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Results: 1-16 |
Results: 16
Design, synthesis and preliminary evaluation of novel 3 '-substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors
Authors: Pellicciari, R Costantino, G Marinozzi, M Macchiarulo, A Amori, L Flor, PJ Gasparini, F Kuhn, R Urwyler, S
Citation: R. Pellicciari et al., Design, synthesis and preliminary evaluation of novel 3 '-substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors, BIOORG MED, 11(24), 2001, pp. 3179-3182
An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors
Authors: Bruno, V Battaglia, G Copani, A Cespedes, VM Galindo, MF Cena, V Sanchez-Prieto, J Gasparini, F Kuhn, R Flor, PJ Nicoletti, F
Citation: V. Bruno et al., An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors, EUR J NEURO, 13(8), 2001, pp. 1469-1478
Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs
Authors: Bruno, V Battaglia, G Copani, A D'Onofrio, M Di Iorio, P De Blasi, A Melchiorri, D Flor, PJ Nicoletti, F
Citation: V. Bruno et al., Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs, J CEREBR B, 21(9), 2001, pp. 1013-1033
Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7
Authors: Sansig, G Bushell, TJ Clarke, VRJ Rozov, A Burnashev, N Portet, C Gasparini, F Schmutz, M Klebs, K Shigemoto, R Flor, PJ Kuhn, R Knoepfel, T Schroeder, M Hampson, DR Collett, VJ Zhang, CX Duvoisin, RM Collingridge, GL van der Putten, H
Citation: G. Sansig et al., Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7, J NEUROSC, 21(22), 2001, pp. 8734-8745
Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive functionI. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain
Authors: Walker, K Bowes, M Panesar, M Davis, A Gentry, C Kesingland, A Gasparini, F Spooren, W Stoehr, N Pagano, A Flor, PJ Vranesic, I Lingenhoehl, K Johnson, EC Varney, M Urban, L Kuhn, R
Citation: K. Walker et al., Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive functionI. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain, NEUROPHARM, 40(1), 2001, pp. 1-9
Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III
Authors: Amori, L Costantino, G Marinozzi, M Pellicciari, R Gasparini, F Flor, PJ Kuhn, R Vranesic, I
Citation: L. Amori et al., Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III, BIOORG MED, 10(13), 2000, pp. 1447-1450
(+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist
Authors: Gasparini, F Inderbitzin, W Francotte, E Lecis, G Richert, P Dragic, Z Kuhn, R Flor, PJ
Citation: F. Gasparini et al., (+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist, BIOORG MED, 10(11), 2000, pp. 1241-1244
Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death
Authors: Bruno, V Battaglia, G Ksiazek, I van der Putten, H Catania, MV Giuffrida, R Lukic, S Leonhardt, T Inderbitzin, W Gasparini, F Kuhn, R Hampson, DR Nicoletti, F Flor, PJ
Citation: V. Bruno et al., Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death, J NEUROSC, 20(17), 2000, pp. 6413-6420
Distinct influence of the group III metabotropic glutamate receptor agonist (R,S)-4-phosphonophenylglycine [(R,S)-PPG] on different forms of neuronaldamage
Authors: Henrich-Noack, P Flor, PJ Sabelhaus, CF Prass, K Dirnagl, U Gasparini, F Sauter, A Rudin, M Reymann, KG
Citation: P. Henrich-noack et al., Distinct influence of the group III metabotropic glutamate receptor agonist (R,S)-4-phosphonophenylglycine [(R,S)-PPG] on different forms of neuronaldamage, NEUROPHARM, 39(5), 2000, pp. 911-917
Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective
Authors: Bruno, V Ksiazek, I Battaglia, G Lukic, S Leonhardt, T Sauer, D Gasparini, F Kuhn, R Nicoletti, F Flor, PJ
Citation: V. Bruno et al., Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective, NEUROPHARM, 39(12), 2000, pp. 2223-2230
Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino-1a,2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester
Authors: Ott, D Floersheim, P Inderbitzin, W Stoehr, N Francotte, E Lecis, G Richert, P Rihs, G Flor, PJ Kuhn, R Gasparini, F
Citation: D. Ott et al., Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino-1a,2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester, J MED CHEM, 43(23), 2000, pp. 4428-4436
The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan [b]chromen-1 alpha-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group Imetabotropic glutamate receptors
Authors: Pagano, A Ruegg, D Litschig, S Stoehr, N Stierlin, C Heinrich, M Floersheim, P Prezeau, L Carroll, F Pin, JP Cambria, A Vranesic, I Flor, PJ Gasparini, F Kuhn, R
Citation: A. Pagano et al., The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan [b]chromen-1 alpha-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group Imetabotropic glutamate receptors, J BIOL CHEM, 275(43), 2000, pp. 33750-33758
2-methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
Authors: Gasparini, F Lingenhohl, K Stoehr, N Flor, PJ Heinrich, M Vranesic, I Biollaz, M Allgeier, H Heckendorn, R Urwyler, S Varney, MA Johnson, EC Hess, SD Rao, SP Sacaan, AI Santori, EM Velicelebi, G Kuhn, R
Citation: F. Gasparini et al., 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist, NEUROPHARM, 38(10), 1999, pp. 1493-1503
CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding
Authors: Litschig, S Gasparini, F Rueegg, D Stoehr, N Flor, PJ Vranesic, I Prezeau, L Pin, JP Thomsen, C Kuhn, R
Citation: S. Litschig et al., CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding, MOLEC PHARM, 55(3), 1999, pp. 453-461
SIB-1757 and SIB-1893: Selective, noncompetitive antagonists of metabotropic glutamate receptor type 5
Authors: Varney, MA Cosford, NDP Jachec, C Rao, SP Sacaan, A Lin, FF Bleicher, L Santori, EM Flor, PJ Allgeier, H Gasparini, F Kuhn, R Hess, SD Velicelebi, G Johnson, EC
Citation: Ma. Varney et al., SIB-1757 and SIB-1893: Selective, noncompetitive antagonists of metabotropic glutamate receptor type 5, J PHARM EXP, 290(1), 1999, pp. 170-181
(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo
Authors: Gasparini, F Bruno, V Battaglia, G Lukic, S Leonhardt, T Inderbitzin, W Laurie, D Sommer, B Varney, MA Hess, SD Johnson, EC Kuhn, R Urwyler, S Sauer, D Portet, C Schmutz, M Nicoletti, F Flor, PJ
Citation: F. Gasparini et al., (R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo, J PHARM EXP, 289(3), 1999, pp. 1678-1687
Risultati: 1-16 |