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Protease inhibitors
Authors: Fairlie, DP
Citation: Dp. Fairlie, Protease inhibitors, CURR MED CH, 8(8), 2001, pp. NIL_2-NIL_2
Macrocycles mimic the extended peptide conformation recognized by aspartic, serine, cysteine and metallo proteases
Authors: Tyndall, JDA Fairlie, DP
Citation: Jda. Tyndall et Dp. Fairlie, Macrocycles mimic the extended peptide conformation recognized by aspartic, serine, cysteine and metallo proteases, CURR MED CH, 8(8), 2001, pp. 893-907
Species dependence for binding of small molecule agonist and antagonists to the C5a receptor on polymorphonuclear leukocytes
Authors: Woodruff, TM Strachan, AJ Sanderson, SD Monk, PN Wong, AK Fairlie, DP Taylor, SM
Citation: Tm. Woodruff et al., Species dependence for binding of small molecule agonist and antagonists to the C5a receptor on polymorphonuclear leukocytes, INFLAMMATIO, 25(3), 2001, pp. 171-177
Proteolysis of human hemoglobin by schistosome cathepsin D
Authors: Brindley, PJ Kalinna, BH Wong, JYM Bogitsh, BJ King, LT Smyth, DJ Verity, CK Abbenante, G Brinkworth, RI Fairlie, DP Smythe, ML Milburn, PJ Bielefeldt-Ohmann, H Zheng, Y McManus, DP
Citation: Pj. Brindley et al., Proteolysis of human hemoglobin by schistosome cathepsin D, MOL BIOCH P, 112(1), 2001, pp. 103-112
Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors
Authors: Leung, D Schroder, K White, H Fang, NX Stoermer, MJ Abbenante, G Martin, JL Young, PR Fairlie, DP
Citation: D. Leung et al., Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors, J BIOL CHEM, 276(49), 2001, pp. 45762-45771
Modulation of ligand selectivity by mutation of the first extracellular loop of the human C5a receptor
Authors: Cain, SA Woodruff, TM Taylor, SM Fairlie, DP Sanderson, SD Monk, PN
Citation: Sa. Cain et al., Modulation of ligand selectivity by mutation of the first extracellular loop of the human C5a receptor, BIOCH PHARM, 61(12), 2001, pp. 1571-1579
Novel cylindrical, conical, and macrocyclic peptides from the cyclooligomerization of functionalized thiazole amino acids
Authors: Singh, Y Sokolenko, N Kelso, MJ Gahan, LR Abbenante, G Fairlie, DP
Citation: Y. Singh et al., Novel cylindrical, conical, and macrocyclic peptides from the cyclooligomerization of functionalized thiazole amino acids, J AM CHEM S, 123(2), 2001, pp. 333-334
Regulators of the anaphylatoxin C5a
Authors: Taylor, SM Fairlie, DP
Citation: Sm. Taylor et Dp. Fairlie, Regulators of the anaphylatoxin C5a, EXPERT OP T, 10(4), 2000, pp. 449-458
Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells
Authors: Qiu, L Burgess, A Fairlie, DP Leonard, H Parsons, PG Gabrielli, BG
Citation: L. Qiu et al., Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells, MOL BIOL CE, 11(6), 2000, pp. 2069
Solution structures in aqueous SDS micelles of two amyloid beta peptides of A beta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F)
Authors: Poulsen, SA Watson, AA Fairlie, DP Craik, DJ
Citation: Sa. Poulsen et al., Solution structures in aqueous SDS micelles of two amyloid beta peptides of A beta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F), J STRUCT B, 130(2-3), 2000, pp. 142-152
Cell phenotype as a target of drug therapy in chronic inflammatory diseases
Authors: Shiels, IA Taylor, SM Fairlie, DP
Citation: Ia. Shiels et al., Cell phenotype as a target of drug therapy in chronic inflammatory diseases, MED HYPOTH, 54(2), 2000, pp. 193-197
Conformations of cyclic octapeptides and the influence of heterocyclic ring constraints upon calcium binding
Authors: Cusack, RM Grondahl, L Abbenante, G Fairlie, DP Gahan, LR Hanson, GR Hambley, TW
Citation: Rm. Cusack et al., Conformations of cyclic octapeptides and the influence of heterocyclic ring constraints upon calcium binding, J CHEM S P2, (2), 2000, pp. 323-331
Characterization of copper interactions with Alzheimer amyloid beta peptides: Identification of an attomolar-affinity copper binding site on amyloid beta 1-42
Authors: Atwood, CS Scarpa, RC Huang, XD Moir, RD Jones, WD Fairlie, DP Tanzi, RE Bush, AI
Citation: Cs. Atwood et al., Characterization of copper interactions with Alzheimer amyloid beta peptides: Identification of an attomolar-affinity copper binding site on amyloid beta 1-42, J NEUROCHEM, 75(3), 2000, pp. 1219-1233
Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processing
Authors: Fairlie, DP Tyndall, JDA Reid, RC Wong, AK Abbenante, G Scanlon, MJ March, DR Bergman, DA Chai, CLL Burkett, BA
Citation: Dp. Fairlie et al., Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processing, J MED CHEM, 43(7), 2000, pp. 1271-1281
Protease inhibitors: Current status and future prospects
Authors: Leung, D Abbenante, G Fairlie, DP
Citation: D. Leung et al., Protease inhibitors: Current status and future prospects, J MED CHEM, 43(3), 2000, pp. 305-341
Synthesis, stability, antiviral activity, and protease-bound structures ofsubstrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease
Authors: Tyndall, JDA Reid, RC Tyssen, DP Jardine, DK Todd, B Passmore, M March, DR Pattenden, LK Bergman, DA Alewood, D Hu, SH Alewood, PF Birch, CJ Martin, JL Fairlie, DP
Citation: Jda. Tyndall et al., Synthesis, stability, antiviral activity, and protease-bound structures ofsubstrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease, J MED CHEM, 43(19), 2000, pp. 3495-3504
A new small molecule C5a receptor antagonist inhibits the reverse-passive arthus reaction and endotoxic shock in rats
Authors: Strachan, AJ Woodruff, TM Haaima, G Fairlie, DP Taylor, SM
Citation: Aj. Strachan et al., A new small molecule C5a receptor antagonist inhibits the reverse-passive arthus reaction and endotoxic shock in rats, J IMMUNOL, 164(12), 2000, pp. 6560-6565
Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents
Authors: Andrews, KT Walduck, A Kelso, MJ Fairlie, DP Saul, A Parsons, PG
Citation: Kt. Andrews et al., Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents, INT J PARAS, 30(6), 2000, pp. 761-768
Inhibition of C5a-induced neutrophil chemotaxis and macrophage cytokine production in vitro by a new C5a receptor antagonist
Authors: Haynes, DR Harkin, DG Bignold, LP Hutchens, MJ Taylor, SM Fairlie, DP
Citation: Dr. Haynes et al., Inhibition of C5a-induced neutrophil chemotaxis and macrophage cytokine production in vitro by a new C5a receptor antagonist, BIOCH PHARM, 60(5), 2000, pp. 729-733
Small peptides do not inhibit human non-pancreatic secretory phospholipase-A(2) (type IIA)
Authors: Clark, CI Reid, RC McGeary, RP Schafer, K Fairlie, DP
Citation: Ci. Clark et al., Small peptides do not inhibit human non-pancreatic secretory phospholipase-A(2) (type IIA), BIOC BIOP R, 274(3), 2000, pp. 831-834
Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site
Authors: Abbenante, G Kovacs, DM Leung, DL Craik, DJ Tanzi, RE Fairlie, DP
Citation: G. Abbenante et al., Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site, BIOC BIOP R, 268(1), 2000, pp. 133-135
The first solution stucture of a single alpha-helical turn. A pentapeptidealpha-helix stabilized by a metal clip
Authors: Kelso, MJ Hoang, HN Appleton, TG Fairlie, DP
Citation: Mj. Kelso et al., The first solution stucture of a single alpha-helical turn. A pentapeptidealpha-helix stabilized by a metal clip, J AM CHEM S, 122(42), 2000, pp. 10488-10489
Is oxidative damage by beta-amyloid and prion peptides mediated by hydrogen atom transfer from glycine alpha-carbon to methionine sulfur within beta-sheets?
Authors: Rauk, A Armstrong, DA Fairlie, DP
Citation: A. Rauk et al., Is oxidative damage by beta-amyloid and prion peptides mediated by hydrogen atom transfer from glycine alpha-carbon to methionine sulfur within beta-sheets?, J AM CHEM S, 122(40), 2000, pp. 9761-9767
Interaction of zinc(II) with the cyclic octapeptides, cyclo[Ile(Oxn)-D-Val(Thz)](2) and ascidiacyclamide, a cyclic peptide from Lissoclinum patella
Authors: Grondahl, L Sokolenko, N Abbenante, G Fairlie, DP Hanson, GR Gahan, LR
Citation: L. Grondahl et al., Interaction of zinc(II) with the cyclic octapeptides, cyclo[Ile(Oxn)-D-Val(Thz)](2) and ascidiacyclamide, a cyclic peptide from Lissoclinum patella, J CHEM S DA, (8), 1999, pp. 1227-1234
The possible origin of free radicals from amyloid beta peptides in Alzheimer's disease
Authors: Bush, AI Huang, XD Fairlie, DP
Citation: Ai. Bush et al., The possible origin of free radicals from amyloid beta peptides in Alzheimer's disease, NEUROBIOL A, 20(3), 1999, pp. 335-337
Risultati: 1-25 | 26-37