(1997)7:17<2307:3AAA>2.0.ZU;2-W
Abstract
The SAR of a series of 7-chromanylacetic acids has been investigated w ith the aim of identifying potent and selective LTB4 receptor antagoni sts. We found optimal activity in derivatives with alpha,alpha-disubst itution on the acetic acid and a C-4 hydroxy group and a C-3 lipophili c group on the chromane ring. CP-105696 (43), which contains a 4-pheny lbenzyl C-3 substituent, was selected for development. (C) 1997 Elsevi er Science Ltd.