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Results: 1-20 |
Results: 20
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS - SUBSTITUTED QUINAZOLINEDIONES AND QUINAZOLINONES AS POTENT FIBRINOGEN RECEPTOR ANTAGONISTS/
Authors: LIVERTON NJ ARMSTRONG DJ CLAREMON DA REMY DC BALDWIN JJ
Citation: Nj. Liverton et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS - SUBSTITUTED QUINAZOLINEDIONES AND QUINAZOLINONES AS POTENT FIBRINOGEN RECEPTOR ANTAGONISTS/, Bioorganic & medicinal chemistry letters, 8(5), 1998, pp. 483-486
DESIGN, SYNTHESES, AND ACTIVITY OF NEW 3-[(SULFONYLARYL)-AMINO]-1,4-BENZODIAZEPIN-2-ONE DERIVATIVES AS ALPHA-THROMBIN INHIBITORS
Authors: DUMAS D LECLERC G BALDWIN JJ LEWIS SD MURCKO M NAYLOROLSEN AM
Citation: D. Dumas et al., DESIGN, SYNTHESES, AND ACTIVITY OF NEW 3-[(SULFONYLARYL)-AMINO]-1,4-BENZODIAZEPIN-2-ONE DERIVATIVES AS ALPHA-THROMBIN INHIBITORS, European journal of medicinal chemistry, 33(6), 1998, pp. 471-488
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .13. DESIGN AND SYNTHESISOF AN ORALLY-ACTIVE PYRAZOLOPIPERAZINONE NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONIST/
Authors: ASKEW BC MCINTYRE CJ HUNT CA CLAREMON DA BALDWIN JJ ANDERSON PS GOULD RJ LYNCH RJ CHANG CCT COOK JJ LYNCH JJ HOLAHAN MA SITKO GR STRANIERI MT
Citation: Bc. Askew et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .13. DESIGN AND SYNTHESISOF AN ORALLY-ACTIVE PYRAZOLOPIPERAZINONE NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONIST/, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1531-1536
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .15. ANTITHROMBOTIC EFFICACY OF L-738,167, A LONG-ACTING GPIIB/IIIA ANTAGONIST, CORRELATES WITHINHIBITION OF ADENOSINE DIPHOSPHATE-INDUCED PLATELET-AGGREGATION BUT NOT WITH BLEEDING-TIME PROLONGATION/
Authors: COOK JJ SITKO GR HOLAHAN MA STRANIERI MT GLASS JD ASKEW BC MCINTYRE CJ CLAREMON DA BALDWIN JJ HARTMAN GD GOULD RJ LYNCH JJ
Citation: Jj. Cook et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .15. ANTITHROMBOTIC EFFICACY OF L-738,167, A LONG-ACTING GPIIB/IIIA ANTAGONIST, CORRELATES WITHINHIBITION OF ADENOSINE DIPHOSPHATE-INDUCED PLATELET-AGGREGATION BUT NOT WITH BLEEDING-TIME PROLONGATION/, The Journal of pharmacology and experimental therapeutics, 281(2), 1997, pp. 677-689
CLASS-III ANTIARRHYTHMIC ACTIVITY IN-VIVO BY SELECTIVE BLOCKADE OF THE SLOWLY ACTIVATING CARDIAC DELAYED RECTIFIER POTASSIUM CURRENT I-KS BY ,3-DIHYDRO-1H-BENZO[E][1,4]DIAZEPIN-3-YL]ACETAMIDE
Authors: SELNICK HG LIVERTON NJ BALDWIN JJ BUTCHER JW CLAREMON DA ELLIOTT JM FREIDINGER RM KING SA LIBBY BE MCINTYRE CJ PRIBUSH DA REMY DC SMITH GR TEBBEN AJ JURKIEWICZ NK LYNCH JJ SALATA JJ SANGUINETTI MC SIEGL PKS SLAUGHTER DE VYAS K
Citation: Hg. Selnick et al., CLASS-III ANTIARRHYTHMIC ACTIVITY IN-VIVO BY SELECTIVE BLOCKADE OF THE SLOWLY ACTIVATING CARDIAC DELAYED RECTIFIER POTASSIUM CURRENT I-KS BY ,3-DIHYDRO-1H-BENZO[E][1,4]DIAZEPIN-3-YL]ACETAMIDE, Journal of medicinal chemistry, 40(24), 1997, pp. 3865-3868
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .17. DESIGN AND SYNTHESISOF ORALLY-ACTIVE, LONG-ACTING NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS/
Authors: ASKEW BC BEDNAR RA BEDNAR B CLAREMON DA COOK JJ MCINTYRE CJ HUNT CA GOULD RJ LYNCH RJ LYNCH JJ GAUL SL STRANIERI MT SITKO GR HOLAHAN MA GLASS JD HAMILL T GORHAM LM PRUEKSARITANONT T BALDWIN JJ HARTMAN GD
Citation: Bc. Askew et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .17. DESIGN AND SYNTHESISOF ORALLY-ACTIVE, LONG-ACTING NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS/, Journal of medicinal chemistry, 40(12), 1997, pp. 1779-1788
DESIGN, SYNTHESIS AND USE OF BINARY ENCODED SYNTHETIC CHEMICAL LIBRARIES
Authors: BALDWIN JJ
Citation: Jj. Baldwin, DESIGN, SYNTHESIS AND USE OF BINARY ENCODED SYNTHETIC CHEMICAL LIBRARIES, Molecular diversity, 2(1-2), 1996, pp. 81-88
RECENT ADVANCES IN THE GENERATION OF SMALL-MOLECULE COMBINATORIAL LIBRARIES - ENCODED SPLIT SYNTHESIS AND SOLID-PHASE SYNTHETIC METHODOLOGY
Authors: BALDWIN JJ HENDERSON I
Citation: Jj. Baldwin et I. Henderson, RECENT ADVANCES IN THE GENERATION OF SMALL-MOLECULE COMBINATORIAL LIBRARIES - ENCODED SPLIT SYNTHESIS AND SOLID-PHASE SYNTHETIC METHODOLOGY, Medicinal research reviews, 16(5), 1996, pp. 391-405
COMBINATORIAL LIBRARIES ENCODED WITH ELECTROPHORIC TAGS
Authors: BALDWIN JJ BURBAUM JJ CHELSKY D DILLARD LW HENDERSON I LI G OHLMEYER MHJ RANDLE TL READER JC
Citation: Jj. Baldwin et al., COMBINATORIAL LIBRARIES ENCODED WITH ELECTROPHORIC TAGS, European journal of medicinal chemistry, 30, 1995, pp. 349-358
A PARADIGM FOR DRUG DISCOVERY EMPLOYING ENCODED COMBINATORIAL LIBRARIES
Authors: BURBAUM JJ OHLMEYER MHJ READER JC HENDERSON I DILLARD LW LI G RANDLE TL SIGAL NH CHELSKY D BALDWIN JJ
Citation: Jj. Burbaum et al., A PARADIGM FOR DRUG DISCOVERY EMPLOYING ENCODED COMBINATORIAL LIBRARIES, Proceedings of the National Academy of Sciences of the United Statesof America, 92(13), 1995, pp. 6027-6031
APPLICATION OF THE FREE-ENERGY PERTURBATION METHOD TO HUMAN CARBONIC-ANHYDRASE-II INHIBITORS
Authors: ROSSI KA MERZ KM SMITH GM BALDWIN JJ
Citation: Ka. Rossi et al., APPLICATION OF THE FREE-ENERGY PERTURBATION METHOD TO HUMAN CARBONIC-ANHYDRASE-II INHIBITORS, Journal of medicinal chemistry, 38(12), 1995, pp. 2061-2069
SYNTHESIS OF A SMALL-MOLECULE COMBINATORIAL LIBRARY ENCODED WITH MOLECULAR TAGS
Authors: BALDWIN JJ BURBAUM JJ HENDERSON I OHLMEYER MHJ
Citation: Jj. Baldwin et al., SYNTHESIS OF A SMALL-MOLECULE COMBINATORIAL LIBRARY ENCODED WITH MOLECULAR TAGS, Journal of the American Chemical Society, 117(20), 1995, pp. 5588-5589
POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC-ANHYDRASE-II UPON BINDING 3 STRUCTURALLY RELATED INHIBITORS
Authors: SMITH GM ALEXANDER RS CHRISTIANSON DW MCKEEVER BM PONTICELLO GS SPRINGER JP RANDALL WC BALDWIN JJ HABECKER CN
Citation: Gm. Smith et al., POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC-ANHYDRASE-II UPON BINDING 3 STRUCTURALLY RELATED INHIBITORS, Protein science, 3(1), 1994, pp. 118-125
CARDIAC ELECTROPHYSIOLOGIC AND ANTIARRHYTHMIC ACTIONS OF 2 LONG-ACTING SPIROBENZOPYRAN PIPERIDINE CLASS-III AGENTS, L-702,958 AND L-706,000[MK-499]
Authors: LYNCH JJ WALLACE AA STUPIENSKI RF BASKIN EP BEARE CM APPLEBY SD SALATA JJ JURKIEWICZ NK SANGUINETTI MC STEIN RB GEHRET JR KOTHSTEIN T CLAREMON DA ELLIOTT JM BUTCHER JW REMY DC BALDWIN JJ
Citation: Jj. Lynch et al., CARDIAC ELECTROPHYSIOLOGIC AND ANTIARRHYTHMIC ACTIONS OF 2 LONG-ACTING SPIROBENZOPYRAN PIPERIDINE CLASS-III AGENTS, L-702,958 AND L-706,000[MK-499], The Journal of pharmacology and experimental therapeutics, 269(2), 1994, pp. 541-554
APPLICATION OF THE 3-DIMENSIONAL STRUCTURES OF PROTEIN TARGET MOLECULES IN STRUCTURE-BASED DRUG DESIGN
Authors: GREER J ERICKSON JW BALDWIN JJ VARNEY MD
Citation: J. Greer et al., APPLICATION OF THE 3-DIMENSIONAL STRUCTURES OF PROTEIN TARGET MOLECULES IN STRUCTURE-BASED DRUG DESIGN, Journal of medicinal chemistry, 37(8), 1994, pp. 1035-1054
TRANSGLUTAMINASE INHIBITION BY 2-[(2-OXOPROPYL)THIO]IMIDAZOLIUM DERIVATIVES - MECHANISM OF FACTOR XIIIA INACTIVATION
Authors: FREUND KF DOSHI KP GAUL SL CLAREMON DA REMY DC BALDWIN JJ PITZENBERGER SM STERN AM
Citation: Kf. Freund et al., TRANSGLUTAMINASE INHIBITION BY 2-[(2-OXOPROPYL)THIO]IMIDAZOLIUM DERIVATIVES - MECHANISM OF FACTOR XIIIA INACTIVATION, Biochemistry, 33(33), 1994, pp. 10109-10119
INHIBITION OF THROMBIN AND OTHER TRYPSIN-LIKE SERINE PROTEINASES BY CYCLOTHEONAMIDE
Authors: LEWIS ASD NG AS BALDWIN JJ FUSETAN N NAYLOR AM SHAFER JA
Citation: Asd. Lewis et al., INHIBITION OF THROMBIN AND OTHER TRYPSIN-LIKE SERINE PROTEINASES BY CYCLOTHEONAMIDE, Thrombosis and haemostasis, 69(6), 1993, pp. 668-668
INHIBITION OF THROMBIN AND OTHER TRYPSIN-LIKE SERINE PROTEINASES BY CYCLOTHEONAMIDE-A
Authors: LEWIS SD NG AS BALDWIN JJ FUSETANI N NAYLOR AM SHAFER JA
Citation: Sd. Lewis et al., INHIBITION OF THROMBIN AND OTHER TRYPSIN-LIKE SERINE PROTEINASES BY CYCLOTHEONAMIDE-A, Thrombosis research, 70(2), 1993, pp. 173-190
CARDIAC ELECTROPHYSIOLOGIC AND ANTIARRHYTHMIC ACTIONS OF 3,4-DIHYDRO-1'-[2-(BENZOFURAZAN-5-YL) AMIDOSPIRO[(2H)-1-BENZOPYRAN-2,4'-PIPERIDIN]-4-ONE HCL (L-691, 121), A NOVEL CLASS-III AGENT
Authors: LYNCH JJ WALLACE AA VANDERGAAG LH BASKIN EP BEAR CM GEHRET JR KOTHSTEIN T STUPIENSKI RF APPLEBY SD SANGUINETTI MC JURKIEWICZ NK ZINGARO GJ STEIN RB CLAREMON DA ELLIOTT JM YOUNG MB BALDWIN JJ
Citation: Jj. Lynch et al., CARDIAC ELECTROPHYSIOLOGIC AND ANTIARRHYTHMIC ACTIONS OF 3,4-DIHYDRO-1'-[2-(BENZOFURAZAN-5-YL) AMIDOSPIRO[(2H)-1-BENZOPYRAN-2,4'-PIPERIDIN]-4-ONE HCL (L-691, 121), A NOVEL CLASS-III AGENT, The Journal of pharmacology and experimental therapeutics, 265(2), 1993, pp. 720-730
L-693,612, A TOPICAL OCULAR HYPOTENSIVE CARBONIC-ANHYDRASE INHIBITOR (CAI) WITH A PROLONGED DURATION OF ACTION IN GLAUCOMATOUS MONKEYS
Authors: SUGRUE MF MALLORGA P SCHWAM H BALDWIN JJ PONTICELLO GS WOLTERSDORF OW
Citation: Mf. Sugrue et al., L-693,612, A TOPICAL OCULAR HYPOTENSIVE CARBONIC-ANHYDRASE INHIBITOR (CAI) WITH A PROLONGED DURATION OF ACTION IN GLAUCOMATOUS MONKEYS, Investigative ophthalmology & visual science, 33(4), 1992, pp. 1246-1246
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