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Results: 1-15 |
Results: 15
A SMALL, NONPEPTIDYL MIMIC OF GRANULOCYTE-COLONY-STIMULATING FACTOR
Authors: TIAN SS LAMB P KING AG MILLER SG KESSLER L LUENGO JI AVERILL L JOHNSON RK GLEASON JG PELUS LM DILLON SB ROSEN J
Citation: Ss. Tian et al., A SMALL, NONPEPTIDYL MIMIC OF GRANULOCYTE-COLONY-STIMULATING FACTOR, Science, 281(5374), 1998, pp. 257-259
1,4-CYCLOHEXANECARBOXYLATES - POTENT AND SELECTIVE INHIBITORS OF PHOSPHODIESTERASE-4 FOR THE TREATMENT OF ASTHMA
Authors: CHRISTENSEN SB GUIDER A FORSTER CJ GLEASON JG BENDER PE KARPINSKI JM DEWOLF WE BARNETTE MS UNDERWOOD DC GRISWOLD DE CIESLINSKI LB BURMAN M BOCHNOWICZ S OSBORN RR MANNING CD GROUS M HILLEGAS LM BARTUS JO RYAN MD EGGLESTON DS HALTIWANGER RC TORPHY TJ
Citation: Sb. Christensen et al., 1,4-CYCLOHEXANECARBOXYLATES - POTENT AND SELECTIVE INHIBITORS OF PHOSPHODIESTERASE-4 FOR THE TREATMENT OF ASTHMA, Journal of medicinal chemistry, 41(6), 1998, pp. 821-835
DESIGN OF POTENT AND SELECTIVE HUMAN CATHEPSIN-K INHIBITORS THAT SPANTHE ACTIVE-SITE
Authors: THOMPSON SK HALBERT SM BOSSARD MJ TOMASZEK TA LEVY MA ZHAO BG SMITH WW ABDELMEGUID SS JANSON CA DALESSIO KJ MCQUENEY MS AMEGADZIE BY HANNING CR DESJARLAIS RL BRIAND J SARKAR SK HUDDLESTON MJ IJAMES CF CARR SA GARNES KT SHU A HEYS JR BRADBEER J ZEMBRYKI D LEERYKACZEWSKI L JAMES IE LARK MW DRAKE FH GOWEN M GLEASON JG VEBER DF
Citation: Sk. Thompson et al., DESIGN OF POTENT AND SELECTIVE HUMAN CATHEPSIN-K INHIBITORS THAT SPANTHE ACTIVE-SITE, Proceedings of the National Academy of Sciences of the United Statesof America, 94(26), 1997, pp. 14249-14254
STRUCTURE AND DESIGN OF POTENT AND SELECTIVE CATHEPSIN-K INHIBITORS
Authors: YAMASHITA DS SMITH WW ZHAO BG JANSON CA TOMASZEK TA BOSSARD MJ LEVY MA OH HJ CARR TJ THOMPSON SK IJAMES CF CARR SA MCQUENEY M DALESSIO KJ AMEGADZIE BY HANNING CR ABDELMEGUID S DESJARLAIS RL GLEASON JG VEBER DF
Citation: Ds. Yamashita et al., STRUCTURE AND DESIGN OF POTENT AND SELECTIVE CATHEPSIN-K INHIBITORS, Journal of the American Chemical Society, 119(46), 1997, pp. 11351-11352
SYNTHESIS AND ANTIVIRAL ACTIVITY OF A NOVEL CLASS OF HIV-1 PROTEASE INHIBITORS CONTAINING A HETEROCYCLIC P-1'-P-2' AMIDE BOND ISOSTERE
Authors: THOMPSON SK EPPLEY AM FRAZEE JS DARCY MG LUM RT TOMASZEK TA IVANOFF LA MORRIS JF STERNBERG EJ LAMBERT DM FERNANDEZ AV PETTEWAY SR MEEK TD METCALF BW GLEASON JG
Citation: Sk. Thompson et al., SYNTHESIS AND ANTIVIRAL ACTIVITY OF A NOVEL CLASS OF HIV-1 PROTEASE INHIBITORS CONTAINING A HETEROCYCLIC P-1'-P-2' AMIDE BOND ISOSTERE, Bioorganic & medicinal chemistry letters, 4(20), 1994, pp. 2441-2446
SB-209670, A RATIONALLY DESIGNED POTENT NONPEPTIDE ENDOTHELIN RECEPTOR ANTAGONIST
Authors: OHLSTEIN EH NAMBI P DOUGLAS SA EDWARDS RM GELLAI M LAGO A LEBER JD COUSINS RD GAO AM FRAZEE JS PEISHOFF CE BEAN JW EGGLESTON DS ELSHOURBAGY NA KUMAR C LEE JA YUE TL LOUDEN C BROOKS DP WEINSTOCK J FEUERSTEIN G POSTE G RUFFOLO RR GLEASON JG ELLIOTT JD
Citation: Eh. Ohlstein et al., SB-209670, A RATIONALLY DESIGNED POTENT NONPEPTIDE ENDOTHELIN RECEPTOR ANTAGONIST, Proceedings of the National Academy of Sciences of the United Statesof America, 91(17), 1994, pp. 8052-8056
TYR-129 IS IMPORTANT TO THE PEPTIDE LIGAND AFFINITY AND SELECTIVITY OF HUMAN ENDOTHELIN TYPE-A RECEPTOR
Authors: LEE JA ELLIOTT JD SUTIPHONG JA FRIESEN WJ OHLSTEIN EH STADEL JM GLEASON JG PEISHOFF CE
Citation: Ja. Lee et al., TYR-129 IS IMPORTANT TO THE PEPTIDE LIGAND AFFINITY AND SELECTIVITY OF HUMAN ENDOTHELIN TYPE-A RECEPTOR, Proceedings of the National Academy of Sciences of the United Statesof America, 91(15), 1994, pp. 7164-7168
NONPEPTIDE ENDOTHELIN RECEPTOR ANTAGONISTS .1. EFFECTS ON BINDING ANDSIGNAL-TRANSDUCTION ON HUMAN ENDOTHELIN(A) AND ENDOTHELIN(B) RECEPTORS
Authors: NAMBI P ELSHOURBAGY N WU HL PULLEN M OHLSTEIN EH BROOKS DP LAGO MA ELLIOTT JD GLEASON JG RUFFOLO RR
Citation: P. Nambi et al., NONPEPTIDE ENDOTHELIN RECEPTOR ANTAGONISTS .1. EFFECTS ON BINDING ANDSIGNAL-TRANSDUCTION ON HUMAN ENDOTHELIN(A) AND ENDOTHELIN(B) RECEPTORS, The Journal of pharmacology and experimental therapeutics, 271(2), 1994, pp. 755-761
NONPEPTIDE ENDOTHELIN RECEPTOR ANTAGONISTS .2. PHARMACOLOGICAL CHARACTERIZATION OF SB-209670
Authors: OHLSTEIN EH BECK GR DOUGLAS SA NAMBI P LAGO MA GLEASON JG RUFFOLO RR FEUERSTEIN G ELLIOTT JD
Citation: Eh. Ohlstein et al., NONPEPTIDE ENDOTHELIN RECEPTOR ANTAGONISTS .2. PHARMACOLOGICAL CHARACTERIZATION OF SB-209670, The Journal of pharmacology and experimental therapeutics, 271(2), 1994, pp. 762-768
NONPEPTIDE ENDOTHELIN RECEPTOR ANTAGONISTS .3. EFFECT OF SB-209670 AND BQ123 ON ACUTE-RENAL-FAILURE IN ANESTHETIZED DOGS
Authors: BROOKS DP DEPALMA PD GELLAI M NAMBI P OHLSTEIN EH ELLIOTT JD GLEASON JG RUFFOLO RR
Citation: Dp. Brooks et al., NONPEPTIDE ENDOTHELIN RECEPTOR ANTAGONISTS .3. EFFECT OF SB-209670 AND BQ123 ON ACUTE-RENAL-FAILURE IN ANESTHETIZED DOGS, The Journal of pharmacology and experimental therapeutics, 271(2), 1994, pp. 769-775
RATIONAL DESIGN, SYNTHESIS, AND CRYSTALLOGRAPHIC ANALYSIS OF A HYDROXYETHYLENE-BASED HIV-1 PROTEASE INHIBITOR CONTAINING A HETEROCYCLIC P-1' P-2' AMIDE BOND ISOSTERE
Authors: THOMPSON SK MURTHY KHM ZHAO B WINBORNE E GREEN DW FISHER SM DESJARLAIS RL TOMASZEK TA MEEK TD GLEASON JG ABDELMEGUID SS
Citation: Sk. Thompson et al., RATIONAL DESIGN, SYNTHESIS, AND CRYSTALLOGRAPHIC ANALYSIS OF A HYDROXYETHYLENE-BASED HIV-1 PROTEASE INHIBITOR CONTAINING A HETEROCYCLIC P-1' P-2' AMIDE BOND ISOSTERE, Journal of medicinal chemistry, 37(19), 1994, pp. 3100-3107
1,3-DIARYLINDAN-2-CARBOXYLIC ACIDS, POTENT AND SELECTIVE NONPEPTIDE ENDOTHELIN RECEPTOR ANTAGONISTS
Authors: ELLIOTT JD LAGO MA COUSINS RD GAO AM LEBER JD ERHARD KF NAMBI P ELSHOURBAGY NA KUMAR C LEE JA BEAN JW DEBROSSE CW EGGLESTON DS BROOKS DP FEUERSTEIN G RUFFOLO RR WEINSTOCK J GLEASON JG PEISHOFF CE OHLSTEIN EH
Citation: Jd. Elliott et al., 1,3-DIARYLINDAN-2-CARBOXYLIC ACIDS, POTENT AND SELECTIVE NONPEPTIDE ENDOTHELIN RECEPTOR ANTAGONISTS, Journal of medicinal chemistry, 37(11), 1994, pp. 1553-1557
LYSINE-182 OF ENDOTHELIN-B RECEPTOR MODULATES AGONIST SELECTIVITY ANDANTAGONIST AFFINITY - EVIDENCE FOR THE OVER-LAP OF PEPTIDE AND NONPEPTIDE LIGAND-BINDING SITES
Authors: LEE JA BRINKMANN JA LONGTON ED PEISHOFF CE LAGO MA LEBER JD COUSINS RD GAO AM STADEL JM KUMAR CS OHLSTEIN EH GLEASON JG ELLIOTT JD
Citation: Ja. Lee et al., LYSINE-182 OF ENDOTHELIN-B RECEPTOR MODULATES AGONIST SELECTIVITY ANDANTAGONIST AFFINITY - EVIDENCE FOR THE OVER-LAP OF PEPTIDE AND NONPEPTIDE LIGAND-BINDING SITES, Biochemistry, 33(48), 1994, pp. 14543-14549
SYNTHESIS AND LTB(4) RECEPTOR ANTAGONIST ACTIVITIES OF THE NATURALLY-OCCURRING LTB(4) RECEPTOR ANTAGONIST LEUCETTAMINE-A AND RELATED ANALOGS
Authors: BOEHM JC GLEASON JG PENDRAK I SARAU HM SCHMIDT DB FOLEY JJ KINGSBURY WD
Citation: Jc. Boehm et al., SYNTHESIS AND LTB(4) RECEPTOR ANTAGONIST ACTIVITIES OF THE NATURALLY-OCCURRING LTB(4) RECEPTOR ANTAGONIST LEUCETTAMINE-A AND RELATED ANALOGS, Journal of medicinal chemistry, 36(22), 1993, pp. 3333-3340
DIRECT DESIGN OF A POTENT NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONIST BASED ON THE STRUCTURE AND CONFORMATION OF A HIGHLY CONSTRAINED CYCLIC RGD PEPTIDE
Authors: KU TW ALI FE BARTON LS BEAN JW BONDINELL WE BURGESS JL CALLAHAN JF CALVO RR CHEN LC EGGLESTON DS GLEASON JG HUFFMAN WF HWANG SM JAKAS DR KARASH CB KEENAN RM KOPPLE KD MILLER WH NEWLANDER KA NICHOLS A PARKER MF PEISHOFF CE SAMANEN JM UZINSKAS I VENSLAVSKY JW
Citation: Tw. Ku et al., DIRECT DESIGN OF A POTENT NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONIST BASED ON THE STRUCTURE AND CONFORMATION OF A HIGHLY CONSTRAINED CYCLIC RGD PEPTIDE, Journal of the American Chemical Society, 115(19), 1993, pp. 8861-8862
Risultati: 1-15 |