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Results: 1-23 |
Results: 23
A SYNTHESIS OF MYCALAMIDE-B
Authors: KOCIENSKI PJ NARQUIZIAN R RAUBO P SMITH C BOYLE FT
Citation: Pj. Kocienski et al., A SYNTHESIS OF MYCALAMIDE-B, Synlett, (8), 1998, pp. 869
CANCER-THERAPY - A MOVE TO THE MOLECULAR-LEVEL
Authors: BOYLE FT COSTELLO GF
Citation: Ft. Boyle et Gf. Costello, CANCER-THERAPY - A MOVE TO THE MOLECULAR-LEVEL, Chemical Society reviews, 27(4), 1998, pp. 251-261
THE RENAL EFFECTS OF THE WATER-SOLUBLE, NON-FOLYLPOLYGLUTAMATE SYNTHETASE DEPENDENT THYMIDYLATE SYNTHASE INHIBITOR ZD9331 IN MICE
Authors: WALTON MI MITCHELL F AHERNE GW MEDLOW CJ BOYLE FT JACKSON AL
Citation: Mi. Walton et al., THE RENAL EFFECTS OF THE WATER-SOLUBLE, NON-FOLYLPOLYGLUTAMATE SYNTHETASE DEPENDENT THYMIDYLATE SYNTHASE INHIBITOR ZD9331 IN MICE, British Journal of Cancer, 78(11), 1998, pp. 1457-1463
CELLULAR PHARMACOLOGY AND IN-VIVO ACTIVITY OF A NEW ANTICANCER AGENT,ZD9331 - A WATER-SOLUBLE, NONPOLYGLUTAMATABLE, QUINAZOLINE-BASED INHIBITOR OF THYMIDYLATE SYNTHASE
Authors: JACKMAN AL KIMBELL R AHERNE GW BRUNTON L JANSEN G STEPHENS TC SMITH MN WARDLEWORTH JM BOYLE FT
Citation: Al. Jackman et al., CELLULAR PHARMACOLOGY AND IN-VIVO ACTIVITY OF A NEW ANTICANCER AGENT,ZD9331 - A WATER-SOLUBLE, NONPOLYGLUTAMATABLE, QUINAZOLINE-BASED INHIBITOR OF THYMIDYLATE SYNTHASE, Clinical cancer research, 3(6), 1997, pp. 911-921
APPLICATIONS OF THE SPIROANNULATION OF TETRALINS WITH ALKYNES - TOWARDS NEW ANTIESTROGENIC COMPOUNDS
Authors: BOYLE FT HARES O MATUSIAK ZS LI W WHITING DA
Citation: Ft. Boyle et al., APPLICATIONS OF THE SPIROANNULATION OF TETRALINS WITH ALKYNES - TOWARDS NEW ANTIESTROGENIC COMPOUNDS, Journal of the Chemical Society. Perkin transactions. I, (18), 1997, pp. 2707-2711
SYNTHESIS OF NOVEL QUINAZOLINE-BASED ANTIFOLATES WITH MODIFIED GLUTAMATE SIDE-CHAINS AS POTENTIAL INHIBITORS OF THYMIDYLATE SYNTHASE AND ANTITUMOR AGENTS
Authors: BAVETSIAS V BISSET GMF KIMBELL R BOYLE FT JACKMAN AL
Citation: V. Bavetsias et al., SYNTHESIS OF NOVEL QUINAZOLINE-BASED ANTIFOLATES WITH MODIFIED GLUTAMATE SIDE-CHAINS AS POTENTIAL INHIBITORS OF THYMIDYLATE SYNTHASE AND ANTITUMOR AGENTS, Tetrahedron, 53(39), 1997, pp. 13383-13396
FOLATE-BASED INHIBITORS OF THYMIDYLATE SYNTHASE - SYNTHESIS AND ANTITUMOR-ACTIVITY OF GAMMA-LINKED STERICALLY HINDERED DIPEPTIDE ANALOGS OF-DESAMINO-2-METHYL-N-10-PROPARGYL-5,8-DIDEAZAFOLIC ACID (ICI-198583)
Authors: BAVETSIAS V JACKMAN AL MARRIOTT JH KIMBELL R GIBSON W BOYLE FT BISSET GMF
Citation: V. Bavetsias et al., FOLATE-BASED INHIBITORS OF THYMIDYLATE SYNTHASE - SYNTHESIS AND ANTITUMOR-ACTIVITY OF GAMMA-LINKED STERICALLY HINDERED DIPEPTIDE ANALOGS OF-DESAMINO-2-METHYL-N-10-PROPARGYL-5,8-DIDEAZAFOLIC ACID (ICI-198583), Journal of medicinal chemistry, 40(10), 1997, pp. 1495-1510
CARBOXYLIC-ACID BIOISOSTERES OF GAMMA-LINKED DIPEPTIDE ANALOGS OF THEFOLATE-BASED THYMIDYLATE SYNTHASE (TS) INHIBITOR, -DESAMINO-2-METHYL-N-10-PROPARGYL-5,8-DIDEAZAFOLIC ACID (ICI-198583)
Authors: BAVETSIAS V JACKMAN AL KIMBELL R BOYLE FT BISSET GMF
Citation: V. Bavetsias et al., CARBOXYLIC-ACID BIOISOSTERES OF GAMMA-LINKED DIPEPTIDE ANALOGS OF THEFOLATE-BASED THYMIDYLATE SYNTHASE (TS) INHIBITOR, -DESAMINO-2-METHYL-N-10-PROPARGYL-5,8-DIDEAZAFOLIC ACID (ICI-198583), Bioorganic & medicinal chemistry letters, 6(6), 1996, pp. 631-636
SYNTHESIS OF 18-O-METHYL MYCALAMIDE-B
Authors: KOCIENSKI P RAUBO P DAVIS JK BOYLE FT DAVIES DE RICHTER A
Citation: P. Kocienski et al., SYNTHESIS OF 18-O-METHYL MYCALAMIDE-B, Journal of the Chemical Society. Perkin transactions. I, (15), 1996, pp. 1797-1808
PRODRUGS OF THYMIDYLATE SYNTHASE INHIBITORS - POTENTIAL FOR ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY (ADEPT)
Authors: SPRINGER CJ BAVETSIAS V JACKMAN AL BOYLE FT MARSHALL D PEDLEY RB BISSET GMF
Citation: Cj. Springer et al., PRODRUGS OF THYMIDYLATE SYNTHASE INHIBITORS - POTENTIAL FOR ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY (ADEPT), Anti-cancer drug design, 11(8), 1996, pp. 625-636
TOMUDEX(TM) (ZD1694) - FROM CONCEPT TO CARE, A PROGRAM IN RATIONAL DRUG DISCOVERY
Authors: JACKMAN AL BOYLE FT HARRAP KR
Citation: Al. Jackman et al., TOMUDEX(TM) (ZD1694) - FROM CONCEPT TO CARE, A PROGRAM IN RATIONAL DRUG DISCOVERY, Investigational new drugs, 14(3), 1996, pp. 305-316
NEW MUSTARD PRODRUGS FOR ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY - ALTERNATIVES TO THE AMIDE LINK
Authors: DOWELL RI SPRINGER CJ DAVIES DH HADLEY EM BURKE PJ BOYLE FT MELTON RG CONNORS TA BLAKEY DC MAUGER AB
Citation: Ri. Dowell et al., NEW MUSTARD PRODRUGS FOR ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY - ALTERNATIVES TO THE AMIDE LINK, Journal of medicinal chemistry, 39(5), 1996, pp. 1100-1105
QUINAZOLINE ANTIFOLATES THYMIDYLATE SYNTHASE INHIBITORS - LIPOPHILIC ANALOGS WITH MODIFICATION TO THE C2-METHYL SUBSTITUENT
Authors: HENNEQUIN LF BOYLE FT WARDLEWORTH JM MARSHAM PR KIMBELL R JACKMAN AL
Citation: Lf. Hennequin et al., QUINAZOLINE ANTIFOLATES THYMIDYLATE SYNTHASE INHIBITORS - LIPOPHILIC ANALOGS WITH MODIFICATION TO THE C2-METHYL SUBSTITUENT, Journal of medicinal chemistry, 39(3), 1996, pp. 695-704
QUINAZOLINE ANTIFOLATE THYMIDYLATE SYNTHASE INHIBITORS - GAMMA-LINKEDL-D, D-D, AND D-L DIPEPTIDE ANALOGS OF -DESAMINO-2-METHYL-N-10-PROPARGYL-5,8-DIDEAZAFOLIC ACID (ICI-198583)
Authors: BAVETSIAS V JACKMAN AL KIMBELL R GIBSON W BOYLE FT BISSET GMF
Citation: V. Bavetsias et al., QUINAZOLINE ANTIFOLATE THYMIDYLATE SYNTHASE INHIBITORS - GAMMA-LINKEDL-D, D-D, AND D-L DIPEPTIDE ANALOGS OF -DESAMINO-2-METHYL-N-10-PROPARGYL-5,8-DIDEAZAFOLIC ACID (ICI-198583), Journal of medicinal chemistry, 39(1), 1996, pp. 73-85
ZD1694 (TOMUDEX) - A NEW THYMIDYLATE SYNTHASE INHIBITOR WITH ACTIVITYIN COLORECTAL-CANCER
Authors: JACKMAN AL FARRUGIA DC GIBSON W KIMBELL R HARRAP KR STEPHENS TC AZAB M BOYLE FT
Citation: Al. Jackman et al., ZD1694 (TOMUDEX) - A NEW THYMIDYLATE SYNTHASE INHIBITOR WITH ACTIVITYIN COLORECTAL-CANCER, European journal of cancer, 31A(7-8), 1995, pp. 1277-1282
QUINAZOLINE THYMIDYLATE SYNTHASE INHIBITORS - METHODS FOR ASSESSING THE CONTRIBUTION OF POLYGLUTAMATION TO THEIR IN-VITRO ACTIVITY
Authors: JACKMAN AL KIMBELL R BROWN M BRUNTON L BOYLE FT
Citation: Al. Jackman et al., QUINAZOLINE THYMIDYLATE SYNTHASE INHIBITORS - METHODS FOR ASSESSING THE CONTRIBUTION OF POLYGLUTAMATION TO THEIR IN-VITRO ACTIVITY, Anti-cancer drug design, 10(7), 1995, pp. 555-572
QUINAZOLINE-BASED THYMIDYLATE SYNTHASE INHIBITORS - RELATIONSHIP BETWEEN STRUCTURAL MODIFICATIONS AND POLYGLUTAMATION
Authors: JACKMAN AL KIMBELL R BROWN M BRUNTON L BISSET GMF BAVETSIAS V MARSHAM P HUGHES LR BOYLE FT
Citation: Al. Jackman et al., QUINAZOLINE-BASED THYMIDYLATE SYNTHASE INHIBITORS - RELATIONSHIP BETWEEN STRUCTURAL MODIFICATIONS AND POLYGLUTAMATION, Anti-cancer drug design, 10(7), 1995, pp. 573-589
CARRIER-MEDIATED AND RECEPTOR-MEDIATED TRANSPORT OF FOLATE ANTAGONISTS TARGETING FOLATE-DEPENDENT ENZYMES - CORRELATES OF MOLECULAR-STRUCTURE AND BIOLOGICAL-ACTIVITY
Authors: WESTERHOF GR SCHORNAGEL JH KATHMANN I JACKMAN AL ROSOWSKY A FORSCH RA HYNES JB BOYLE FT PETERS GJ PINEDO HM JANSEN G
Citation: Gr. Westerhof et al., CARRIER-MEDIATED AND RECEPTOR-MEDIATED TRANSPORT OF FOLATE ANTAGONISTS TARGETING FOLATE-DEPENDENT ENZYMES - CORRELATES OF MOLECULAR-STRUCTURE AND BIOLOGICAL-ACTIVITY, Molecular pharmacology, 48(3), 1995, pp. 459-471
QUINAZOLINE ANTIFOLATE THYMIDYLATE SYNTHASE INHIBITORS - REPLACEMENT OF GLUTAMIC-ACID IN THE C2-METHYL SERIES
Authors: MARSHAM PR JACKMAN AL BARKER AJ BOYLE FT PEGG SJ WARDLEWORTH JM KIMBELL R OCONNOR BM CALVERT AH HUGHES LR
Citation: Pr. Marsham et al., QUINAZOLINE ANTIFOLATE THYMIDYLATE SYNTHASE INHIBITORS - REPLACEMENT OF GLUTAMIC-ACID IN THE C2-METHYL SERIES, Journal of medicinal chemistry, 38(6), 1995, pp. 994-1004
MECHANISMS OF ACQUIRED-RESISTANCE TO THE QUINAZOLINE THYMIDYLATE SYNTHASE INHIBITOR ZD1694 (TOMUDEX) IN ONE MOUSE AND 3 HUMAN CELL-LINES
Authors: JACKMAN AL KELLAND LR KIMBELL R BROWN M GIBSON W AHERNE GW HARDCASTLE A BOYLE FT
Citation: Al. Jackman et al., MECHANISMS OF ACQUIRED-RESISTANCE TO THE QUINAZOLINE THYMIDYLATE SYNTHASE INHIBITOR ZD1694 (TOMUDEX) IN ONE MOUSE AND 3 HUMAN CELL-LINES, British Journal of Cancer, 71(5), 1995, pp. 914-924
IBM, TALKING HEADS, AND OUR CLASSROOMS AND ELECTRONIC MAIL AND THE WRITING INSTRUCTOR - RESPONSE
Authors: BOYLE FT
Citation: Ft. Boyle, IBM, TALKING HEADS, AND OUR CLASSROOMS AND ELECTRONIC MAIL AND THE WRITING INSTRUCTOR - RESPONSE, College English, 56(7), 1994, pp. 847-848
IBM, TALKING HEADS, AND OUR CLASSROOMS
Authors: BOYLE FT
Citation: Ft. Boyle, IBM, TALKING HEADS, AND OUR CLASSROOMS, College English, 55(6), 1993, pp. 618-626
THE IN-VIVO METABOLIC STABILITY OF DIPEPTIDE ANALOGS OF THE QUINAZOLINE ANTIFOLATE, ICI-198583, IN MICE
Authors: JODRELL DI GIBSON W BISSET GMF BOYLE FT JUDSON IR JACKMAN AL
Citation: Di. Jodrell et al., THE IN-VIVO METABOLIC STABILITY OF DIPEPTIDE ANALOGS OF THE QUINAZOLINE ANTIFOLATE, ICI-198583, IN MICE, Biochemical pharmacology, 46(12), 1993, pp. 2229-2234
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