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Results: 1-25 | 26-31
Results: 1-25/31
IN-VIVO SELECTION OF RETROVIRALLY TRANSDUCED HEMATOPOIETIC STEM-CELLS
Authors: ALLAY JA PERSONS DA GALIPEAU J RIBERDY JM ASHMUN RA BLAKLEY RL SORRENTINO BP
Citation: Ja. Allay et al., IN-VIVO SELECTION OF RETROVIRALLY TRANSDUCED HEMATOPOIETIC STEM-CELLS, Nature medicine, 4(10), 1998, pp. 1136-1143
IN-VITRO MUTATIONS IN DIHYDROFOLATE-REDUCTASE THAT CONFER RESISTANCE TO METHOTREXATE - POTENTIAL FOR CLINICAL-APPLICATION
Authors: BLAKLEY RL SORRENTINO BP
Citation: Rl. Blakley et Bp. Sorrentino, IN-VITRO MUTATIONS IN DIHYDROFOLATE-REDUCTASE THAT CONFER RESISTANCE TO METHOTREXATE - POTENTIAL FOR CLINICAL-APPLICATION, Human mutation, 11(4), 1998, pp. 259-263
PROTECTION OF CCRF-CEM HUMAN LYMPHOID-CELLS FROM ANTIFOLATES BY RETROVIRAL GENE-TRANSFER OF VARIANTS OF MURINE DIHYDROFOLATE-REDUCTASE
Authors: MAREYA SM SORRENTINO BP BLAKLEY RL
Citation: Sm. Mareya et al., PROTECTION OF CCRF-CEM HUMAN LYMPHOID-CELLS FROM ANTIFOLATES BY RETROVIRAL GENE-TRANSFER OF VARIANTS OF MURINE DIHYDROFOLATE-REDUCTASE, Cancer gene therapy, 5(4), 1998, pp. 225-235
COMPARISON OF TERNARY CRYSTAL COMPLEXES OF F31 VARIANTS OF HUMAN DIHYDROFOLATE-REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMIDINE
Authors: CODY V GALITSKY N LUFT JR PANGBORN W BLAKLEY RL GANGJEE A
Citation: V. Cody et al., COMPARISON OF TERNARY CRYSTAL COMPLEXES OF F31 VARIANTS OF HUMAN DIHYDROFOLATE-REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMIDINE, Anti-cancer drug design, 13(4), 1998, pp. 307-315
COMPARISON OF THE PROTECTION OF CELLS FROM ANTIFOLATES BY TRANSDUCED HUMAN DIHYDROFOLATE-REDUCTASE MUTANTS
Authors: PATEL M SLEEP SEH LEWIS WS SPENCER HT MAREYA SM SORRENTINO BP BLAKLEY RL
Citation: M. Patel et al., COMPARISON OF THE PROTECTION OF CELLS FROM ANTIFOLATES BY TRANSDUCED HUMAN DIHYDROFOLATE-REDUCTASE MUTANTS, Human gene therapy, 8(17), 1997, pp. 2069-2077
A BICISTRONIC RETROVIRAL VECTOR FOR PROTECTING HEMATOPOIETIC-CELLS AGAINST ANTIFOLATES AND P-GLYCOPROTEIN EFFLUXED DRUGS
Authors: GALIPEAU J BENAIM E SPENCER HT BLAKLEY RL SORRENTINO BP
Citation: J. Galipeau et al., A BICISTRONIC RETROVIRAL VECTOR FOR PROTECTING HEMATOPOIETIC-CELLS AGAINST ANTIFOLATES AND P-GLYCOPROTEIN EFFLUXED DRUGS, Human gene therapy, 8(15), 1997, pp. 1773-1783
CODING REGION-SPECIFIC DESTABILIZATION OF MESSENGER-RNA TRANSCRIPTS ATTENUATES EXPRESSION FROM RETROVIRAL VECTORS CONTAINING CLASS-1 ALDEHYDE DEHYDROGENASE CDNA
Authors: BUNTING KD WEBB M GIORGIANNI F GALIPEAU J BLAKLEY RL TOWNSEND AJ SORRENTINO BP
Citation: Kd. Bunting et al., CODING REGION-SPECIFIC DESTABILIZATION OF MESSENGER-RNA TRANSCRIPTS ATTENUATES EXPRESSION FROM RETROVIRAL VECTORS CONTAINING CLASS-1 ALDEHYDE DEHYDROGENASE CDNA, Human gene therapy, 8(13), 1997, pp. 1531-1543
COMPARISON OF TERNARY COMPLEXES OF PNEUMOCYSTIS-CARINII AND WILD-TYPEHUMAN DIHYDROFOLATE-REDUCTASE WITH COENZYME NADPH AND A NOVEL CLASSICAL ANTITUMOR FURO[2,3-D]PYRIMIDINE ANTIFOLATE
Authors: CODY V GALITSKY N LUFT JR PANGBORN W GANGJEE A DEVRAJ R QUEENER SF BLAKLEY RL
Citation: V. Cody et al., COMPARISON OF TERNARY COMPLEXES OF PNEUMOCYSTIS-CARINII AND WILD-TYPEHUMAN DIHYDROFOLATE-REDUCTASE WITH COENZYME NADPH AND A NOVEL CLASSICAL ANTITUMOR FURO[2,3-D]PYRIMIDINE ANTIFOLATE, Acta crystallographica. Section D, Biological crystallography, 53, 1997, pp. 638-649
SENSITIZATION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS TO TRIMETREXATE USING NUCLEOSIDE TRANSPORT INHIBITORS
Authors: ALLAY JA SPENCER HT WILKINSON SL BELT JA BLAKLEY RL SORRENTINO BP
Citation: Ja. Allay et al., SENSITIZATION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS TO TRIMETREXATE USING NUCLEOSIDE TRANSPORT INHIBITORS, Blood, 90(9), 1997, pp. 3546-3554
IN-VIVO SELECTION OF DHFR-MODIFIED HEMATOPOIETIC-CELLS FOLLOWING TRIMETREXATE AND NBMPR-P TREATMENT
Authors: ALLAY JA GALIPEAU J PERSONS DA ASHMUN RA BLAKLEY RL SORRENTINO BP
Citation: Ja. Allay et al., IN-VIVO SELECTION OF DHFR-MODIFIED HEMATOPOIETIC-CELLS FOLLOWING TRIMETREXATE AND NBMPR-P TREATMENT, Blood, 90(10), 1997, pp. 1064-1064
THE PROPORTION OF TRANSDUCED HEMATOPOIETIC-CELLS REQUIRED FOR PROTECTION FROM ANTIFOLATE-INDUCED MYELOSUPPRESSION
Authors: ALLAY JA PERSONS DA GALIPEAU J BLAKLEY RL SORRENTINO BP
Citation: Ja. Allay et al., THE PROPORTION OF TRANSDUCED HEMATOPOIETIC-CELLS REQUIRED FOR PROTECTION FROM ANTIFOLATE-INDUCED MYELOSUPPRESSION, Blood, 90(10), 1997, pp. 1065-1065
COMPARISON OF 2 INDEPENDENT CRYSTAL-STRUCTURES OF HUMAN DIHYDROFOLATE-REDUCTASE TERNARY COMPLEXES REDUCED WITH NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE AND THE VERY TIGHT-BINDING INHIBITOR PT523
Authors: CODY V GALITSKY N LUFT JR PANGBORN W ROSOWSKY A BLAKLEY RL
Citation: V. Cody et al., COMPARISON OF 2 INDEPENDENT CRYSTAL-STRUCTURES OF HUMAN DIHYDROFOLATE-REDUCTASE TERNARY COMPLEXES REDUCED WITH NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE AND THE VERY TIGHT-BINDING INHIBITOR PT523, Biochemistry, 36(45), 1997, pp. 13897-13903
MUTATIONS IN THE GENE FOR HUMAN DIHYDROFOLATE-REDUCTASE - AN UNLIKELYCAUSE OF CLINICAL RELAPSE IN PEDIATRIC LEUKEMIA AFTER THERAPY WITH METHOTREXATE
Authors: SPENCER HT SORRENTINO BP PUI CH CHUNDURU SK SLEEP SEH BLAKLEY RL
Citation: Ht. Spencer et al., MUTATIONS IN THE GENE FOR HUMAN DIHYDROFOLATE-REDUCTASE - AN UNLIKELYCAUSE OF CLINICAL RELAPSE IN PEDIATRIC LEUKEMIA AFTER THERAPY WITH METHOTREXATE, Leukemia, 10(3), 1996, pp. 439-446
PROTECTION OF HEMATOPOIETIC-CELLS FROM ANTIFOLATE TOXICITY BY A NOVELVARIANT OF HUMAN DIHYDROFOLATE-REDUCTASE
Authors: SORRENTINO BP SPENCER HT BLAKLEY RL ALLAY JA
Citation: Bp. Sorrentino et al., PROTECTION OF HEMATOPOIETIC-CELLS FROM ANTIFOLATE TOXICITY BY A NOVELVARIANT OF HUMAN DIHYDROFOLATE-REDUCTASE, Experimental hematology, 24(9), 1996, pp. 730-730
IN-VIVO SELECTION OF DHFR-MODIFIED MURINE HEMATOPOIETIC PROGENITORS BY COMBINED TREATMENT WITH TRIMETREXATE AND THYMIDINE TRANSPORT INHIBITORS
Authors: ALLAY JA SPENCER HT WILKINSON SL BELL JA BLAKLEY RL SORRENTINO BP
Citation: Ja. Allay et al., IN-VIVO SELECTION OF DHFR-MODIFIED MURINE HEMATOPOIETIC PROGENITORS BY COMBINED TREATMENT WITH TRIMETREXATE AND THYMIDINE TRANSPORT INHIBITORS, Blood, 88(10), 1996, pp. 2568-2568
A BICISTRONIC RETROVIRAL VECTOR FOR PROTECTING HEMATOPOIETIC-CELLS AGAINST ANTI-FOLATES AND MDR1-EFFLUXED DRUGS
Authors: GALIPEAU J BENAIM E SPENCER HT BLAKLEY RL SORRENTINO BP
Citation: J. Galipeau et al., A BICISTRONIC RETROVIRAL VECTOR FOR PROTECTING HEMATOPOIETIC-CELLS AGAINST ANTI-FOLATES AND MDR1-EFFLUXED DRUGS, Blood, 88(10), 1996, pp. 2569-2569
A GENE-TRANSFER STRATEGY FOR MAKING BONE-MARROW CELLS RESISTANT TO TRIMETREXATE
Authors: SPENCER HT SLEEP SEH REHG JE BLAKLEY RL SORRENTINO BP
Citation: Ht. Spencer et al., A GENE-TRANSFER STRATEGY FOR MAKING BONE-MARROW CELLS RESISTANT TO TRIMETREXATE, Blood, 87(6), 1996, pp. 2579-2587
GENERATION OF ANTIFOLATE RESISTANCE BY RETROVIRAL VECTORS ENCODING VARIANTS OF MOUSE DIHYDROFOLATE-REDUCTASE
Authors: MAREYA SM BLAKLEY RL
Citation: Sm. Mareya et Rl. Blakley, GENERATION OF ANTIFOLATE RESISTANCE BY RETROVIRAL VECTORS ENCODING VARIANTS OF MOUSE DIHYDROFOLATE-REDUCTASE, The FASEB journal, 9(6), 1995, pp. 1316-1316
METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE-REDUCTASE WITHSUBSTITUTIONS OF LEUCINE-22 - KINETICS, CRYSTALLOGRAPHY, AND POTENTIAL AS SELECTABLE MARKERS
Authors: LEWIS WS CODY V GALITSKY N LUFT JR PANGBORN W CHUNDURU SK SPENCER HT APPLEMAN JR BLAKLEY RL
Citation: Ws. Lewis et al., METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE-REDUCTASE WITHSUBSTITUTIONS OF LEUCINE-22 - KINETICS, CRYSTALLOGRAPHY, AND POTENTIAL AS SELECTABLE MARKERS, The Journal of biological chemistry, 270(10), 1995, pp. 5057-5064
PROTECTION OF MICE FROM TRIMETREXATE-INDUCED MYELOSUPPRESSION BY TRANSFER OF A TYR22 DIHYDROFOLATE-REDUCTASE GENE
Authors: SPENCER HT BLAKLEY RL SORRENTINO BP
Citation: Ht. Spencer et al., PROTECTION OF MICE FROM TRIMETREXATE-INDUCED MYELOSUPPRESSION BY TRANSFER OF A TYR22 DIHYDROFOLATE-REDUCTASE GENE, Blood, 86(10), 1995, pp. 1847-1847
USE OF STROMA-SUPPORTED CULTURES OF LEUKEMIC-CELLS TO ASSESS ANTILEUKEMIC DRUGS .2. POTENT CYTOTOXICITY OF 2-CHLORO-DEOXYADENOSINE IN ACUTELYMPHOBLASTIC-LEUKEMIA
Authors: KUMAGAI M MANABE A COUSTANSMITH E BLAKLEY RL BECK WT SANTANA VM BEHM FG RAIMONDI SC CAMPANA D
Citation: M. Kumagai et al., USE OF STROMA-SUPPORTED CULTURES OF LEUKEMIC-CELLS TO ASSESS ANTILEUKEMIC DRUGS .2. POTENT CYTOTOXICITY OF 2-CHLORO-DEOXYADENOSINE IN ACUTELYMPHOBLASTIC-LEUKEMIA, Leukemia, 8(7), 1994, pp. 1116-1123
METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE-REDUCTASE - EFFECTS OF PHE31 SUBSTITUTIONS
Authors: CHUNDURU SK CODY V LUFT JR PANGBORN W APPLEMAN JR BLAKLEY RL
Citation: Sk. Chunduru et al., METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE-REDUCTASE - EFFECTS OF PHE31 SUBSTITUTIONS, The Journal of biological chemistry, 269(13), 1994, pp. 9547-9555
PHARMACOKINETICS OF CLADRIBINE (2-CHLORODEOXYADENOSINE) IN CHILDREN WITH ACUTE-LEUKEMIA
Authors: KEARNS CM BLAKLEY RL SANTANA VM CROM WR
Citation: Cm. Kearns et al., PHARMACOKINETICS OF CLADRIBINE (2-CHLORODEOXYADENOSINE) IN CHILDREN WITH ACUTE-LEUKEMIA, Cancer research, 54(5), 1994, pp. 1235-1239
COMPLETE HEMATOLOGIC REMISSIONS INDUCED BY 2-CHLORODEOXYADENOSINE IN CHILDREN WITH NEWLY-DIAGNOSED ACUTE MYELOID-LEUKEMIA
Authors: SANTANA VM HURWITZ CA BLAKLEY RL CROM WR LUO XL ROBERTS WM RIBEIRO R MAHMOUD H KRANCE RA
Citation: Vm. Santana et al., COMPLETE HEMATOLOGIC REMISSIONS INDUCED BY 2-CHLORODEOXYADENOSINE IN CHILDREN WITH NEWLY-DIAGNOSED ACUTE MYELOID-LEUKEMIA, Blood, 84(4), 1994, pp. 1237-1242
GENERATION OF METHOTREXATE-RESISTANT HEMATOPOIETIC PROGENITOR CELLS BY RETROVIRAL TRANSFER OF CDNAS ENCODING NOVEL VARIANTS OF HUMAN DIHYDROFOLATE-REDUCTASE
Authors: SPENCER HT LEWIS WS CHUNDURU SK BLAKLEY RL SORRENTINO BP
Citation: Ht. Spencer et al., GENERATION OF METHOTREXATE-RESISTANT HEMATOPOIETIC PROGENITOR CELLS BY RETROVIRAL TRANSFER OF CDNAS ENCODING NOVEL VARIANTS OF HUMAN DIHYDROFOLATE-REDUCTASE, Blood, 84(10), 1994, pp. 10000401-10000401
Risultati: 1-25 | 26-31