Authors:
van Gelder, T
Klupp, J
Barten, MJ
Christians, U
Morris, RE
Citation: T. Van Gelder et al., Comparison of the effects of tacrolimus and cyclosporine on the pharmacokinetics of mycophenolic acid, THER DRUG M, 23(2), 2001, pp. 119-128
Authors:
van Gelder, T
Klupp, J
Sawamoto, T
Christians, U
Morris, RE
Citation: T. Van Gelder et al., ATP-binding cassette transporters and calcineurin inhibitors: Potential clinical implications, TRANSPLAN P, 33(3), 2001, pp. 2420-2421
Authors:
Jacobsen, W
Serkova, N
Hausen, B
Morris, RE
Benet, LZ
Christians, U
Citation: W. Jacobsen et al., Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD, TRANSPLAN P, 33(1-2), 2001, pp. 514-515
Authors:
Hausen, B
Klupp, J
Christians, U
Higgins, JP
Baumgartner, RE
Hook, LE
Friedrich, S
Celnicker, A
Morris, RE
Citation: B. Hausen et al., Coadministration of either cyclosporine or steroids with humanized monoclonal antibodies against CD80 and CD86 successfully prolong allograft survival after life supporting renal transplantation in cynomolgus monkeys, TRANSPLANT, 72(6), 2001, pp. 1128-1137
Authors:
Kuhn, B
Jacobsen, W
Christians, U
Benet, LZ
Kollman, PA
Citation: B. Kuhn et al., Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: Insights from docking, molecular dynamics, and quantum chemical calculations, J MED CHEM, 44(12), 2001, pp. 2027-2034
Authors:
Mancinelli, LM
Frassetto, L
Floren, LC
Dressler, D
Carrier, S
Bekersky, I
Benet, LZ
Christians, U
Citation: Lm. Mancinelli et al., The pharmacokinetics and metabolic disposition of tacrolimus: A comparisonacross ethnic groups, CLIN PHARM, 69(1), 2001, pp. 24-31
Authors:
Serkova, N
Jacobsen, W
Niemann, CU
Litt, L
Benet, LZ
Leibfritz, D
Christians, U
Citation: N. Serkova et al., Sirolimus, but not the structurally related RAD (everolimus), enhances thenegative effects of cyclosporine on mitochondrial metabolism in the rat brain, BR J PHARM, 133(6), 2001, pp. 875-885
Authors:
Christians, U
Jacobsen, W
Serkova, N
Benet, LZ
Vidal, C
Sewing, KF
Manns, MP
Kirchner, GI
Citation: U. Christians et al., Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants, J CHROMAT B, 748(1), 2000, pp. 41-53
Authors:
Jacobsen, W
Kuhn, B
Soldner, A
Kirchner, G
Sewing, KF
Kollman, PA
Benet, LZ
Christians, U
Citation: W. Jacobsen et al., Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin, DRUG META D, 28(11), 2000, pp. 1369-1378
Authors:
Braun, F
Christians, U
Laabs, S
Elias, K
Shipkova, M
Schutz, E
Ringe, B
Citation: F. Braun et al., An ex vivo model to study the intestinal biotransformation of immunosuppressive drugs, TRANSPLAN P, 32(7), 2000, pp. 1999-1999
Authors:
Ikonen, TS
Gummert, JF
Hayase, M
Honda, Y
Hausen, B
Christians, U
Berry, GJ
Yock, PG
Morris, RE
Citation: Ts. Ikonen et al., Sirolimus (rapamycin) halts and reverses progression of allograft vasculardisease in non-human primates, TRANSPLANT, 70(6), 2000, pp. 969-975
Authors:
Hausen, B
Gummert, J
Berry, GJ
Christians, U
Serkova, N
Ikonen, T
Hook, L
Legay, F
Schuler, W
Schreier, MH
Morris, RE
Citation: B. Hausen et al., Prevention of acute allograft rejection in nonhuman primate lung transplant recipients - Induction with chimeric anti-interleukin-2 receptor monoclonal antibody improves the tolerability and potentiates the immunosuppressiveactivity of a regimen using low doses of both microemulsion cyclosporine and 40-O-(2-hydroxyethyl)-rapamycin, TRANSPLANT, 69(4), 2000, pp. 488-496
Authors:
Hausen, B
Ikonen, T
Briffa, N
Berry, GJ
Christians, U
Robbins, RC
Hook, L
Serkova, N
Benet, LZ
Schuler, W
Morris, RE
Citation: B. Hausen et al., Combined immunosuppression with cyclosporine (Neoral) and SDZ RAD in non-human primate lung transplantation: Systematic pharmacokinetic-based trials to improve efficacy and tolerability, TRANSPLANT, 69(1), 2000, pp. 76-86
Authors:
Serkova, N
Hausen, B
Berry, GJ
Jacobsen, W
Benet, LZ
Morris, RE
Christians, U
Citation: N. Serkova et al., Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: Interaction with cyclosporine, J PHARM EXP, 294(1), 2000, pp. 323-332
Authors:
Soldner, A
Benet, LZ
Mutschler, E
Christians, U
Citation: A. Soldner et al., Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and Caco-2 cell monolayers, BR J PHARM, 129(6), 2000, pp. 1235-1243
Authors:
Serkova, N
Litt, L
Leibfritz, D
Hausen, B
Morris, RE
James, TL
Benet, LZ
Christians, U
Citation: N. Serkova et al., The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates, BR J PHARM, 129(3), 2000, pp. 485-492
Authors:
Hausen, B
Boeke, K
Berry, GJ
Christians, U
Schuler, W
Morris, RE
Citation: B. Hausen et al., Successful treatment of acute, ongoing rat lung allograft rejection with the novel immunosuppressant SDZ-RAD, ANN THORAC, 69(3), 2000, pp. 904-909
Authors:
Kirchner, GI
Vidal, C
Jacobsen, W
Franzke, A
Hallensleben, K
Christians, U
Sewing, KF
Citation: Gi. Kirchner et al., Simultaneous on-line extraction and analysis of sirolimus (rapamycin) and ciclosporin in blood by liquid chromatography electrospray mass spectrometry, J CHROMAT B, 721(2), 1999, pp. 285-294
Authors:
Gummert, JF
Christians, U
Barten, M
Silva, H
Morris, RE
Citation: Jf. Gummert et al., High-performance liquid chromatographic assay with a simple extraction procedure for sensitive quantification of mycophenolic acid in rat and human plasma, J CHROMAT B, 721(2), 1999, pp. 321-326