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Results: 1-25 | 26-33
Results: 1-25/33
Synaptically released zinc: Physiological functions and pathological effects
Authors: Frederickson, CJ Bush, AI
Citation: Cj. Frederickson et Ai. Bush, Synaptically released zinc: Physiological functions and pathological effects, BIOMETALS, 14(3-4), 2001, pp. 353-366
Therapeutic targets in the biology of Alzheimer's disease
Authors: Bush, AI
Citation: Ai. Bush, Therapeutic targets in the biology of Alzheimer's disease, CUR OPIN P, 14(4), 2001, pp. 341-348
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice
Authors: Cherny, RA Atwood, CS Xilinas, ME Gray, DN Jones, WD McLean, CA Barnham, KJ Volitakis, I Fraser, FW Kim, YS Huang, XD Goldstein, LE Moir, RD Lim, JT Beyreuther, K Zheng, H Tanzi, RE Masters, CL Bush, AI
Citation: Ra. Cherny et al., Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice, NEURON, 30(3), 2001, pp. 665-676
Redox-active iron mediates amyloid-beta toxicity
Authors: Rottkamp, CA Raina, AK Zhu, XW Gaier, E Bush, AI Atwood, CS Chevion, M Perry, G Smith, MA
Citation: Ca. Rottkamp et al., Redox-active iron mediates amyloid-beta toxicity, FREE RAD B, 30(4), 2001, pp. 447-450
Clioquinol's return: Cautions from Japan - Response
Authors: Bush, AI Masters, CL
Citation: Ai. Bush et Cl. Masters, Clioquinol's return: Cautions from Japan - Response, SCIENCE, 292(5525), 2001, pp. 2251-2252
Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways
Authors: White, AR Huang, XD Jobling, MF Barrow, CJ Beyreuther, K Masters, CL Bush, AI Cappai, R
Citation: Ar. White et al., Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways, J NEUROCHEM, 76(5), 2001, pp. 1509-1520
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits
Authors: Curtain, CC Ali, F Volitakis, I Cherny, RA Norton, RS Beyreuther, K Barrow, CJ Masters, CL Bush, AI Barnham, KJ
Citation: Cc. Curtain et al., Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits, J BIOL CHEM, 276(23), 2001, pp. 20466-20473
Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126
Authors: Jobling, MF Huang, XD Stewart, LR Barnham, KJ Curtain, C Volitakis, I Perugini, M White, AR Cherny, RA Masters, CL Barrow, CJ Collins, SJ Bush, AI Cappai, R
Citation: Mf. Jobling et al., Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126, BIOCHEM, 40(27), 2001, pp. 8073-8084
Neuroinflammatory responses in the Alzheimer's disease brain promote the oxidative post-translational modification of amyloid deposits
Authors: Atwood, CS Huang, XD Moir, RD Smith, MA Tanzi, RE Roher, AE Bush, AI Perry, G
Citation: Cs. Atwood et al., Neuroinflammatory responses in the Alzheimer's disease brain promote the oxidative post-translational modification of amyloid deposits, ALZHEIMER'S DISEASE, 2001, pp. 341-361
Parallels between the redox properties and toxicity of A beta in Alzheimer's disease and mutant Cu/Zn-SOD in familial amyotrophic lateral sclerosis
Authors: Bush, AI
Citation: Ai. Bush, Parallels between the redox properties and toxicity of A beta in Alzheimer's disease and mutant Cu/Zn-SOD in familial amyotrophic lateral sclerosis, ALZHEIMER'S DISEASE, 2001, pp. 393-406
Metals and neuroscience
Authors: Bush, AI
Citation: Ai. Bush, Metals and neuroscience, CURR OP C B, 4(2), 2000, pp. 184-191
Chelation and intercalation: Complementary properties in a compound for the treatment of Alzheimer's disease
Authors: Cherny, RA Barnham, KJ Lynch, T Volitakis, I Li, QX McLean, CA Multhaup, G Beyreuher, K Tanzi, RE Masters, CL Bush, AI
Citation: Ra. Cherny et al., Chelation and intercalation: Complementary properties in a compound for the treatment of Alzheimer's disease, J STRUCT B, 130(2-3), 2000, pp. 209-216
N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis
Authors: Andreassen, OA Dedeoglu, A Klivenyi, P Beal, MF Bush, AI
Citation: Oa. Andreassen et al., N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis, NEUROREPORT, 11(11), 2000, pp. 2491-2493
Oxidative processes in Alzheimer's disease: the role of A beta-metal interactions
Authors: Lynch, T Cherny, RA Bush, AI
Citation: T. Lynch et al., Oxidative processes in Alzheimer's disease: the role of A beta-metal interactions, EXP GERONT, 35(4), 2000, pp. 445-451
Copper catalyzed oxidation of alzheimer A beta
Authors: Atwood, CS Huang, XD Khatri, A Scarpa, RC Kim, YS Moir, RD Tanzi, RE Roher, AE Bush, AI
Citation: Cs. Atwood et al., Copper catalyzed oxidation of alzheimer A beta, CELL MOL B, 46(4), 2000, pp. 777-783
Alzheimer's disease, beta-amyloid protein and zinc
Authors: Huang, XD Cuajungco, MP Atwood, CS Moir, RD Tanzi, RE Bush, AI
Citation: Xd. Huang et al., Alzheimer's disease, beta-amyloid protein and zinc, J NUTR, 130(5), 2000, pp. 1488S-1492S
Characterization of copper interactions with Alzheimer amyloid beta peptides: Identification of an attomolar-affinity copper binding site on amyloid beta 1-42
Authors: Atwood, CS Scarpa, RC Huang, XD Moir, RD Jones, WD Fairlie, DP Tanzi, RE Bush, AI
Citation: Cs. Atwood et al., Characterization of copper interactions with Alzheimer amyloid beta peptides: Identification of an attomolar-affinity copper binding site on amyloid beta 1-42, J NEUROCHEM, 75(3), 2000, pp. 1219-1233
Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of A beta by zinc
Authors: Cuajungco, MP Goldstein, LE Nunomura, A Smith, MA Lim, JT Atwood, CS Huang, XD Farrag, YW Perry, G Bush, AI
Citation: Mp. Cuajungco et al., Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of A beta by zinc, J BIOL CHEM, 275(26), 2000, pp. 19439-19442
3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction
Authors: Goldstein, LE Leopold, MC Huang, XD Atwood, CS Saunders, AJ Hartshorn, M Lim, JT Faget, KY Muffat, JA Scarpa, RC Chylack, LT Bowden, EF Tanzi, RE Bush, AI
Citation: Le. Goldstein et al., 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction, BIOCHEM, 39(24), 2000, pp. 7266-7275
Anti-apoptotic action of Alzheimer A beta
Authors: Chan, CW Dharmarajan, A Atwood, CS Huang, XD Tanzi, RE Bush, AI Martins, RN
Citation: Cw. Chan et al., Anti-apoptotic action of Alzheimer A beta, ALZHEIM REP, 2(2), 1999, pp. 113-119
Soluble pool of A beta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
Authors: McLean, CA Cherny, RA Fraser, FW Fuller, SJ Smith, MJ Beyreuther, K Bush, AI Masters, CL
Citation: Ca. Mclean et al., Soluble pool of A beta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease, ANN NEUROL, 46(6), 1999, pp. 860-866
The Alzheimer's disease amyloid precursor protein modulates copper-inducedtoxicity and oxidative stress in primary neuronal cultures
Authors: White, AR Multhaup, G Maher, F Bellingham, S Camakaris, J Zheng, H Bush, AI Beyreuther, K Masters, CL Cappai, R
Citation: Ar. White et al., The Alzheimer's disease amyloid precursor protein modulates copper-inducedtoxicity and oxidative stress in primary neuronal cultures, J NEUROSC, 19(21), 1999, pp. 9170-9179
The possible origin of free radicals from amyloid beta peptides in Alzheimer's disease
Authors: Bush, AI Huang, XD Fairlie, DP
Citation: Ai. Bush et al., The possible origin of free radicals from amyloid beta peptides in Alzheimer's disease, NEUROBIOL A, 20(3), 1999, pp. 335-337
Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease
Authors: Atwood, CS Huang, XD Moir, RD Tanzi, RE Bush, AI
Citation: Cs. Atwood et al., Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease, METAL IONS, 36, 1999, pp. 309-364
Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice
Authors: Li, QX Maynard, C Cappai, R McLean, CA Cherny, RA Lynch, T Culvenor, JG Trevaskis, J Tanner, JE Bailey, KA Czech, C Bush, AI Beyreuther, K Masters, CL
Citation: Qx. Li et al., Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice, J NEUROCHEM, 72(6), 1999, pp. 2479-2487
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