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Results: 1-9 |
Results: 9
Farnesyl protein transferase inhibition: A novel approach to anti-tumor therapy. The discovery and development of SCH 66336
Authors: Ganguly, AK Doll, RJ Girijavallabhan, VM
Citation: Ak. Ganguly et al., Farnesyl protein transferase inhibition: A novel approach to anti-tumor therapy. The discovery and development of SCH 66336, CURR MED CH, 8(12), 2001, pp. 1419-1436
The farnesyl transferase inhibitor SCH 66336 induces a G(2) -> M or G(1) pause in sensitive human tumor cell lines
Authors: Ashar, HR James, L Gray, K Carr, D McGuirk, M Maxwell, E Black, S Armstrong, L Doll, RJ Taveras, AG Bishop, WR Kirschmeier, P
Citation: Hr. Ashar et al., The farnesyl transferase inhibitor SCH 66336 induces a G(2) -> M or G(1) pause in sensitive human tumor cell lines, EXP CELL RE, 262(1), 2001, pp. 17-27
Tricyclic farnesyl protein transferase inhibitors - Antitumor activity andeffects on protein prenylation
Authors: Bishop, WR Pai, JJK Armstrong, L Dalton, MB Doll, RJ Taveras, A Njoroge, G Sinensky, M Zhang, F Liu, M Kirschmeier, P
Citation: Wr. Bishop et al., Tricyclic farnesyl protein transferase inhibitors - Antitumor activity andeffects on protein prenylation, CANC DRUG, 8, 2001, pp. 87-101
Biological effects and mechanism of action of farnesyl transferase inhibitors
Authors: Ashar, HR Armstrong, L James, LJ Carr, DM Gray, K Taveras, A Doll, RJ Bishop, WR Kirschmeier, PT
Citation: Hr. Ashar et al., Biological effects and mechanism of action of farnesyl transferase inhibitors, CHEM RES T, 13(10), 2000, pp. 949-952
Synthesis of C-11 methyl-substituted benzocycloheptapyridine inhibitors offarnesyl protein transferase
Authors: Njoroge, FG Vibulbhan, B Wong, JK White, SK Wong, SC Carruthers, NI Kaminski, JJ Doll, RJ Girijavallabhan, V Ganguly, AK
Citation: Fg. Njoroge et al., Synthesis of C-11 methyl-substituted benzocycloheptapyridine inhibitors offarnesyl protein transferase, ORG LETT, 1(9), 1999, pp. 1371-1373
Atropisomeric trihalobenzocycloheptapyridine analogues provide stereoselective FPT inhibitors with antitumor activity
Authors: Njoroge, FG Vibulbhan, B Bishop, WR Kirschmeier, P Bryant, MS Nomeir, AA Liu, M Doll, RJ Girijavallabhan, VM Ganguly, AK
Citation: Fg. Njoroge et al., Atropisomeric trihalobenzocycloheptapyridine analogues provide stereoselective FPT inhibitors with antitumor activity, BIO MED CH, 7(5), 1999, pp. 861-867
Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude mice
Authors: Liu, M Bryant, MS Chen, JP Lee, SN Yaremko, B Li, ZJ Dell, J Lipari, P Malkowski, M Prioli, N Rossman, RR Korfmacher, WA Nomeir, AA Lin, CC Mallams, AK Doll, RJ Catino, JJ Girijavallabhan, VM Kirschmeier, P Bishop, WR
Citation: M. Liu et al., Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude mice, CANC CHEMOT, 43(1), 1999, pp. 50-58
Identification of pharmacokinetically stable 3,10-dibromo-8-chlorobenzocycloheptapyridine farnesyl protein transferase inhibitors with potent enzyme and cellular activities
Authors: Taveras, AG Deskus, J Chao, JP Vaccaro, CJ Njoroge, FG Vibulbhan, B Pinto, P Remiszewski, S del Rosario, J Doll, RJ Alvarez, C Lalwani, T Mallams, AK Rossman, RR Afonso, A Girijavallabhan, VM Ganguly, AK Pramanik, B Heimark, L Bishop, WR Wang, L Kirschmeier, P James, L Carr, D Patton, R Bryant, MS Nomeir, AA Liu, M
Citation: Ag. Taveras et al., Identification of pharmacokinetically stable 3,10-dibromo-8-chlorobenzocycloheptapyridine farnesyl protein transferase inhibitors with potent enzyme and cellular activities, J MED CHEM, 42(14), 1999, pp. 2651-2661
Tricyclic farnesyl protein transferase inhibitors: Crystallographic and calorimetric studies of structure-activity relationships
Authors: Strickland, CL Weber, PC Windsor, WT Wu, Z Le, HV Albanese, MM Alvarez, CS Cesarz, D del Rosario, J Deskus, J Mallams, AK Njoroge, FG Piwinski, JJ Remiszewski, S Rossman, RR Taveras, AG Vibulbhan, B Doll, RJ Girijavallabhan, VM Ganguly, AK
Citation: Cl. Strickland et al., Tricyclic farnesyl protein transferase inhibitors: Crystallographic and calorimetric studies of structure-activity relationships, J MED CHEM, 42(12), 1999, pp. 2125-2135
Risultati: 1-9 |