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Results: 1-25 | 26-44
Results: 1-25/44
Nicastrin binds to membrane tethered Notch
Authors: Chen, FS Yu, G Arawaka, S Nishimura, M Kawarai, T Yu, H Tandon, A Supala, A Song, YQ Rogaeva, E Milman, P Sato, C Yu, C Janus, C Lee, J Song, LX Zhang, LL Fraser, PE St George-Hyslop, PH
Citation: Fs. Chen et al., Nicastrin binds to membrane tethered Notch, NAT CELL BI, 3(8), 2001, pp. 751-754
Assembly of Alzheimer's amyloid-beta fibrils and approaches for therapeutic intervention
Authors: Yang, DS Serpell, LC Yip, CM McLaurin, J Chrishti, MA Horne, P Boudreau, L Kisilevsky, R Westaway, D Fraser, PE
Citation: Ds. Yang et al., Assembly of Alzheimer's amyloid-beta fibrils and approaches for therapeutic intervention, AMYLOID, 8, 2001, pp. 10-19
S100 beta interaction with tau is promoted by zinc and inhibited by hyperphosphorylation in Alzheimer's disease
Authors: Yu, WH Fraser, PE
Citation: Wh. Yu et Pe. Fraser, S100 beta interaction with tau is promoted by zinc and inhibited by hyperphosphorylation in Alzheimer's disease, J NEUROSC, 21(7), 2001, pp. 2240-2246
Distinguishable effects of Presenilin-1 and APP717 mutations on amyloid plaque deposition
Authors: Ishii, K Lippa, C Tomiyama, T Miyatake, F Ozawa, K Tamaoka, A Hasegawa, T Fraser, PE Shoji, S Nee, LE Pollen, DA St George-Hyslop, PH Ii, K Ohtake, T Kalaria, RN Rossor, MN Lantos, PL Cairns, NJ Farrer, LA Mori, H
Citation: K. Ishii et al., Distinguishable effects of Presenilin-1 and APP717 mutations on amyloid plaque deposition, NEUROBIOL A, 22(3), 2001, pp. 367-376
Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis
Authors: Jaikaran, ETAS Higham, CE Serpell, LC Zurdo, J Gross, M Clark, A Fraser, PE
Citation: Etas. Jaikaran et al., Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis, J MOL BIOL, 308(3), 2001, pp. 515-525
Amyloid-beta interactions with chondroitin sulfate-derived monosaccharidesand disaccharides - Implications for drug development
Authors: Fraser, PE Darabie, AA McLaurin, J
Citation: Pe. Fraser et al., Amyloid-beta interactions with chondroitin sulfate-derived monosaccharidesand disaccharides - Implications for drug development, J BIOL CHEM, 276(9), 2001, pp. 6412-6419
Cellular membrane composition defines A beta-lipid interactions
Authors: Waschuk, SA Elton, EA Darabie, AA Fraser, PE McLaurin, J
Citation: Sa. Waschuk et al., Cellular membrane composition defines A beta-lipid interactions, J BIOL CHEM, 276(36), 2001, pp. 33561-33568
Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2
Authors: Sato, N Imaizumi, K Manabe, T Taniguchi, M Hitomi, J Katayama, T Yoneda, T Morihara, T Yasuda, Y Takagi, T Kudo, T Tsuda, T Itoyama, Y Makifuchi, T Fraser, PE St George-Hyslop, P Tohyama, M
Citation: N. Sato et al., Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2, J BIOL CHEM, 276(3), 2001, pp. 2108-2114
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
Authors: Chishti, MA Yang, DS Janus, C Phinney, AL Horne, P Pearson, J Strome, R Zuker, N Loukides, J French, J Turner, S Lozza, G Grilli, M Kunicki, S Morissette, C Paquette, J Gervais, F Bergeron, C Fraser, PE Carlson, GA St George-Hyslop, P Westaway, D
Citation: Ma. Chishti et al., Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695, J BIOL CHEM, 276(24), 2001, pp. 21562-21570
All or none fibrillogenesis of a prion peptide
Authors: Zou, WQ Yang, DS Fraser, PE Cashman, NR Chakrabartty, A
Citation: Wq. Zou et al., All or none fibrillogenesis of a prion peptide, EUR J BIOCH, 268(18), 2001, pp. 4885-4891
Metallothionein III is reduced in Alzheimer's disease
Authors: Yu, WH Lukiw, WJ Bergeron, C Niznik, HB Fraser, PE
Citation: Wh. Yu et al., Metallothionein III is reduced in Alzheimer's disease, BRAIN RES, 894(1), 2001, pp. 37-45
Histidine residues underlie Congo red binding to A beta analogs
Authors: Inouye, H Nguyen, JT Fraser, PE Shinchuk, LM Packard, AB Kirschner, DA
Citation: H. Inouye et al., Histidine residues underlie Congo red binding to A beta analogs, AMYLOID, 7(3), 2000, pp. 179-188
Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease
Authors: Mathews, PM Cataldo, AM Kao, BH Rudnicki, AG Qin, X Yang, JL Jiang, Y Picciano, M Hulette, C Lippa, CF Bird, TD Nochlin, D Walter, J Haass, C Levesque, L Fraser, PE Andreadis, A Nixon, RA
Citation: Pm. Mathews et al., Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease, MOL MED, 6(10), 2000, pp. 878-891
Review: Modulating factors in amyloid-beta fibril formation
Authors: McLaurin, J Yang, DS Yip, CM Fraser, PE
Citation: J. Mclaurin et al., Review: Modulating factors in amyloid-beta fibril formation, J STRUCT B, 130(2-3), 2000, pp. 259-270
Presenilin structure, function and role in Alzheimer disease
Authors: Fraser, PE Yang, DS Yu, G Levesque, L Nishimura, M Arawaka, S Serpell, LC Rogaeva, E St George-Hyslop, P
Citation: Pe. Fraser et al., Presenilin structure, function and role in Alzheimer disease, BBA-MOL BAS, 1502(1), 2000, pp. 1-15
Special issue: Molecular basis of Alzheimer's disease - Preface
Authors: Fraser, PE St George-Hyslop, P
Citation: Pe. Fraser et P. St George-hyslop, Special issue: Molecular basis of Alzheimer's disease - Preface, BBA-MOL BAS, 1502(1), 2000, pp. VII-VIII
Identification of syntaxin 1A as a novel binding protein for presenilin-1
Authors: Smith, SKF Anderson, HA Yu, G Robertson, AGS Allen, SJ Tyler, SJ Naylor, RL Mason, G Wilcock, GW Roche, PA Fraser, PE Dawbarn, D
Citation: Skf. Smith et al., Identification of syntaxin 1A as a novel binding protein for presenilin-1, MOL BRAIN R, 78(1-2), 2000, pp. 100-107
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
Authors: Janus, C Pearson, J McLaurin, J Mathews, PM Jiang, Y Schmidt, SD Chishti, MA Horne, P Heslin, D French, J Mount, HTJ Nixon, RA Mercken, M Bergeron, C Fraser, PE St George-Hyslop, P Westaway, D
Citation: C. Janus et al., A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease, NATURE, 408(6815), 2000, pp. 979-982
The protofilament substructure of amyloid fibrils
Authors: Serpell, LC Sunde, M Benson, MD Tennent, GA Pepys, MB Fraser, PE
Citation: Lc. Serpell et al., The protofilament substructure of amyloid fibrils, J MOL BIOL, 300(5), 2000, pp. 1033-1039
Structural studies of soluble oligomers of the Alzheimer beta-amyloid peptide
Authors: Huang, THJ Yang, DS Plaskos, NP Go, S Yip, CM Fraser, PE Chakrabartty, A
Citation: Thj. Huang et al., Structural studies of soluble oligomers of the Alzheimer beta-amyloid peptide, J MOL BIOL, 297(1), 2000, pp. 73-87
Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells
Authors: Chen, FS Yang, DS Petanceska, S Yang, A Tandon, A Yu, G Rozmahel, R Ghiso, J Nishimura, M Zhang, DM Kawara, T Levesque, G Mills, J Levesque, L Song, YQ Rogaeva, E Westaway, D Mount, H Gandy, S St George-Hyslop, P Fraser, PE
Citation: Fs. Chen et al., Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells, J BIOL CHEM, 275(47), 2000, pp. 36794-36802
Alternate aggregation pathways of the Alzheimer beta-amyloid peptide - An in vitro model of preamyloid
Authors: Huang, THJ Yang, DS Fraser, PE Chakrabartty, A
Citation: Thj. Huang et al., Alternate aggregation pathways of the Alzheimer beta-amyloid peptide - An in vitro model of preamyloid, J BIOL CHEM, 275(46), 2000, pp. 36436-36440
alpha-synuclein membrane interactions and lipid specificity
Authors: Jo, EJ McLaurin, J Yip, CM St George-Hyslop, P Fraser, PE
Citation: Ej. Jo et al., alpha-synuclein membrane interactions and lipid specificity, J BIOL CHEM, 275(44), 2000, pp. 34328-34334
Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes
Authors: Yu, G Chen, FS Nishimura, M Steiner, H Tandon, A Kawarai, T Arawaka, S Supala, A Song, YQ Rogaeva, E Holmes, E Zhang, DM Milman, P Fraser, PE Haass, C St George-Hyslop, P
Citation: G. Yu et al., Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes, J BIOL CHEM, 275(35), 2000, pp. 27348-27353
Presenilin 1 regulates pharmacologically distinct gamma-secretase activities - Implications for the role of presenilin in gamma-secretase cleavage
Authors: Murphy, MP Uljon, SN Fraser, PE Fauq, A Lookingbill, HA Findlay, KA Smith, TE Lewis, PA McLendon, DC Wang, R Golde, TE
Citation: Mp. Murphy et al., Presenilin 1 regulates pharmacologically distinct gamma-secretase activities - Implications for the role of presenilin in gamma-secretase cleavage, J BIOL CHEM, 275(34), 2000, pp. 26277-26284
Risultati: 1-25 | 26-44