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Results: 1-10 |
Results: 10
Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists
Authors: Witherington, J Bordas, V Cooper, DG Forbes, IT Gribble, AD Ife, RJ Berkhout, T Gohil, J Groot, PHE
Citation: J. Witherington et al., Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists, BIOORG MED, 11(16), 2001, pp. 2177-2180
A short and efficient synthesis of N-substituted indol-2-ones (oxindoles)
Authors: Forbes, IT
Citation: It. Forbes, A short and efficient synthesis of N-substituted indol-2-ones (oxindoles), TETRAHEDR L, 42(39), 2001, pp. 6943-6945
SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety
Authors: Wood, MD Reavill, C Trail, B Wilson, A Stean, T Kennett, GA Lightowler, S Blackburn, TP Thomas, D Gager, TL Riley, G Holland, V Bromidge, SM Forbes, IT Middlemiss, DN
Citation: Md. Wood et al., SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety, NEUROPHARM, 41(2), 2001, pp. 186-199
CCR2B receptor antagonists: Conversion of a weak HTS hit to a potent lead compound
Authors: Forbes, IT Cooper, DG Dodds, EK Hickey, DMB Ife, RJ Meeson, M Stockley, M Berkhout, TA Gohil, J Groot, PHE Moores, K
Citation: It. Forbes et al., CCR2B receptor antagonists: Conversion of a weak HTS hit to a potent lead compound, BIOORG MED, 10(16), 2000, pp. 1803-1806
1-[2-[(heteroaryloxy)heteroaryl]carbamoyl]indolines: Novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolyticagents
Authors: Bromidge, SM Dabbs, S Davies, S Duckworth, DM Forbes, IT Jones, GE Jones, J King, FD Saunders, DV Blackburn, TP Holland, V Kennett, GA Lightowler, S Middlemiss, DN Riley, GJ Trail, B Wood, MD
Citation: Sm. Bromidge et al., 1-[2-[(heteroaryloxy)heteroaryl]carbamoyl]indolines: Novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolyticagents, BIOORG MED, 10(16), 2000, pp. 1863-1866
1-[2-[(heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orallyactive 5-HT2C receptor inverse agonists
Authors: Bromidge, SM Davies, S Duckworth, DM Forbes, IT Jones, GE Jones, J King, FD Blackburn, TP Holland, V Kennett, GA Lightowler, S Middlemiss, DN Riley, GJ Trail, B Wood, MD
Citation: Sm. Bromidge et al., 1-[2-[(heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orallyactive 5-HT2C receptor inverse agonists, BIOORG MED, 10(16), 2000, pp. 1867-1870
Biarylcarbamoylindolines are novel and selective 5-HT2C receptor inverse agonists: Identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent
Authors: Bromidge, SM Dabbs, S Davies, DT Davies, S Duckworth, DM Forbes, IT Gaster, LM Ham, P Jones, GE King, FD Mulholland, KR Saunders, DV Wyman, PA Blaney, FE Clarke, SE Blackburn, TP Holland, V Kennett, GA Lightowler, S Middlemiss, DN Trail, B Riley, GJ Wood, MD
Citation: Sm. Bromidge et al., Biarylcarbamoylindolines are novel and selective 5-HT2C receptor inverse agonists: Identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent, J MED CHEM, 43(6), 2000, pp. 1123-1134
A novel, potent, and selective 5-HT7 antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)-ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)
Authors: Lovell, PJ Bromidge, SM Dabbs, S Duckworth, DM Forbes, IT Jennings, AJ King, FD Middlemiss, DN Rahman, SK Saunders, DV Collin, LL Hagan, JJ Riley, GJ Thomas, DR
Citation: Pj. Lovell et al., A novel, potent, and selective 5-HT7 antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)-ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970), J MED CHEM, 43(3), 2000, pp. 342-345
Model studies on a synthetically facile series of N-substituted phenyl-N '-pyridin-3-yl ureas leading to 1-(3-pyridylcarbamoyl) indolines that are potent and selective 5-HT2C/2B receptor antagonists
Authors: Bromidge, SM Dabbs, S Davies, DT Davies, S Duckworth, DM Forbes, IT Gadre, A Ham, P Jones, GE King, FD Saunders, DV Thewlis, KM Vyas, D Blackburn, TP Holland, V Kennett, GA Riley, GJ Wood, MD
Citation: Sm. Bromidge et al., Model studies on a synthetically facile series of N-substituted phenyl-N '-pyridin-3-yl ureas leading to 1-(3-pyridylcarbamoyl) indolines that are potent and selective 5-HT2C/2B receptor antagonists, BIO MED CH, 7(12), 1999, pp. 2767-2773
Highly stereoselective synthesis of exo and endo indolotropanes
Authors: Forbes, IT
Citation: It. Forbes, Highly stereoselective synthesis of exo and endo indolotropanes, TETRAHEDR L, 40(52), 1999, pp. 9293-9295
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