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Results: 1-23 |
Results: 23
CYCLOPROPANE-DERIVED PEPTIDOMIMETICS - DESIGN, SYNTHESIS, EVALUATION,AND STRUCTURE OF NOVEL HIV-1 PROTEASE INHIBITORS
Authors: MARTIN SF DORSEY GO GANE T HILLIER MC KESSLER H BAUR M MATHA B ERICKSON JW BHAT TN MUNSHI S GULNIK SV TOPOL IA
Citation: Sf. Martin et al., CYCLOPROPANE-DERIVED PEPTIDOMIMETICS - DESIGN, SYNTHESIS, EVALUATION,AND STRUCTURE OF NOVEL HIV-1 PROTEASE INHIBITORS, Journal of medicinal chemistry, 41(10), 1998, pp. 1581-1597
4-HYDROXY-5,6-DIHYDROPYRONES .2. POTENT NONPEPTIDE INHIBITORS OF HIV PROTEASE
Authors: TAIT BD HAGEN S DOMAGALA J ELLSWORTH EL GAJDA C HAMILTON HW PRASAD JVNV FERGUSON D GRAHAM N HUPE D NOUHAN C TUMMINO PJ HUMBLET C LUNNEY EA PAVLOVSKY A RUBIN J GRACHECK SJ BALDWIN ET BHAT TN ERICKSON JW GULNIK SV LIU BS
Citation: Bd. Tait et al., 4-HYDROXY-5,6-DIHYDROPYRONES .2. POTENT NONPEPTIDE INHIBITORS OF HIV PROTEASE, Journal of medicinal chemistry, 40(23), 1997, pp. 3781-3792
STRUCTURE AND INHIBITION OF PLASMEPSIN-II, A HEMOGLOBIN-DEGRADING ENZYME FROM PLASMODIUM-FALCIPARUM
Authors: SILVA AM LEE AY GULNIK SV MAJER P COLLINS J BHAT TN COLLINS PJ CACHAU RE LUKER KE GLUZMAN IY FRANCIS SE OKSMAN A GOLDBERG DE ERICKSON JW
Citation: Am. Silva et al., STRUCTURE AND INHIBITION OF PLASMEPSIN-II, A HEMOGLOBIN-DEGRADING ENZYME FROM PLASMODIUM-FALCIPARUM, Proceedings of the National Academy of Sciences of the United Statesof America, 93(19), 1996, pp. 10034-10039
SOCIOECONOMIC CONDITION OF THE HOUSELESS POPULATION IN RURAL-AREAS
Authors: SAMUEL MJ LINGARAJU M BHAT TN
Citation: Mj. Samuel et al., SOCIOECONOMIC CONDITION OF THE HOUSELESS POPULATION IN RURAL-AREAS, Indian journal of social work, 57(2), 1996, pp. 221-233
BOUND WATER-MOLECULES AT THE INTERFACE BETWEEN THE HIV-1 PROTEASE ANDA POTENT INHIBITOR, KNI-272, DETERMINED BY NMR
Authors: WANG YX FREEDBERG DI WINGFIELD PT STAHL SJ KAUFMAN JD KISO Y BHAT TN ERICKSON JW TORCHIA DA
Citation: Yx. Wang et al., BOUND WATER-MOLECULES AT THE INTERFACE BETWEEN THE HIV-1 PROTEASE ANDA POTENT INHIBITOR, KNI-272, DETERMINED BY NMR, Journal of the American Chemical Society, 118(49), 1996, pp. 12287-12290
STRUCTURAL MECHANISMS OF DRUG-RESISTANCE FOR HIV-1 PROTEASE MUTANTS
Authors: ERICKSON JW BHAT TN MUNSHI S GULNIK S
Citation: Jw. Erickson et al., STRUCTURAL MECHANISMS OF DRUG-RESISTANCE FOR HIV-1 PROTEASE MUTANTS, Journal of acquired immune deficiency syndromes and human retrovirology, 10, 1995, pp. 63-63
STRUCTURAL BASIS OF DRUG-RESISTANCE FOR THE V82A MUTANT OF HIV-1 PROTEINASE
Authors: BALDWIN ET BHAT TN LIU BS PATTABIRAMAN N ERICKSON JW
Citation: Et. Baldwin et al., STRUCTURAL BASIS OF DRUG-RESISTANCE FOR THE V82A MUTANT OF HIV-1 PROTEINASE, Nature structural biology, 2(3), 1995, pp. 244-249
STRUCTURE OF HIV-1 PROTEASE WITH KNI-272, A TIGHT-BINDING TRANSITION-STATE ANALOG CONTAINING ALLOPHENYLNORSTATINE
Authors: BALDWIN ET BHAT TN GULNIK S LIU BS TOPOL IA KISO Y MIMOTO T MITSUYA H ERICKSON JW
Citation: Et. Baldwin et al., STRUCTURE OF HIV-1 PROTEASE WITH KNI-272, A TIGHT-BINDING TRANSITION-STATE ANALOG CONTAINING ALLOPHENYLNORSTATINE, Structure, 3(6), 1995, pp. 581-590
STRUCTURE-BASED DESIGN OF ACHIRAL ANTHRANILAMIDES AS P2 P2' SURROGATES FOR SYMMETRY-BASED HIV PROTEASE INHIBITORS - DESIGN, SYNTHESIS, X-RAY STRUCTURE, ENZYME-INHIBITION AND ANTIVIRAL ACTIVITY/
Authors: RANDAD RS LUBKOWSKA L BUJACZ A NAIK RH GULNIK SV YU B SILVA A MUNSHI S LYNCH TM CLANTON DJ BHAT TN ERICKSON JW
Citation: Rs. Randad et al., STRUCTURE-BASED DESIGN OF ACHIRAL ANTHRANILAMIDES AS P2 P2' SURROGATES FOR SYMMETRY-BASED HIV PROTEASE INHIBITORS - DESIGN, SYNTHESIS, X-RAY STRUCTURE, ENZYME-INHIBITION AND ANTIVIRAL ACTIVITY/, Bioorganic & medicinal chemistry letters, 5(21), 1995, pp. 2557-2562
SYMMETRY-BASED HIV PROTEASE INHIBITORS - RATIONAL DESIGN OF 2-METHYLBENZAMIDES AS NOVEL P2 P2' LIGANDS/
Authors: RANDAD RS LUBKOWSKA L BHAT TN MUNSHI S GULNIK SV YU B ERICKSON JW
Citation: Rs. Randad et al., SYMMETRY-BASED HIV PROTEASE INHIBITORS - RATIONAL DESIGN OF 2-METHYLBENZAMIDES AS NOVEL P2 P2' LIGANDS/, Bioorganic & medicinal chemistry letters, 5(15), 1995, pp. 1707-1712
SELECTION AND ANALYSIS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-I VARIANTS WITH INCREASED RESISTANCE TO ABT-538, A NOVEL PROTEASE INHIBITOR
Authors: MARKOWITZ M MO HM KEMPF DJ NORBECK DW BHAT TN ERICKSON JW HO DD
Citation: M. Markowitz et al., SELECTION AND ANALYSIS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-I VARIANTS WITH INCREASED RESISTANCE TO ABT-538, A NOVEL PROTEASE INHIBITOR, Journal of virology, 69(2), 1995, pp. 701-706
NONPEPTIDIC POTENT HIV-1 PROTEASE INHIBITORS - -HYDROXY-6-PHENYL-2-OXO-2H-PYRAN-3-YL)THIOMETHANES THAT SPAN P-1-P-2' SUBSITES IN A UNIQUE MODE OF ACTIVE-SITE BINDING
Authors: PRASAD JVN PARA KS TUMMINO PJ FERGUSON D MCQUADE TJ LUNNEY EA RAPUNDALO ST BATLEY BL HINGORANI G DOMAGALA JM GRACHECK SJ BHAT TN LIU BS BALDWIN ET ERICKSON JW SAWYER TK
Citation: Jvn. Prasad et al., NONPEPTIDIC POTENT HIV-1 PROTEASE INHIBITORS - -HYDROXY-6-PHENYL-2-OXO-2H-PYRAN-3-YL)THIOMETHANES THAT SPAN P-1-P-2' SUBSITES IN A UNIQUE MODE OF ACTIVE-SITE BINDING, Journal of medicinal chemistry, 38(6), 1995, pp. 898-905
HIV PROTEASE INHIBITORS POSSESSING A NOVEL, HIGH-AFFINITY, AND ACHIRAL P-1' P-2' LIGAND WITH A UNIQUE PATTERN OF IN-VITRO RESISTANCE - IMPORTANCE OF A CONFORMATIONALLY-RESTRICTED TEMPLATE IN THE DESIGN OF ENZYME-INHIBITORS/
Authors: PRASAD JVNV LUNNEY EA FERGUSON D TUMMINO PJ RUBIN JR REYNER EL STEWART BH GUTTENDORF RJ DOMAGALA JM SUVOROV LI GULNIK SV TOPOL IA BHAT TN ERICKSON JW
Citation: Jvnv. Prasad et al., HIV PROTEASE INHIBITORS POSSESSING A NOVEL, HIGH-AFFINITY, AND ACHIRAL P-1' P-2' LIGAND WITH A UNIQUE PATTERN OF IN-VITRO RESISTANCE - IMPORTANCE OF A CONFORMATIONALLY-RESTRICTED TEMPLATE IN THE DESIGN OF ENZYME-INHIBITORS/, Journal of the American Chemical Society, 117(45), 1995, pp. 11070-11074
CRYSTAL-STRUCTURE OF A TETHERED DIMER OF HIV-1 PROTEINASE COMPLEXED WITH AND INHIBITOR
Authors: BHAT TN BALDWIN ET LIU BS CHENG YSE ERICKSON JW
Citation: Tn. Bhat et al., CRYSTAL-STRUCTURE OF A TETHERED DIMER OF HIV-1 PROTEINASE COMPLEXED WITH AND INHIBITOR, Nature structural biology, 1(8), 1994, pp. 552-556
BOUND WATER-MOLECULES AND CONFORMATIONAL STABILIZATION HELP MEDIATE AN ANTIGEN-ANTIBODY ASSOCIATION
Authors: BHAT TN BENTLEY GA BOULOT G GREENE MI TELLO D DALLACQUA W SOUCHON H SCHWARZ FP MARIUZZA RA POLJAK RJ
Citation: Tn. Bhat et al., BOUND WATER-MOLECULES AND CONFORMATIONAL STABILIZATION HELP MEDIATE AN ANTIGEN-ANTIBODY ASSOCIATION, Proceedings of the National Academy of Sciences of the United Statesof America, 91(3), 1994, pp. 1089-1093
3-DIMENSIONAL STRUCTURES OF THE FREE AND THE ANTIGEN-COMPLEXED FAB FROM MONOCLONAL ANTILYSOZYME ANTIBODY-D44.1
Authors: BRADEN BC SOUCHON H EISELE JL BENTLEY GA BHAT TN NAVAZA J POLJAK RJ
Citation: Bc. Braden et al., 3-DIMENSIONAL STRUCTURES OF THE FREE AND THE ANTIGEN-COMPLEXED FAB FROM MONOCLONAL ANTILYSOZYME ANTIBODY-D44.1, Journal of Molecular Biology, 243(4), 1994, pp. 767-781
SOLVENT REARRANGEMENT IN AN ANTIGEN-ANTIBODY INTERFACE INTRODUCED BY SITE-DIRECTED MUTAGENESIS OF THE ANTIBODY COMBINING SITE
Authors: YSERN X FIELDS BA BHAT TN GOLDBAUM FA DALLACQUA W SCHWARZ FP POLJAK RJ MARIUZZA BA
Citation: X. Ysern et al., SOLVENT REARRANGEMENT IN AN ANTIGEN-ANTIBODY INTERFACE INTRODUCED BY SITE-DIRECTED MUTAGENESIS OF THE ANTIBODY COMBINING SITE, Journal of Molecular Biology, 238(4), 1994, pp. 496-500
A NOVEL NONPEPTIDE HIV-1 PROTEASE INHIBITOR - ELUCIDATION OF THE BINDING MODE AND ITS APPLICATION IN THE DESIGN OF RELATED ANALOGS
Authors: LUNNEY EA HAGEN SE DOMAGALA JM HUMBLET C KOSINSKI J TAIT BD WARMUS JS WILSON M FERGUSON D HUPE D TUMMINO PJ BALDWIN ET BHAT TN LIU BS ERICKSON JW
Citation: Ea. Lunney et al., A NOVEL NONPEPTIDE HIV-1 PROTEASE INHIBITOR - ELUCIDATION OF THE BINDING MODE AND ITS APPLICATION IN THE DESIGN OF RELATED ANALOGS, Journal of medicinal chemistry, 37(17), 1994, pp. 2664-2677
DIFFERENTIAL ACCEPTANCE OF FAMILY-PLANNING METHODS IN A HIGH-PERFORMANCE DISTRICT IN KARNATAKA
Authors: RAJU KNM BHAT TN UMAMANI KS LINGARAJU M
Citation: Knm. Raju et al., DIFFERENTIAL ACCEPTANCE OF FAMILY-PLANNING METHODS IN A HIGH-PERFORMANCE DISTRICT IN KARNATAKA, Journal of Family Welfare, 40(2), 1994, pp. 31-39
INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C(2) SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
Authors: HOSUR MV BHAT TN KEMPF DJ BALDWIN ET LIU BS GULNIK S WIDEBURG NE NORBECK DW APPELT K ERICKSON JW
Citation: Mv. Hosur et al., INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C(2) SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE, Journal of the American Chemical Society, 116(3), 1994, pp. 847-855
NOVEL SERIES OF ACHIRAL, LOW-MOLECULAR-WEIGHT, AND POTENT HIV-1 PROTEASE INHIBITORS
Authors: PRASAD JVNV PARA KS LUNNEY EA ORTWINE DF DUNBAR JB FERGUSON D TUMMINO PJ HUPE D TAIT BD DOMAGALA JM HUMBLET C BHAT TN LIU BS GUERIN DMA BALDWIN ET ERICKSON JW SAWYER TK
Citation: Jvnv. Prasad et al., NOVEL SERIES OF ACHIRAL, LOW-MOLECULAR-WEIGHT, AND POTENT HIV-1 PROTEASE INHIBITORS, Journal of the American Chemical Society, 116(15), 1994, pp. 6989-6990
3-DIMENSIONAL STRUCTURE OF A HETEROCLITIC ANTIGEN-ANTIBODY CROSS-REACTION COMPLEX
Authors: CHITARRA V ALZARI PM BENTLEY GA BHAT TN EISELE JL HOUDUSSE A LESCAR J SOUCHON H POLJAK RJ
Citation: V. Chitarra et al., 3-DIMENSIONAL STRUCTURE OF A HETEROCLITIC ANTIGEN-ANTIBODY CROSS-REACTION COMPLEX, Proceedings of the National Academy of Sciences of the United Statesof America, 90(16), 1993, pp. 7711-7715
CRYSTAL-STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN-D- IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN
Authors: BALDWIN ET BHAT TN GULNIK S HOSUR MV SOWDER RC CACHAU RE COLLINS J SILVA AM ERICKSON JW
Citation: Et. Baldwin et al., CRYSTAL-STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN-D- IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN, Proceedings of the National Academy of Sciences of the United Statesof America, 90(14), 1993, pp. 6796-6800
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