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Results: 1-21 |
Results: 21
DESIGN AND SELECTION OF DMP-850 AND DMP-851 - THE NEXT-GENERATION OF CYCLIC UREA HIV PROTEASE INHIBITORS (VOL 5, PG 597, 1998)
Authors: RODGERS JD LAM PYS JOHNSON BL WANG HS LI RH RU Y KO SS SEITZ SP TRAINOR GL ANDERSON PS KLABE RM BACHELER LT CORDOVA B GARBER S REID C WRIGHT MR CHANG CH ERICKSONVIITANEN S
Citation: Jd. Rodgers et al., DESIGN AND SELECTION OF DMP-850 AND DMP-851 - THE NEXT-GENERATION OF CYCLIC UREA HIV PROTEASE INHIBITORS (VOL 5, PG 597, 1998), Chemistry & biology, 5(11), 1998, pp. 312-312
DESIGN AND SELECTION OF DMP-850 AND DMP-851 - THE NEXT-GENERATION OF CYCLIC UREA HIV PROTEASE INHIBITORS
Authors: RODGERS JD LAM PYS JOHNSON BL WANG HS KO SS SEITZ SP TRAINOR GL ANDERSON PS KLABE RM BACHELER LT CORDOVA B GARBER S REID C WRIGHT MR CHANG CH ERICKSONVIITANEN S
Citation: Jd. Rodgers et al., DESIGN AND SELECTION OF DMP-850 AND DMP-851 - THE NEXT-GENERATION OF CYCLIC UREA HIV PROTEASE INHIBITORS, Chemistry & biology, 5(10), 1998, pp. 597-608
THE SYNTHESIS OF SYMMETRICAL AND UNSYMMETRICAL P1 P1' CYCLIC UREAS ASHIV PROTEASE INHIBITORS/
Authors: PATEL M KALTENBACH RF NUGIEL DA MCHUGH RJ JADHAV PK BACHELER LT CORDOVA BC KLABE RM ERICKSONVIITANEN S GARBER S REID C SEITZ SP
Citation: M. Patel et al., THE SYNTHESIS OF SYMMETRICAL AND UNSYMMETRICAL P1 P1' CYCLIC UREAS ASHIV PROTEASE INHIBITORS/, Bioorganic & medicinal chemistry letters, 8(9), 1998, pp. 1077-1082
THE SYNTHESIS AND EVALUATION OF CYCLIC UREAS AS HIV PROTEASE INHIBITORS - MODIFICATIONS OF THE P1 P1' RESIDUES/
Authors: PATEL M BACHELER LT RAYNER MM CORDOVA BC KLABE RM ERICKSONVIITANEN S SEITZ SP
Citation: M. Patel et al., THE SYNTHESIS AND EVALUATION OF CYCLIC UREAS AS HIV PROTEASE INHIBITORS - MODIFICATIONS OF THE P1 P1' RESIDUES/, Bioorganic & medicinal chemistry letters, 8(7), 1998, pp. 823-828
NONPEPTIDE CYCLIC CYANOGUANIDINES AS HIV-1 PROTEASE INHIBITORS - SYNTHESIS, STRUCTURE-ACTIVITY-RELATIONSHIPS, AND X-RAY CRYSTAL-STRUCTURE STUDIES
Authors: JADHAV PK WOERNER FJ LAM PYS HODGE CN EYERMANN CJ MAN HW DANEKER WF BACHELER LT RAYNER MM MEEK JL ERICKSONVIITANEN S JACKSON DA CALABRESE JC SCHADT M CHANG CH
Citation: Pk. Jadhav et al., NONPEPTIDE CYCLIC CYANOGUANIDINES AS HIV-1 PROTEASE INHIBITORS - SYNTHESIS, STRUCTURE-ACTIVITY-RELATIONSHIPS, AND X-RAY CRYSTAL-STRUCTURE STUDIES, Journal of medicinal chemistry, 41(9), 1998, pp. 1446-1455
NONSYMMETRIC P2 P2' CYCLIC UREA HIV PROTEASE INHIBITORS - STRUCTURE-ACTIVITY RELATIONSHIP, BIOAVAILABILITY, AND RESISTANCE PROFILE OF MONOINDAZOLE-SUBSTITUTED P2 ANALOGS/
Authors: DELUCCA GV KIM UT LIANG J CORDOVA B KLABE RM GARBER S BACHELER LT LAM GN WRIGHT MR LOGUE KA ERICKSONVIITANEN S KO SS TRAINOR GL
Citation: Gv. Delucca et al., NONSYMMETRIC P2 P2' CYCLIC UREA HIV PROTEASE INHIBITORS - STRUCTURE-ACTIVITY RELATIONSHIP, BIOAVAILABILITY, AND RESISTANCE PROFILE OF MONOINDAZOLE-SUBSTITUTED P2 ANALOGS/, Journal of medicinal chemistry, 41(13), 1998, pp. 2411-2423
RESISTANCE TO HIV PROTEASE INHIBITORS - A COMPARISON OF ENZYME-INHIBITION AND ANTIVIRAL POTENCY
Authors: KLABE RM BACHELER LT ALA PJ ERICKSONVIITANEN S MEEK JL
Citation: Rm. Klabe et al., RESISTANCE TO HIV PROTEASE INHIBITORS - A COMPARISON OF ENZYME-INHIBITION AND ANTIVIRAL POTENCY, Biochemistry, 37(24), 1998, pp. 8735-8742
FUNCTIONALIZED ALIPHATIC P2 P2' ANALOGS OF HIV-1 PROTEASE INHIBITOR DMP323/
Authors: SMALLHEER JM MCHUGH RJ CHANG CH KALTENBACH RF WORLEY TV KLABE RM BACHELER LT RAYNER MM ERICKSONVIITANEN S SEITZ SP
Citation: Jm. Smallheer et al., FUNCTIONALIZED ALIPHATIC P2 P2' ANALOGS OF HIV-1 PROTEASE INHIBITOR DMP323/, Bioorganic & medicinal chemistry letters, 7(11), 1997, pp. 1365-1370
MOLECULAR RECOGNITION OF CYCLIC HIV PROTEASE INHIBITORS - NONSYMMETRIC CYCLIC UREAS WITH EXCELLENT ORAL BIOAVAILABILITY AND LOW DRUG-RESISTANCE PROFILES
Authors: LAM PYS RODGERS JD LI R RU Y JADHAV PK CHANG CH CLARK CG SEITZ SP KO SS BACHELER LT KLABE RM LAM GN WRIGHT MR ERICKSONVIITANEN S TRAINOR GL ANDERSON PS
Citation: Pys. Lam et al., MOLECULAR RECOGNITION OF CYCLIC HIV PROTEASE INHIBITORS - NONSYMMETRIC CYCLIC UREAS WITH EXCELLENT ORAL BIOAVAILABILITY AND LOW DRUG-RESISTANCE PROFILES, The FASEB journal, 11(9), 1997, pp. 48-48
CYCLIC UREA AMIDES - HIV-1 PROTEASE INHIBITORS WITH LOW NANOMOLAR POTENCY AGAINST BOTH WILD-TYPE AND PROTEASE INHIBITOR RESISTANT MUTANTS OF HIV
Authors: JADHAV PK ALA P WOERNER FJ CHANG CH GARBER SS ANTON ED BACHELER LT
Citation: Pk. Jadhav et al., CYCLIC UREA AMIDES - HIV-1 PROTEASE INHIBITORS WITH LOW NANOMOLAR POTENCY AGAINST BOTH WILD-TYPE AND PROTEASE INHIBITOR RESISTANT MUTANTS OF HIV, Journal of medicinal chemistry, 40(2), 1997, pp. 181-191
IMPROVED P1 P1' SUBSTITUENTS FOR CYCLIC UREA BASED HIV-1 PROTEASE INHIBITORS - SYNTHESIS, STRUCTURE-ACTIVITY RELATIONSHIP, AND X-RAY CRYSTAL-STRUCTURE ANALYSIS/
Authors: NUGIEL DA JACOBS K CORNELIUS L CHANG CH JADHAV PK HOLLER ER KLABE RM BACHELER LT CORDOVA B GARBER S REID C LOGUE KA GOREYFERET LJ LAM GN ERICKSONVIITANEN S SEITZ SP
Citation: Da. Nugiel et al., IMPROVED P1 P1' SUBSTITUENTS FOR CYCLIC UREA BASED HIV-1 PROTEASE INHIBITORS - SYNTHESIS, STRUCTURE-ACTIVITY RELATIONSHIP, AND X-RAY CRYSTAL-STRUCTURE ANALYSIS/, Journal of medicinal chemistry, 40(10), 1997, pp. 1465-1474
IMPROVED CYCLIC UREA INHIBITORS OF THE HIV-I PROTEASE - SYNTHESIS, POTENCY, RESISTANCE PROFILE, HUMAN PHARMACOKINETICS AND X-RAY CRYSTAL-STRUCTURE OF DMP-450
Authors: HODGE CN ALDRICH PE BACHELER LT CHANG CH EYERMANN CJ GARBER S GRUBB M JACKSON DA JADHAV PK KORANT B LAM PYS MAURIN MB MEEK JL OTTO MJ RAYNER MM REID C SHARPE TR SHUM L WINSLOW DL ERICKSONVIITANEN S
Citation: Cn. Hodge et al., IMPROVED CYCLIC UREA INHIBITORS OF THE HIV-I PROTEASE - SYNTHESIS, POTENCY, RESISTANCE PROFILE, HUMAN PHARMACOKINETICS AND X-RAY CRYSTAL-STRUCTURE OF DMP-450, Chemistry & biology, 3(4), 1996, pp. 301-314
SYNTHESIS OF (-BIOTIN DERIVATIVES AS HIV-1 PROTEASE INHIBITORS())
Authors: HAN Q LAFONTAINE J BACHELER LT RAYNER MM KLABE RM ERICKSONVIITANEN S LAM PYS
Citation: Q. Han et al., SYNTHESIS OF (-BIOTIN DERIVATIVES AS HIV-1 PROTEASE INHIBITORS()), Bioorganic & medicinal chemistry letters, 6(12), 1996, pp. 1371-1374
CYCLIC HIV PROTEASE INHIBITORS - SYNTHESIS, CONFORMATIONAL-ANALYSIS, P2 P2' STRUCTURE-ACTIVITY RELATIONSHIP, AND MOLECULAR RECOGNITION OF CYCLIC UREAS/
Authors: LAM PYS RU Y JADHAV PK ALDRICH PE DELUCCA GV EYERMANN CJ CHANG CH EMMETT G HOLLER ER DANEKER WF LI LZ CONFALONE PN MCHUGH RJ HAN Q LI RH MARKWALDER JA SEITZ SP SHARPE TR BACHELER LT RAYNER MM KLABE RM SHUM LY WINSLOW DL KORNHAUSER DM JACKSON DA ERICKSONVIITANEN S HODGE CN
Citation: Pys. Lam et al., CYCLIC HIV PROTEASE INHIBITORS - SYNTHESIS, CONFORMATIONAL-ANALYSIS, P2 P2' STRUCTURE-ACTIVITY RELATIONSHIP, AND MOLECULAR RECOGNITION OF CYCLIC UREAS/, Journal of medicinal chemistry, 39(18), 1996, pp. 3514-3525
PREPARATION AND STRUCTURE-ACTIVITY RELATIONSHIP OF NOVEL P1 P1'-SUBSTITUTED CYCLIC UREA-BASED HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE INHIBITORS/
Authors: NUGIEL DA JACOBS K WORLEY T PATEL M KALTENBACH RF MEYER DT JADHAV PK DELUCCA GV SMYSER TE KLABE RM BACHELER LT RAYNER MM SEITZ SP
Citation: Da. Nugiel et al., PREPARATION AND STRUCTURE-ACTIVITY RELATIONSHIP OF NOVEL P1 P1'-SUBSTITUTED CYCLIC UREA-BASED HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE INHIBITORS/, Journal of medicinal chemistry, 39(11), 1996, pp. 2156-2169
MULTIPLE MUTATIONS IN THE HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE GENE ARE RESPONSIBLE FOR DECREASED SUSCEPTIBILITY TO PROTEASE INHIBITORS
Authors: KING RW GARBER S WINSLOW DL REID C BACHELER LT ANTON E OTTO MJ
Citation: Rw. King et al., MULTIPLE MUTATIONS IN THE HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE GENE ARE RESPONSIBLE FOR DECREASED SUSCEPTIBILITY TO PROTEASE INHIBITORS, Antiviral chemistry & chemotherapy, 6(2), 1995, pp. 80-88
AN ASSAY FOR HIV RNA IN INFECTED CELL LYSATES, AND ITS USE FOR THE RAPID EVALUATION OF ANTIVIRAL EFFICACY
Authors: BACHELER LT PAUL M OTTO MJ JADHAV PK STONE BA MILLER JA
Citation: Lt. Bacheler et al., AN ASSAY FOR HIV RNA IN INFECTED CELL LYSATES, AND ITS USE FOR THE RAPID EVALUATION OF ANTIVIRAL EFFICACY, Antiviral chemistry & chemotherapy, 5(2), 1994, pp. 111-121
RATIONAL DESIGN OF POTENT, BIOAVAILABLE NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS
Authors: ERICKSONVIITANEN S LAM PYS JADHAV PK EYERMANN CJ HODGE CN RU Y BACHELER LT MEEK JL OTTO MJ RAYNER MM WONG YN CHANG CH WEBER PC JACKSON DA SHARPE TR
Citation: S. Ericksonviitanen et al., RATIONAL DESIGN OF POTENT, BIOAVAILABLE NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS, Journal of cellular biochemistry, 1994, pp. 167-167
RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS
Authors: LAM PYS JADHAV PK EYERMANN CJ HODGE CN RU Y BACHELER LT MEEK JL OTTO MJ RAYNER MM WONG YN CHANG CH WEBER PC JACKSON DA SHARPE TR ERICKSONVIITANEN S
Citation: Pys. Lam et al., RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS, Science, 263(5145), 1994, pp. 380-384
CONSTRUCTION OF INFECTIOUS MOLECULAR CLONES OF HIV-1 CONTAINING DEFINED MUTATIONS IN THE PROTEASE GENE
Authors: WINSLOW DL ANTON ED HORLICK RA ZAGURSKY RJ TRITCH RJ SCARNATI H ACKERMAN K BACHELER LT
Citation: Dl. Winslow et al., CONSTRUCTION OF INFECTIOUS MOLECULAR CLONES OF HIV-1 CONTAINING DEFINED MUTATIONS IN THE PROTEASE GENE, Biochemical and biophysical research communications, 205(3), 1994, pp. 1651-1657
IN-VITRO ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) ACTIVITY OF XM323, ANOVEL HIV PROTEASE INHIBITOR
Authors: OTTO MJ REID CD GARBER S LAM PYS SCARNATI H BACHELER LT RAYNER MM WINSLOW DL
Citation: Mj. Otto et al., IN-VITRO ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) ACTIVITY OF XM323, ANOVEL HIV PROTEASE INHIBITOR, Antimicrobial agents and chemotherapy, 37(12), 1993, pp. 2606-2611
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