AAAAAA

   
Results: 1-25 | 26-29
Results: 1-25/29
DNA binding cationic bolasomes with delocalized charge center - A structure-activity relationship study
Authors: Weissig, V Lizano, C Ganellin, CR Torchilin, VP
Citation: V. Weissig et al., DNA binding cationic bolasomes with delocalized charge center - A structure-activity relationship study, STP PHARM S, 11(1), 2001, pp. 91-96
Different antagonist binding properties of human and rat histamine H-3 receptors
Authors: Stark, H Sippl, W Ligneau, X Arrang, JM Ganellin, CR Schwartz, JC Schunack, W
Citation: H. Stark et al., Different antagonist binding properties of human and rat histamine H-3 receptors, BIOORG MED, 11(7), 2001, pp. 951-954
Influence of imidazole replacement in different structural classes of histamine H-3-receptor antagonists
Authors: Meier, G Apelt, J Reichert, U Grassmann, S Ligneau, X Elz, S Leurquin, F Ganellin, CR Schwartz, JC Schunack, W Stark, H
Citation: G. Meier et al., Influence of imidazole replacement in different structural classes of histamine H-3-receptor antagonists, EUR J PH SC, 13(3), 2001, pp. 249-259
Medicinal chemistry in the development of societies. Biodiversity and natural products
Authors: Monge, A Chorghade, M Erhardt, PW Ganellin, CR Koga, N Lindberg, P Perun, TJ Topliss, JG Trivedi, BK Wermunth, CG
Citation: A. Monge et al., Medicinal chemistry in the development of societies. Biodiversity and natural products, BOL SOC CH, 46(2), 2001, pp. 143-148
Benzophenone derivatives and related compounds as potent histamine H-3-receptor antagonists and potential PET/SPECT ligands
Authors: Sasse, A Ligneau, X Sadek, B Elz, S Pertz, HH Ganellin, CR Arrang, JM Schwartz, JC Schunack, W Stark, H
Citation: A. Sasse et al., Benzophenone derivatives and related compounds as potent histamine H-3-receptor antagonists and potential PET/SPECT ligands, ARCH PHARM, 334(2), 2001, pp. 45-52
Synthesis and structure-activity relationships of cetiedil analogues as blockers of the Ca2+-activated K+ permeability of erythrocytes
Authors: Roxburgh, CJ Ganellin, CR Athmani, S Bisi, A Quaglia, W Benton, DCH Shiner, MAR Malik-Hall, M Haylett, DG Jenkinson, DH
Citation: Cj. Roxburgh et al., Synthesis and structure-activity relationships of cetiedil analogues as blockers of the Ca2+-activated K+ permeability of erythrocytes, J MED CHEM, 44(20), 2001, pp. 3244-3253
Calcium-activated potassium channels sustain calcium signaling in T lymphocytes - Selective blockers and manipulated channel expression levels
Authors: Fanger, CM Rauer, H Neben, AL Miller, MJ Rauer, H Wulff, H Rosa, JC Ganellin, CR Chandy, KG Cahalan, MD
Citation: Cm. Fanger et al., Calcium-activated potassium channels sustain calcium signaling in T lymphocytes - Selective blockers and manipulated channel expression levels, J BIOL CHEM, 276(15), 2001, pp. 12249-12256
Clotrimazole analogues: effective blockers of the slow afterhyperpolarization in cultured rat hippocampal pyramidal neurones
Authors: Shah, MM Miscony, Z Javadzadeh-Tabatabaie, M Ganellin, CR Haylett, DG
Citation: Mm. Shah et al., Clotrimazole analogues: effective blockers of the slow afterhyperpolarization in cultured rat hippocampal pyramidal neurones, BR J PHARM, 132(4), 2001, pp. 889-898
Anesthetic-like interaction of the sleep-inducing lipid oleamide with voltage-gated sodium channels in mammalian brain
Authors: Nicholson, RA Zheng, J Ganellin, CR Verdon, B Lees, G
Citation: Ra. Nicholson et al., Anesthetic-like interaction of the sleep-inducing lipid oleamide with voltage-gated sodium channels in mammalian brain, ANESTHESIOL, 94(1), 2001, pp. 120-128
(Partial) agonist/antagonist properties of novel diarylalkyl carbamates onhistamine H-3 receptors
Authors: Sasse, A Stark, H Ligneau, X Elz, S Reidemeister, S Ganellin, CR Schwartz, JC Schunack, W
Citation: A. Sasse et al., (Partial) agonist/antagonist properties of novel diarylalkyl carbamates onhistamine H-3 receptors, BIO MED CH, 8(5), 2000, pp. 1139-1149
Analogues and derivatives of ciproxifan, a novel prototype for generating potent histamine H-3-receptor antagonists
Authors: Stark, H Ligneau, X Sadek, B Ganellin, CR Arrang, JM Schwartz, JC Schunack, W
Citation: H. Stark et al., Analogues and derivatives of ciproxifan, a novel prototype for generating potent histamine H-3-receptor antagonists, BIOORG MED, 10(20), 2000, pp. 2379-2382
Medicinal chemistry in the development of societies - Biodiversity and natural products
Authors: Monge, A Chorghade, M Erhardt, PW Ganellin, CR Koga, N Lindberg, P Perun, TJ Topliss, JG Trivedi, BK Wermuth, CG
Citation: A. Monge et al., Medicinal chemistry in the development of societies - Biodiversity and natural products, EUR J MED C, 35(12), 2000, pp. 1121-1125
University education of medicinal chemists: comparison of eight countries
Authors: Ganellin, CR Mitscher, LA Clement, B Kobayashi, TH Kyburz, E Lafont, O Marcinal, A Monge, A Tarzia, G Topliss, JG
Citation: Cr. Ganellin et al., University education of medicinal chemists: comparison of eight countries, EUR J MED C, 35(1), 2000, pp. 163-174
Importance of the lipophilic group in carbamates having histamine H-3-receptor antagonist activity
Authors: Kiec-Kononowicz, K Wiecek, M Sasse, A Ligneau, X Elz, S Ganellin, CR Schwartz, JC Stark, H Schunack, W
Citation: K. Kiec-kononowicz et al., Importance of the lipophilic group in carbamates having histamine H-3-receptor antagonist activity, PHARMAZIE, 55(5), 2000, pp. 349-355
Substituted N-phenylcarbamates as histamine H-3 receptor antagonists with improved in vivo potency
Authors: Reidemeister, S Stark, H Ligneau, X Ganellin, CR Schwartz, JC Schunack, W
Citation: S. Reidemeister et al., Substituted N-phenylcarbamates as histamine H-3 receptor antagonists with improved in vivo potency, PHARMAZIE, 55(2), 2000, pp. 83-86
High constitutive activity of native H-3 receptors regulates histamine neurons in brain
Authors: Morisset, S Rouleau, A Ligneau, X Gbahou, F Tardivel-Lacombe, J Stark, H Schunack, W Ganellin, CR Schwartz, JC Arrang, JM
Citation: S. Morisset et al., High constitutive activity of native H-3 receptors regulates histamine neurons in brain, NATURE, 408(6814), 2000, pp. 860-864
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: A strategy for the design of peptidase inhibitors
Authors: Ganellin, CR Bishop, PB Bambal, RB Chan, SMT Law, JK Marabout, B Luthra, PM Moore, ANJ Peschard, O Bourgeat, P Rose, C Vargas, F Schwartz, JC
Citation: Cr. Ganellin et al., Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: A strategy for the design of peptidase inhibitors, J MED CHEM, 43(4), 2000, pp. 664-674
Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: Potent, non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel
Authors: Rosa, JC Galanakis, D Piergentili, A Bhandari, K Ganellin, CR Dunn, PM Jenkinson, DH
Citation: Jc. Rosa et al., Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: Potent, non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel, J MED CHEM, 43(3), 2000, pp. 420-431
Novel histamine H-3-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds
Authors: Stark, H Sadek, B Krause, M Huls, A Ligneau, X Ganellin, CR Arrang, JM Schwartz, JC Schunack, W
Citation: H. Stark et al., Novel histamine H-3-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds, J MED CHEM, 43(21), 2000, pp. 3987-3994
Bis-quinolinium cyclophanes: 8,14-diaza-1,7(1,4)-diquinolinacyclo-tetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apamin-sensitive Ca2+-activated K+ channel
Authors: Chen, JQ Galanakis, D Ganellin, CR Dunn, PM Jenkinson, DH
Citation: Jq. Chen et al., Bis-quinolinium cyclophanes: 8,14-diaza-1,7(1,4)-diquinolinacyclo-tetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apamin-sensitive Ca2+-activated K+ channel, J MED CHEM, 43(19), 2000, pp. 3478-3481
New histamine H-3-receptor ligands of the proxifan series: Imoproxifan andother selective antagonists with high oral in vivo potency
Authors: Sasse, A Sadek, B Ligneau, X Elz, S Pertz, HH Luger, P Ganellin, CR Arrang, JM Schwartz, JC Schunack, W Stark, H
Citation: A. Sasse et al., New histamine H-3-receptor ligands of the proxifan series: Imoproxifan andother selective antagonists with high oral in vivo potency, J MED CHEM, 43(17), 2000, pp. 3335-3343
Distinct pharmacology of rat and human histamine H-3 receptors: role of two amino acids in the third transmembrane domain
Authors: Ligneau, X Morisset, S Tardivel-Lacombe, J Gbahou, F Ganellin, CR Stark, H Schunack, W Schwartz, JC Arrang, JM
Citation: X. Ligneau et al., Distinct pharmacology of rat and human histamine H-3 receptors: role of two amino acids in the third transmembrane domain, BR J PHARM, 131(7), 2000, pp. 1247-1250
Compounds that block both intermediate-conductance (IKCa) and small-conductance (SKCa) calcium-activated potassium channels
Authors: Malik-Hall, M Ganellin, CR Galanakis, D Jenkinson, DH
Citation: M. Malik-hall et al., Compounds that block both intermediate-conductance (IKCa) and small-conductance (SKCa) calcium-activated potassium channels, BR J PHARM, 129(7), 2000, pp. 1431-1438
Stereoselective modulatory actions of oleamide on GABA(A) receptors and voltage-gated Na+ channels in vitro: a putative endogenous ligand for depressant drug sites in CNS
Authors: Verdon, B Zheng, J Nicholson, RA Ganellin, CR Lees, G
Citation: B. Verdon et al., Stereoselective modulatory actions of oleamide on GABA(A) receptors and voltage-gated Na+ channels in vitro: a putative endogenous ligand for depressant drug sites in CNS, BR J PHARM, 129(2), 2000, pp. 283-290
Development of chiral N-alkylcarbamates as new leads for potent and selective H-3-receptor antagonists: Synthesis, capillary electrophoresis, and in vitro and oral in vivo activity
Authors: Sasse, A Kiec-Kononowicz, K Stark, H Motyl, M Reidemeister, S Ganellin, CR Ligneau, X Schwartz, JC Schunack, W
Citation: A. Sasse et al., Development of chiral N-alkylcarbamates as new leads for potent and selective H-3-receptor antagonists: Synthesis, capillary electrophoresis, and in vitro and oral in vivo activity, J MED CHEM, 42(4), 1999, pp. 593-600
Risultati: 1-25 | 26-29