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THE 5-HT2C RECEPTOR GENE - FROM MOUSE TO MAN - NOVEL THERAPEUTIC OPPORTUNITIES
Authors: BLACKBURN TP
Citation: Tp. Blackburn, THE 5-HT2C RECEPTOR GENE - FROM MOUSE TO MAN - NOVEL THERAPEUTIC OPPORTUNITIES, European journal of neuroscience, 10, 1998, pp. 12903-12903
NOVEL AND SELECTIVE 5-HT2C 2B RECEPTOR ANTAGONISTS AS POTENTIAL ANXIOLYTIC AGENTS - SYNTHESIS, QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS, AND MOLECULAR MODELING OF SUBSTITUTED 1-(3-PYRIDYLCARBAMOYL)INDOLINES/
Authors: BROMIDGE SM DABBS S DAVIES DT DUCKWORTH DM FORBES IT HAM P JONES GE KING FD SAUNDERS DV STARR S THEWLIS KM WYMAN PA BLANEY FE NAYLOR CB BAILEY F BLACKBURN TP HOLLAND V KENNETT GA RILEY GJ WOOD MD
Citation: Sm. Bromidge et al., NOVEL AND SELECTIVE 5-HT2C 2B RECEPTOR ANTAGONISTS AS POTENTIAL ANXIOLYTIC AGENTS - SYNTHESIS, QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS, AND MOLECULAR MODELING OF SUBSTITUTED 1-(3-PYRIDYLCARBAMOYL)INDOLINES/, Journal of medicinal chemistry, 41(10), 1998, pp. 1598-1612
SB-205384 - A GABA(A) RECEPTOR MODULATOR WITH NOVEL MECHANISM OF ACTION THAT SHOWS SUBUNIT SELECTIVITY
Authors: MEADOWS HJ KUMAR CS PRITCHETT DB BLACKBURN TP BENHAM CD
Citation: Hj. Meadows et al., SB-205384 - A GABA(A) RECEPTOR MODULATOR WITH NOVEL MECHANISM OF ACTION THAT SHOWS SUBUNIT SELECTIVITY, British Journal of Pharmacology, 123(6), 1998, pp. 1253-1259
EVIDENCE FOR EXPRESSION OF THE 5-HYDROXYTRYPTAMINE-2B RECEPTOR PROTEIN IN THE RAT CENTRAL-NERVOUS-SYSTEM
Authors: DUXON MS FLANIGAN TP REAVLEY AC BAXTER GS BLACKBURN TP FONE KCF
Citation: Ms. Duxon et al., EVIDENCE FOR EXPRESSION OF THE 5-HYDROXYTRYPTAMINE-2B RECEPTOR PROTEIN IN THE RAT CENTRAL-NERVOUS-SYSTEM, Neuroscience, 76(2), 1997, pp. 323-329
ACTIVATION OF 5-HT2B RECEPTORS IN THE MEDIAL AMYGDALA CAUSES ANXIOLYSIS IN THE SOCIAL-INTERACTION TEST IN THE RAT
Authors: DUXON MS KENNETT GA LIGHTOWLER S BLACKBURN TP FONE KCF
Citation: Ms. Duxon et al., ACTIVATION OF 5-HT2B RECEPTORS IN THE MEDIAL AMYGDALA CAUSES ANXIOLYSIS IN THE SOCIAL-INTERACTION TEST IN THE RAT, Neuropharmacology, 36(4-5), 1997, pp. 601-608
SB-242084, A SELECTIVE AND BRAIN PENETRANT 5-HT2C RECEPTOR ANTAGONIST
Authors: KENNETT GA WOOD MD BRIGHT F TRAIL B RILEY G HOLLAND V AVENELL KY STEAN T UPTON N BROMIDGE S FORBES IT BROWN AM MIDDLEMISS DN BLACKBURN TP
Citation: Ga. Kennett et al., SB-242084, A SELECTIVE AND BRAIN PENETRANT 5-HT2C RECEPTOR ANTAGONIST, Neuropharmacology, 36(4-5), 1997, pp. 609-620
ANXIOLYTIC-LIKE ACTIONS OF THE SELECTIVE 5-HT4 RECEPTOR ANTAGONISTS SB-204070A AND SB-207266A IN RATS
Authors: KENNETT GA BRIGHT F TRAIL B BLACKBURN TP SANGER GJ
Citation: Ga. Kennett et al., ANXIOLYTIC-LIKE ACTIONS OF THE SELECTIVE 5-HT4 RECEPTOR ANTAGONISTS SB-204070A AND SB-207266A IN RATS, Neuropharmacology, 36(4-5), 1997, pp. 707-712
BW 723C86, A 5-HT2B RECEPTOR AGONIST, CAUSES HYPERPHAGIA AND REDUCED GROOMING IN RATS
Authors: KENNETT GA AINSWORTH K TRAIL B BLACKBURN TP
Citation: Ga. Kennett et al., BW 723C86, A 5-HT2B RECEPTOR AGONIST, CAUSES HYPERPHAGIA AND REDUCED GROOMING IN RATS, Neuropharmacology, 36(2), 1997, pp. 233-239
ETHYL-3-PYRIDYL)OXY]-5-PYRIDYL]CARBAMOYL]-INDOLINE (SB-242084) - THE FIRST SELECTIVE AND BRAIN PENETRANT 5-HT2C RECEPTOR ANTAGONIST
Authors: BROMIDGE SM DUCKWORTH M FORBES IT HAM P KING FD THEWLIS KM BLANEY FE NAYLOR CB BLACKBURN TP KENNETT GA WOOD MD CLARKE SE
Citation: Sm. Bromidge et al., ETHYL-3-PYRIDYL)OXY]-5-PYRIDYL]CARBAMOYL]-INDOLINE (SB-242084) - THE FIRST SELECTIVE AND BRAIN PENETRANT 5-HT2C RECEPTOR ANTAGONIST, Journal of medicinal chemistry, 40(22), 1997, pp. 3494-3496
PROFILE OF SB-204269, A MECHANISTICALLY NOVEL ANTICONVULSANT DRUG, INRAT MODELS OF FOCAL AND GENERALIZED EPILEPTIC SEIZURES
Authors: UPTON N BLACKBURN TP CAMPBELL CA COOPER D EVANS ML HERDON HJ KING PD RAY AM STEAN TO CHAN WN EVANS JM THOMPSON M
Citation: N. Upton et al., PROFILE OF SB-204269, A MECHANISTICALLY NOVEL ANTICONVULSANT DRUG, INRAT MODELS OF FOCAL AND GENERALIZED EPILEPTIC SEIZURES, British Journal of Pharmacology, 121(8), 1997, pp. 1679-1686
EFFECTS OF SB-204070A AND SB-207266A, SELECTIVE 5-HT4 RECEPTOR ANTAGONISTS, IN 3 RAT MODELS OF ANXIETY
Authors: KENNETT GA BRIGHT F TRAIL B BLACKBURN TP SANGER GJ
Citation: Ga. Kennett et al., EFFECTS OF SB-204070A AND SB-207266A, SELECTIVE 5-HT4 RECEPTOR ANTAGONISTS, IN 3 RAT MODELS OF ANXIETY, British Journal of Pharmacology, 120, 1997, pp. 138-138
EFFECTS OF CLOZAPINE AND MDL-100,907 IN THE RAT GELLER-SEIFTER MODEL OF ANXIETY
Authors: BRIGHT F TRAIL B BLACKBURN TP KENNETT GA
Citation: F. Bright et al., EFFECTS OF CLOZAPINE AND MDL-100,907 IN THE RAT GELLER-SEIFTER MODEL OF ANXIETY, British Journal of Pharmacology, 120, 1997, pp. 244-244
EFFECT OF PAROXETINE AND MIANSERIN ON AMPHETAMINE-INDUCED HYPERLOCOMOTION
Authors: LIGHTOWLER S BRIGHT F STEVENS NC DEBIASI V BLACKBURN TP KENNETT GA
Citation: S. Lightowler et al., EFFECT OF PAROXETINE AND MIANSERIN ON AMPHETAMINE-INDUCED HYPERLOCOMOTION, British Journal of Pharmacology, 120, 1997, pp. 254-254
SYNTHESIS, BIOLOGICAL-ACTIVITY, AND MOLECULAR MODELING STUDIES OF SELECTIVE 5-HT2C 2B RECEPTOR ANTAGONISTS/
Authors: FORBES IT DABBS S DUCKWORTH DM HAM P JONES GE KING FD SAUNDERS DV BLANEY FE NAYLOR CB BAXTER GS BLACKBURN TP KENNETT GA WOOD MD
Citation: It. Forbes et al., SYNTHESIS, BIOLOGICAL-ACTIVITY, AND MOLECULAR MODELING STUDIES OF SELECTIVE 5-HT2C 2B RECEPTOR ANTAGONISTS/, Journal of medicinal chemistry, 39(25), 1996, pp. 4966-4977
CHARACTERIZATION OF A HUMAN 5-HYDROXYTRYPTAMINE(3) RECEPTOR-TYPE-A (H5-HT(3)R-A(S)) SUBUNIT STABLY EXPRESSED IN HEK-293 CELLS
Authors: HOPE AG PETERS JA BROWN AM LAMBERT JJ BLACKBURN TP
Citation: Ag. Hope et al., CHARACTERIZATION OF A HUMAN 5-HYDROXYTRYPTAMINE(3) RECEPTOR-TYPE-A (H5-HT(3)R-A(S)) SUBUNIT STABLY EXPRESSED IN HEK-293 CELLS, British Journal of Pharmacology, 118(5), 1996, pp. 1237-1245
THE 5HT(2C 2B) RECEPTOR ANTAGONIST, SB-206553, HAS ANXIOLYTIC-LIKE PROPERTIES IN 2 RAT MODELS/
Authors: KENNETT GA BRIGHT F DARCY S BLACKBURN TP
Citation: Ga. Kennett et al., THE 5HT(2C 2B) RECEPTOR ANTAGONIST, SB-206553, HAS ANXIOLYTIC-LIKE PROPERTIES IN 2 RAT MODELS/, British Journal of Pharmacology, 117, 1996, pp. 16-16
THE NOVEL 5-HT2C 2B RECEPTOR ANTAGONIST SB206553 IS A POTENT AND SURMOUNTABLE ANTAGONIST AT CLONED HUMAN RECEPTORS/
Authors: GAGER TL HOLLAND V THOMAS DR BLACKBURN TP
Citation: Tl. Gager et al., THE NOVEL 5-HT2C 2B RECEPTOR ANTAGONIST SB206553 IS A POTENT AND SURMOUNTABLE ANTAGONIST AT CLONED HUMAN RECEPTORS/, British Journal of Pharmacology, 117, 1996, pp. 133-133
IS BW 723C86-INDUCED HYPERPHAGIA AN IN-VIVO MODEL OF RAT CENTRAL 5-HT2B RECEPTOR FUNCTION
Authors: AINSWORTH K TRAIL B BLACKBURN TP BAXTER GS KENNETT GA
Citation: K. Ainsworth et al., IS BW 723C86-INDUCED HYPERPHAGIA AN IN-VIVO MODEL OF RAT CENTRAL 5-HT2B RECEPTOR FUNCTION, British Journal of Pharmacology, 117, 1996, pp. 178-178
EFFECT OF THE SELECTIVE 5-HT2B 2C RECEPTOR ANTAGONIST, SB-206553, ON MCPP-INDUCED AND ENVIRONMENTAL STRESS-INDUCED INCREASE IN PLASMA ADRENOCORTICOTROPIC HORMONE IN RATS/
Authors: WARD JL LIGHTOWLER S KENNETT GA BLACKBURN TP
Citation: Jl. Ward et al., EFFECT OF THE SELECTIVE 5-HT2B 2C RECEPTOR ANTAGONIST, SB-206553, ON MCPP-INDUCED AND ENVIRONMENTAL STRESS-INDUCED INCREASE IN PLASMA ADRENOCORTICOTROPIC HORMONE IN RATS/, British Journal of Pharmacology, 117, 1996, pp. 180-180
EFFECTS OF THE 5-HT2B RECEPTOR AGONIST, BW-723C86, ON 3 RAT MODELS OFANXIETY
Authors: KENNETT GA BRIGHT F TRAIL B BAXTER GS BLACKBURN TP
Citation: Ga. Kennett et al., EFFECTS OF THE 5-HT2B RECEPTOR AGONIST, BW-723C86, ON 3 RAT MODELS OFANXIETY, British Journal of Pharmacology, 117(7), 1996, pp. 1443-1448
IN-VITRO AND IN-VIVO PROFILE OF SB-206553, A POTENT 5-HT2C 5-HT2B RECEPTOR ANTAGONIST WITH ANXIOLYTIC-LIKE PROPERTIES/
Authors: KENNETT GA WOOD MD BRIGHT F CILIA J PIPER DC GAGER T THOMAS D BAXTER GS FORBES IT HAM P BLACKBURN TP
Citation: Ga. Kennett et al., IN-VITRO AND IN-VIVO PROFILE OF SB-206553, A POTENT 5-HT2C 5-HT2B RECEPTOR ANTAGONIST WITH ANXIOLYTIC-LIKE PROPERTIES/, British Journal of Pharmacology, 117(3), 1996, pp. 427-434
EFFECT OF SB 200646A, A 5-HT2C 5-HT2B RECEPTOR ANTAGONIST, IN 2 CONFLICT MODELS OF ANXIETY
Authors: KENNETT GA BAILEY F PIPER DC BLACKBURN TP
Citation: Ga. Kennett et al., EFFECT OF SB 200646A, A 5-HT2C 5-HT2B RECEPTOR ANTAGONIST, IN 2 CONFLICT MODELS OF ANXIETY, Psychopharmacology, 118(2), 1995, pp. 178-182
ISOSTERIC REPLACEMENT OF THE INDOLE NUCLEUS BY BENZOTHIOPHENE IN A SERIES OF PYRIDO[2,3-B]INDOLES WITH POTENTIAL ANXIOLYTIC ACTIVITY
Authors: BLACKBURN TP DAVIES DT FORBES IT HAYWARD CJ JOHNSON CN MARTIN RT PIPER DC THOMAS DR THOMPSON M UPTON N WARD RW
Citation: Tp. Blackburn et al., ISOSTERIC REPLACEMENT OF THE INDOLE NUCLEUS BY BENZOTHIOPHENE IN A SERIES OF PYRIDO[2,3-B]INDOLES WITH POTENTIAL ANXIOLYTIC ACTIVITY, Bioorganic & medicinal chemistry letters, 5(22), 1995, pp. 2589-2592
THE SYNTHESIS OF PYRAZOLO[4,3-C]-ARYL[E]FUSED AND IMIDAZO[4,5-C]-ARYL[E]FUSED PYRIDINES AS STRUCTURAL ANALOGS OF 4-AMINONICOTINOATES
Authors: BENHAM CD BLACKBURN TP JOHNS A KOTECHA NR MARTIN RT THOMAS DR THOMPSON M WARD RW
Citation: Cd. Benham et al., THE SYNTHESIS OF PYRAZOLO[4,3-C]-ARYL[E]FUSED AND IMIDAZO[4,5-C]-ARYL[E]FUSED PYRIDINES AS STRUCTURAL ANALOGS OF 4-AMINONICOTINOATES, Bioorganic & medicinal chemistry letters, 5(21), 1995, pp. 2455-2460
STEREOCHEMICAL DIFFERENTIATION OF ANTICONVULSANT AND ANTIHYPERTENSIVEEFFECTS IN 4-(FLUOROBENZOYLAMINO)BENZOPYRANS
Authors: BLACKBURN TP BUCKINGHAM RE CHAN WN EVANS JM HADLEY MS THOMPSON M UPTON N STEAN TO STEMP G VONG AK
Citation: Tp. Blackburn et al., STEREOCHEMICAL DIFFERENTIATION OF ANTICONVULSANT AND ANTIHYPERTENSIVEEFFECTS IN 4-(FLUOROBENZOYLAMINO)BENZOPYRANS, Bioorganic & medicinal chemistry letters, 5(11), 1995, pp. 1163-1166
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