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Results: 1-25 | 26-27
Results: 1-25/27
AN ORALLY BIOAVAILABLE PYRROLINONE INHIBITOR OF HIV-1 PROTEASE - COMPUTATIONAL ANALYSIS AND X-RAY CRYSTAL-STRUCTURE OF THE ENZYME COMPLEX
Authors: SMITH AB HIRSCHMANN R PASTERNAK A YAO WQ SPRENGELER PA HOLLOWAY MK KUO LC CHEN ZG DARKE PL SCHLEIF WA
Citation: Ab. Smith et al., AN ORALLY BIOAVAILABLE PYRROLINONE INHIBITOR OF HIV-1 PROTEASE - COMPUTATIONAL ANALYSIS AND X-RAY CRYSTAL-STRUCTURE OF THE ENZYME COMPLEX, Journal of medicinal chemistry, 40(16), 1997, pp. 2440-2444
DIMERIZATION AND ACTIVATION OF THE HERPES-SIMPLEX VIRUS TYPE-1 PROTEASE
Authors: SCHMIDT U DARKE PL
Citation: U. Schmidt et Pl. Darke, DIMERIZATION AND ACTIVATION OF THE HERPES-SIMPLEX VIRUS TYPE-1 PROTEASE, The Journal of biological chemistry, 272(12), 1997, pp. 7732-7735
NONPEPTIDAL P-2 LIGANDS FOR HIV PROTEASE INHIBITORS - STRUCTURE-BASEDDESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION
Authors: GHOSH AK KINCAID JF WALTERS DE CHEN Y CHAUDHURI NC THOMPSON WJ CULBERSON C FITZGERALD PMD LEE HY MCKEE SP MUNSON PM DUONG TT DARKE PL ZUGAY JA SCHLEIF WA AXEL MG LIN J HUFF JR
Citation: Ak. Ghosh et al., NONPEPTIDAL P-2 LIGANDS FOR HIV PROTEASE INHIBITORS - STRUCTURE-BASEDDESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION, Journal of medicinal chemistry, 39(17), 1996, pp. 3278-3290
A-PRIORI PREDICTION OF ACTIVITY FOR HIV-1 PROTEASE INHIBITORS EMPLOYING ENERGY MINIMIZATION IN THE ACTIVE-SITE (VOL 38, PG 308, 1995)
Authors: HOLLOWAY MK WAI JM HALGREN TA FITZGERALD PMD VACCA JP DORSEY BD LEVIN RB THOMPSON WJ CHEN LJ DESOLMS SJ GAFFIN N GHOSH AK GIULIANI EA GRAHAM SL GUARE JP HUNGATE RW LYLE TA SANDERS WM TUCKER TJ WIGGINS M WISCOUNT CM WOLTERSDORF OW YOUNG SD DARKE PL ZUGAY JA
Citation: Mk. Holloway et al., A-PRIORI PREDICTION OF ACTIVITY FOR HIV-1 PROTEASE INHIBITORS EMPLOYING ENERGY MINIMIZATION IN THE ACTIVE-SITE (VOL 38, PG 308, 1995), Journal of medicinal chemistry, 39(11), 1996, pp. 2280-2280
ELUCIDATION OF BASIC MECHANISTIC AND KINETIC-PROPERTIES OF INFLUENZA ENDONUCLEASE USING CHEMICALLY SYNTHESIZED RNAS
Authors: OLSEN DB BENSELER F COLE JL STAHLHUT MW DEMPSKI RE DARKE PL KUO LC
Citation: Db. Olsen et al., ELUCIDATION OF BASIC MECHANISTIC AND KINETIC-PROPERTIES OF INFLUENZA ENDONUCLEASE USING CHEMICALLY SYNTHESIZED RNAS, The Journal of biological chemistry, 271(13), 1996, pp. 7435-7439
ACTIVE HUMAN CYTOMEGALOVIRUS PROTEASE IS A DIMER
Authors: DARKE PL COLE JL WAXMAN L HALL DL SARDANA MK KUO LC
Citation: Pl. Darke et al., ACTIVE HUMAN CYTOMEGALOVIRUS PROTEASE IS A DIMER, The Journal of biological chemistry, 271(13), 1996, pp. 7445-7449
SYNTHESIS AND EVALUATION OF PYRIDYL ANALOGS OF L-735,524 - POTENT HIV-1 PROTEASE INHIBITORS (VOL 4, PG 2769, 1994)
Authors: DORSEY BD MCDANIEL SL LEVIN RB VACCA JP DARKE PL ZUGAY JA EMINI EA SCHLEIF WA LIN JH CHEN IW HOLLOWAY MK ANDERSON PS HUFF JR
Citation: Bd. Dorsey et al., SYNTHESIS AND EVALUATION OF PYRIDYL ANALOGS OF L-735,524 - POTENT HIV-1 PROTEASE INHIBITORS (VOL 4, PG 2769, 1994), Bioorganic & medicinal chemistry letters, 5(7), 1995, pp. 773-773
CYCLOALKYLPIPERAZINES AS HIV-1 PROTEASE INHIBITORS - ENHANCED ORAL ABSORPTION
Authors: KIM BM EVANS BE GILBERT KF HANIFIN CM VACCA JP MICHELSON SR DARKE PL ZUGAY JA EMINI EA SCHLEIF W LIN JH CHEN IW VASTAG K ANDERSON PS HUFF JR
Citation: Bm. Kim et al., CYCLOALKYLPIPERAZINES AS HIV-1 PROTEASE INHIBITORS - ENHANCED ORAL ABSORPTION, Bioorganic & medicinal chemistry letters, 5(22), 1995, pp. 2707-2712
THIOPHENE DERIVATIVES AS EXTREMELY HIGH-AFFINITY P-3' LIGANDS FOR THEHYDROXYETHYLPIPERAZINE CLASS OF HIV-1 PROTEASE INHIBITORS
Authors: KIM BM GUARE JP VACCA JP MICHELSON SR DARKE PL ZUGAY JA EMINI EA SCHLEIF W LIN JH CHEN IW VASTAG K ANDERSON PS HUFF JR
Citation: Bm. Kim et al., THIOPHENE DERIVATIVES AS EXTREMELY HIGH-AFFINITY P-3' LIGANDS FOR THEHYDROXYETHYLPIPERAZINE CLASS OF HIV-1 PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 5(2), 1995, pp. 185-190
SUBSTITUTED ALKYLPYRIDINES AS P-3' LIGANDS FOR THE HYDROXYETHYLPIPERAZINE CLASS OF HIV-1 PROTEASE INHIBITORS - IMPROVED PHARMACOKINETIC PROFILES
Authors: KIM BM HANIFIN CM ZARTMAN CB VACCA JP MICHELSON SR LIN JH CHEN IW VASTAG K DARKE PL ZUGAY JA EMINI EA SCHLEIF W ANDERSON PS HUFF JR
Citation: Bm. Kim et al., SUBSTITUTED ALKYLPYRIDINES AS P-3' LIGANDS FOR THE HYDROXYETHYLPIPERAZINE CLASS OF HIV-1 PROTEASE INHIBITORS - IMPROVED PHARMACOKINETIC PROFILES, Bioorganic & medicinal chemistry letters, 5(19), 1995, pp. 2239-2244
A-PRIORI PREDICTION OF ACTIVITY FOR HIV-1 PROTEASE INHIBITORS EMPLOYING ENERGY MINIMIZATION IN THE ACTIVE-SITE
Authors: HOLLOWAY MK WAI JM HALGREN TA FITZGERALD PMD VACCA JP DORSEY BD LEVIN RB THOMPSON WJ CHEN LJ DESOLMS SJ GAFFIN N GHOSH AK GIULIANI EA GRAHAM SL GUARE JP HUNGATE RW LYLE TA SANDERS WM TUCKER TJ WIGGINS M WISCOUNT CM WOLTERSDORF OW YOUNG SD DARKE PL ZUGAY JA
Citation: Mk. Holloway et al., A-PRIORI PREDICTION OF ACTIVITY FOR HIV-1 PROTEASE INHIBITORS EMPLOYING ENERGY MINIMIZATION IN THE ACTIVE-SITE, Journal of medicinal chemistry, 38(2), 1995, pp. 305-317
ACTIVATION OF THE HERPES-SIMPLEX VIRUS TYPE-1 PROTEASE
Authors: HALL DL DARKE PL
Citation: Dl. Hall et Pl. Darke, ACTIVATION OF THE HERPES-SIMPLEX VIRUS TYPE-1 PROTEASE, The Journal of biological chemistry, 270(39), 1995, pp. 22697-22700
PYRROLINONE-BASED HIV PROTEASE INHIBITORS - DESIGN, SYNTHESIS, AND ANTIVIRAL ACTIVITY - EVIDENCE FOR IMPROVED TRANSPORT
Authors: SMITH AB HIRSCHMANN R PASTERNAK A GUZMAN MC YOKOYAMA A SPRENGELER PA DARKE PL EMINI EA SCHLEIF WA
Citation: Ab. Smith et al., PYRROLINONE-BASED HIV PROTEASE INHIBITORS - DESIGN, SYNTHESIS, AND ANTIVIRAL ACTIVITY - EVIDENCE FOR IMPROVED TRANSPORT, Journal of the American Chemical Society, 117(45), 1995, pp. 11113-11123
CONFORMATIONALLY CONSTRAINED HIV-1 PROTEASE INHIBITORS
Authors: VACCA JP FITZGERALD PMD HOLLOWAY MK HUNGATE RW STARBUCK KE CHEN LJ DARKE PL ANDERSON PS HUFF JR
Citation: Jp. Vacca et al., CONFORMATIONALLY CONSTRAINED HIV-1 PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 4(3), 1994, pp. 499-504
SYNTHESIS AND EVALUATION OF PYRIDYL ANALOGS OF L-735,524 - POTENT HIV-1 PROTEASE INHIBITORS
Authors: DORSEY BD MCDANIEL SL LEVIN RB VACCA JP DARKE PL ZUGAY JA EMINI EA SCHLEIF WA LIN JH CHEN IW HOLLOWAY MK ANDERSON PS HUFF JR
Citation: Bd. Dorsey et al., SYNTHESIS AND EVALUATION OF PYRIDYL ANALOGS OF L-735,524 - POTENT HIV-1 PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 4(23), 1994, pp. 2769-2774
A NEW HYDROXYETHYLAMINE CLASS OF HIV-1 PROTEASE INHIBITORS WITH HIGH ANTIVIRAL POTENCY AND ORAL BIOAVAILABILITY
Authors: KIM BM VACCA JP GUARE JP HANIFIN CM MICHELSON SR DARKE PL ZUGAY JA EMINI EA SCHLEIF W LIN JH CHEN IW VASTAG K OSTOVIC D ANDERSON PS HUFF JR
Citation: Bm. Kim et al., A NEW HYDROXYETHYLAMINE CLASS OF HIV-1 PROTEASE INHIBITORS WITH HIGH ANTIVIRAL POTENCY AND ORAL BIOAVAILABILITY, Bioorganic & medicinal chemistry letters, 4(19), 1994, pp. 2273-2278
NOVEL CONFORMATIONALLY CONSTRAINED HIV-1 PROTEASE INHIBITORS - RATIONAL DESIGN, ENZYME-INHIBITION, AND X-RAY STRUCTURE OF AN ENZYME-INHIBITOR COMPLEX
Authors: KIM BM VACCA JP FITZGERALD PMD DARKE PL HOLLOWAY MK GUARE JP HANIFIN CM ARFORDBICKERSTAFF DJ ZUGAY JA WAI JM ANDERSON PS HUFF JR
Citation: Bm. Kim et al., NOVEL CONFORMATIONALLY CONSTRAINED HIV-1 PROTEASE INHIBITORS - RATIONAL DESIGN, ENZYME-INHIBITION, AND X-RAY STRUCTURE OF AN ENZYME-INHIBITOR COMPLEX, Bioorganic & medicinal chemistry letters, 4(18), 1994, pp. 2199-2204
THE DESIGN AND SYNTHESIS OF ORALLY BIOAVAILABLE HIV-1 PROTEASE INHIBITORS
Authors: HUFF JR VACCA JP DORSEY BD THOMPSON WJ GHOSH AK HUNGATE RW LEE HY DARKE PL EMINI EA SCHLEIF WA LIN JH CHEN IW HOLLOWAY MK ANDERSON PS
Citation: Jr. Huff et al., THE DESIGN AND SYNTHESIS OF ORALLY BIOAVAILABLE HIV-1 PROTEASE INHIBITORS, Journal of cellular biochemistry, 1994, pp. 130-130
L-735,524 - AN ORALLY BIOAVAILABLE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE INHIBITOR
Authors: VACCA JP DORSEY BD SCHLEIF WA LEVIN RB MCDANIEL SL DARKE PL ZUGAY J QUINTERO JC BLAHY OM ROTH E SARDANA VV SCHLABACH AJ GRAHAM PI CONDRA JH GOTLIB L HOLLOWAY MK LIN J CHEN IW VASTAG K OSTOVIC D ANDERSON PS EMINI EA HUFF JR
Citation: Jp. Vacca et al., L-735,524 - AN ORALLY BIOAVAILABLE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE INHIBITOR, Proceedings of the National Academy of Sciences of the United Statesof America, 91(9), 1994, pp. 4096-4100
THE DEVELOPMENT OF CYCLIC SULFOLANES AS NOVEL AND HIGH-AFFINITY P(2) LIGANDS FOR HIV-1 PROTEASE INHIBITORS
Authors: GHOSH AK LEE HY THOMPSON WJ CULBERSON C HOLLOWAY MK MCKEE SP MUNSON PM DUONG TT SMITH AM DARKE PL ZUGAY JA EMINI EA SCHLEIF WA HUFF JR ANDERSON PS
Citation: Ak. Ghosh et al., THE DEVELOPMENT OF CYCLIC SULFOLANES AS NOVEL AND HIGH-AFFINITY P(2) LIGANDS FOR HIV-1 PROTEASE INHIBITORS, Journal of medicinal chemistry, 37(8), 1994, pp. 1177-1188
L-735,524 - THE DESIGN OF A POTENT AND ORALLY BIOAVAILABLE HIV PROTEASE INHIBITOR
Authors: DORSEY BD LEVIN RB MCDANIEL SL VACCA JP GUARE JP DARKE PL ZUGAY JA EMINI EA SCHLEIF WA QUINTERO JC LIN JH CHEN IW HOLLOWAY MK FITZGERALD PMD AXEL MG OSTOVIC D ANDERSON PS HUFF JR
Citation: Bd. Dorsey et al., L-735,524 - THE DESIGN OF A POTENT AND ORALLY BIOAVAILABLE HIV PROTEASE INHIBITOR, Journal of medicinal chemistry, 37(21), 1994, pp. 3443-3451
DESIGN AND SYNTHESIS OF PEPTIDOMIMETIC INHIBITORS OF HIV-1 PROTEASE AND RENIN - EVIDENCE FOR IMPROVED TRANSPORT
Authors: SMITH AB HIRSCHMANN R PASTERNAK A AKAISHI R GUZMAN MC JONES DR KEENAN TP SPRENGELER PA DARKE PL EMINI EA HOLLOWAY MK SCHLEIF WA
Citation: Ab. Smith et al., DESIGN AND SYNTHESIS OF PEPTIDOMIMETIC INHIBITORS OF HIV-1 PROTEASE AND RENIN - EVIDENCE FOR IMPROVED TRANSPORT, Journal of medicinal chemistry, 37(2), 1994, pp. 215-218
CRYSTAL-STRUCTURE AT 1.9-ANGSTROM RESOLUTION OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV)-II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
Authors: CHEN ZG LI Y CHEN E HALL DL DARKE PL CULBERSON C SHAFER JA KUO LC
Citation: Zg. Chen et al., CRYSTAL-STRUCTURE AT 1.9-ANGSTROM RESOLUTION OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV)-II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES, The Journal of biological chemistry, 269(42), 1994, pp. 26344-26348
PURIFICATION OF ACTIVE HERPES-SIMPLEX VIRUS-1 PROTEASE EXPRESSED IN ESCHERICHIA-COLI
Authors: DARKE PL CHEN E HALL DL SARDANA MK VELOSKI CA LAFEMINA RL SHAFER JA KUO LC
Citation: Pl. Darke et al., PURIFICATION OF ACTIVE HERPES-SIMPLEX VIRUS-1 PROTEASE EXPRESSED IN ESCHERICHIA-COLI, The Journal of biological chemistry, 269(29), 1994, pp. 18708-18711
DISSOCIATION AND ASSOCIATION OF THE HIV-1 PROTEASE DIMER SUBUNITS - EQUILIBRIA AND RATES
Authors: DARKE PL JORDAN SP HALL DL ZUGAY JA SHAFER JA KUO LC
Citation: Pl. Darke et al., DISSOCIATION AND ASSOCIATION OF THE HIV-1 PROTEASE DIMER SUBUNITS - EQUILIBRIA AND RATES, Biochemistry, 33(1), 1994, pp. 98-105
Risultati: 1-25 | 26-27